Wu, Chung-Yi


[ CV ]




  • Ph D., Applied Chemistry, National Chiao-Tung University, Hsinchu, Taiwan, 2000
  • Postdoctoral Fellow, Academia Sinica, Taiwan, 2000-2006
  • Postdoctoral Fellow, The Scripps Research Institute, USA, 2004-2006
  • Assistant Professor, Genomics Research Center, Academia Sinica, 2006-2011
  • Associate Professor, Genomics Research Center, Academia Sinica, 2011-2016
  • Professor, Genomics Research Center, Academia Sinica, 2016-present


  • Spring Prize of NCTU bronze medal, 1994
  • Postdoctoral Fellowship of Academia Sinica, 2000-2004
  • Cooperative Post-doctoral Research Visit Program of National Science Council, The Scripps Research Institute (USA), 2004-2006
  • Project for Excellent Junior Research Investigators Award, National Science Council, Taiwan, 2012
  • Career Development Award, Academia Sinica, Taiwan, 2012
  • Academia Sinica Research Award for Junior Research Investigators, 2012
  • The David Y. Gin New Investigator Award, American Chemical Society, 2014


Synthesis of oligosaccharide and development of sugar array.

More than 50% of human proteins are glycosylated. Glycomics has emerged with proteomics as an area for development and exploration in the postgenomic era. In comparison with genomics and proteomics, there are two major problems to defer the development of this field. The first is non automated synthesis of oligosaccharides platform exit. Second is needed to develop a more rapid method in glycoprotein sequencing, developing analytical and biochemical tools and biological readouts to investigate glycan structure-function relationships.
We focus on the development of novel and efficient methodologies to prepare biologically potent oligosaccharides and design the new type sugar array to address the bio-function of oligosaccharides.

Sugar array_and_its_applications Carbohydrate-based vaccines_design Ultrasensitive naked_eye_detection
      Glycan Array and Its Applications      Carbohydrate-based vaccines design        Ultrasensitive naked eye detection


  • Lee Chang-Chun D., Watanabe Yasunori, Wu Nicholas C., Han Julianna, Kumar Sonu, Pholcharee Tossapol, Seabright Gemma E., Allen Joel D., Lin Chih-Wei, Yang Ji-Rong, Liu Ming-Tsan, Wu Chung-Yi, Ward Andrew B., Crispin Max, Wilson Ian A., 2021, “A cross-neutralizing antibody between HIV-1 and influenza virus”, PLOS Pathogens, 17(3), e1009407. (SCIE)
  • Chuang Hong-Yang, Huang Chiu-Chen, Hung Ting-Chun, Huang Lin-Ya, Chiu Chih-Wei, Chu Kuo-Ching, Liao Jung-Yu, You Tsai-Hong, Wu Chung-Yi, Chao Ping, Shivatare Sachin S., Zeng Yi-Fang, Tsai Charng-Sheng, Lin Nan-Horng, Wu Chung-Yi*, 2021, “Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies”, Bioorganic Chemistry, 112, 104863. (SCIE)
  • Chein-Hung Chen, Ya-Ping Lin, Chien-Tai Ren, Sachin S Shivatare , Nan-Hon Lin, Chung-Yi Wu , Chung-Hsuan Chen, Jung-Lee Lin*, 2020, “Enhancement of fucosylated N-glycan isomer separation with an ultrahigh column temperature in porous graphitic carbon liquid chromatography-mass spectrometry”, JOURNAL OF CHROMATOGRAPHY A, 1632, 461610. (SCIE)
  • Mettu Ravinder, Kuo-Shiang Liao, Yang-Yu Cheng, Sujeet Pawar, Tzu-Lung Lin, Jin-Town Wang, and Chung-Yi Wu*, 2020, “A Synthetic Carbohydrate–Protein Conjugate Vaccine Candidate against Klebsiella pneumoniae Serotype K2”, JOURNAL OF ORGANIC CHEMISTRY, 85(24), 15964-15997. (SCIE)
  • Cheng-Wei Cheng , Chung-Yi Wu, Wen-Lian Hsu , Chi-Huey Wong*, 2020, “Programmable One-Pot Synthesis of Oligosaccharides”, BIOCHEMISTRY, 59(34),3078-3088. (SCIE)
  • Yo-Min Liu, Md. Shahed-Al-Mahmud, Xiaorui Chen, Ting-Hua Chen, Kuo-Shiang Liao, Jennifer M. Lo, Yi-Min Wu, Meng-Chiao Ho, Chung-Yi Wu, Chi-Huey Wong, Jia-Tsrong Jan, and Che Ma*, 2020, “A carbohydrate-binding protein from the edible Lablab beans effectively blocks the infections of influenza viruses and SARS-CoV-2”, CELL REPORTS, 32(6), 118016. (SCIE)
  • Sujeet Pawar, Li Hsu, Thatikonda Narendar Reddy, Mettu Ravinder, Chien-Tai Ren, Yu-Wei Lin, Yang-Yu Cheng, Tzu-Wen Lin, Tsui-Ling Hsu, Sheng-Kai Wang, Chi-Huey Wong*, and Chung-Yi Wu*, 2020, “Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation”, ACS CHEMICAL BIOLOGY, 15(9), 2382-2394. (SCIE)
  • Ravinder Mettu, Chiang-Yun Chen and Chung-Yi Wu*, 2020, “Synthetic carbohydrate-based vaccines: challenges and opportunities”, JOURNAL OF BIOMEDICAL SCIENCE, 27, 1. (SCIE)
  • Yu-Hsuan Lih, Sachin S. Shivatare and Chung-Yi Wu*, 2019, Synthetic Glycomes, in press pages, Cambridge: Royal Society of Chemistry.
  • H.-J. Lo, L. Krasnova, S. Dey, T. Cheng, H. Liu, T.-I. Tsai, K. B. Wu, C.-Y. Wu, and C.-H. Wong*, 2019, “Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing alpha2,6-Linked 3F(ax)-Neu5Ac”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(16), 6484-6488. (SCIE)
  • TSAI‑KUN WU, CHYOU‑WEI WEI, YING‑RU PAN, Ren-Jun Hsu, Chung-Yi Wu, and Yung-Luen Yu*, 2019, “The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal cell carcinoma via microRNA-21/ HIF-1α axis signals”, SCIENTIFIC REPORTS, 9,3207. (SCIE)
  • Chuang Po-Kai, Hsiao Michael, Hsu Tsui-Ling, Chang Chuan-Fa, Wu Chung-Yi, Chen Bo-Rui, Huang Han-Wen, Liao Kuo-Shiang, Chen Chen-Chun, Chen Chi-Long, Yang Shun-Min, Kuo Chiung Wen, Chen Peilin, Chiu Ping-Tzu, Chen I-Ju, Lai Jiann-Shiun, Yu Cheng-Der Tony, Wong Chi-Huey*, 2019, “Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer”, Proceedings of the National Academy of Sciences of the United States of America, 116(9), 3518-3523. (SCIE)
  • Cheng Cheng-Wei, Zhou Yixuan, Pan Wen-Harn, Dey Supriya, (Wu Chung-Yi, Hsu Wen-Lian*, Wong Chi-Huey*, 2018, “Hierarchical and programmable one-pot synthesis of oligosaccharides”, Nature Communications, 9(1), 5202. (SCIE)
  • Lo Pei-Wen, Shie Jiun-Jie, Chen Chein-Hung, Wu Chung-Yi, Hsu Tsui-Ling, Wong Chi-Huey, 2018, “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(28), 7302-7307. (SCIE)
  • Lee I-Ming, Yang Feng-Ling, Chen Te-Li, Liao Kuo-Shiang, Ren Chien-Tai, Lin Nien-Tsung, Chang Yu-Pei, Wu Chung-Yi*, Wu Shih-Hsiung*, 2018, “Pseudaminic acid on exopolysaccharide of Acinetobacter baumannii plays a critical role in phage-assisted preparation of glycoconjugate vaccine with high antigenicity.”, Journal of the American Chemical Society, 140(28), 8639-8643. (SCIE)
  • Shivatare Sachin S., Huang Lin-Ya, Zeng Yi-Fang, Liao Jung-Yu, You Tsai-Hong, Wang Shi-Yun, Cheng Ting, Chiu Chih-Wei, Chao Ping, Chen Li-Tzu, Tsai Tsung-I, Huang Chiu-Chen, Wu Chung-Yi*, Lin Nan-Horng*, Wong Chi-Huey*, 2018, “Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies”, Chemical Communications, 54(48), 6161-6164. (SCIE)
  • Shivatare Vidya S., Shivatare Sachin S., Lee Chang-Chun David, Liang Chi-Hui, Liao Kuo-Shiang, Cheng Yang-Yu, Saidachary Gannerla, Wu Chung-Yi, Lin Nan-Horng, Kwong Peter D., Burton Dennis R., Wu Chung-Yi*, Wong Chi-Huey*, 2018, “Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies”, Journal of the American Chemical Society, 140(15), 5202-5210. (SCIE)
  • Zhou Jie, Wei Jianjian, Choy Ka-Tim, Sia Sin Fun, Rowlands Dewi K., Yu Dan, Wu Chung-Yi, Lindsley William G., Cowling Benjamin J., McDevitt James, Peiris Malik, Li Yuguo, Yen Hui-Ling, 2018, “Defining the sizes of airborne particles that mediate influenza transmission in ferrets”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(10), E2386-E2392. (SCIE)
  • Tongqing Zhou, Anqi Zheng, Ulrich Baxa, Gwo-Yu Chuang, Ivelin S. Georgiev, Rui Kong, Sijy O'Dell, Syed Shahzad-ul-Hussan, Chen-Hsiang Shen, Yaroslav Tsybovsky, Robert T. Bailer, Syna K. Gift, Mark K. Louder, Krisha McKee, Reda Rawi, Catherine H. Stevenson, Guillaume B. E. Stewart-Jones, Justin D. Taft, Eric Waltari, Yongping Yang, Baoshan Zhang, Sachin S. Shivatare, Vidya S. Shivatare, Chang-Chun D. Lee, Chung-Yi Wu, NISC Comparative Sequencing Program, James C. Mullikin, Carole A. Bewley, Dennis R. Burton, Victoria R. Polonis, Lawrence Shapiro, Chi-Huey Wong, John R. Mascola,* Peter D. Kwong* and Xueling Wu*, 2018, “Structural Basis of Recognition by an Antibody Targeting the Silent Face of HIV Envelope”, IMMUNITY, 48(3), 500-513. (SCIE)
  • Shivatare Sachin S., Shivatare Vidya S., Wu Chung-Yi, Wong Chi-Huey*, 2018, “Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling”, Jove-Journal of Visualized Experiments, 132, e55855. (SCIE)
  • Chiu-Ping Liu, Tsung-I Tsai, Ting Cheng, Vidya S. Shivatare, Chung-Yi Wu, Chung-Yi Wu, and Chi-Huey Wong*, 2018, “Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(4), 720-725. (SCIE)
  • Kim Hyeon-Ji, Wu Chung-Yi, Yu Hui-Ming, Sheen Jen, Lee Horim*, 2017, “Dual CLAVATA3 peptides in Arabidopsis shoot stem cell signaling”, Journal of Plant Biology, 60(5), 506-512. (SCIE)
  • Andrabi Raiees, Su Ching-Yao, Liang Chi-Hui, Shivatare Sachin S., Briney Bryan, Voss James E., Nawazi Salar Khan, Wu Chung-Yi, Wong Chi-Huey, Burton Dennis R.*, 2017, “Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development”, Immunity, 47(3), 524-537.e3. (SCIE)
  • Chen Chia-Lin, Hsu Jen-Chi, Lin Chin-Wei, Wang Chia-Hung, Tsai Ming-Hung, Wu Chung-Yi, Wong Chi-Huey*, Ma Che*, 2017, “Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity”, ACS Chemical Biology, 12(5), 1335-1345. (SCIE)
  • Yang W., Punyadarsaniya D., Lambertz R. L. O., Lee D. C. C., Liang C. H., Höper D., Leist S. R., Hernández-Cáceres A., Stech J., Beer M., Wu C. Y., Wong C. H., Schughart K., Meng F., Herrler G., 2017, “Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice”, Journal of Virology, 91(8), e02125-16. (SCIE)
  • I-Ming Lee, I-Fan Tu, Feng-Ling Yang, Tzu-Ping Ko, Jiahn-Haur Liao, Nien-Tsung Lin, Chung-Yi Wu, Chien-Tai Ren, Andrew HJ Wang, Ching-Ming Chang, Kai-Fa Huang*, Shi-Hsiung Wu*., 2017, “Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumanni by bacteriophage Phi AB6 tailspike protein.”, SCIENTIFIC REPORTS, 7, 42711. (SCIE)
  • Tsung-I Tsai, Shiou-Ting Li, Chiu-Ping Liu, Karen Y Chen, Sachin S. Shivatare, Chin-Wei Lin, Tsui-Ling Hsu, Ying-Ta Wu, Ming-Hung Tsai, Meng-Yu Lai, Nan-Horng Lin, Chung-Yi Wu, Chi-Huey Wong*., 2017, “An Effective Bacterial Fucosidase for Glycoprotein Remodeling.”, ACS CHEMICAL BIOLOGY, 12, 63-72. (SCIE)
  • Ting Cheng-Yueh, Lin Yu-Wei, Wu Chung-Yi, Wong Chi-Huey*, 2017, “Design of Disaccharide Modules for a Programmable One-Pot Synthesis of Building Blocks with LacNAc Repeating Units for Asymmetric N-Glycans”, Asian Journal of Organic Chemistry, 6(12), 1800-1807. (SCIE)
  • Susan Yu Tseng, Wen-Hao Cho, James Su, Shih-Huang Chang, Donyau Chiang, Chung-Yi Wu, Chien-Nan Hsiao, Chi-Huey Wong*, 2016, “Preparation of Aluminum Oxide-Coated Glass Slides for Glycan Microarrays.”, ACS Omega, 1, 773-783. (SCIE)
  • Devin Sok, Mattias Pauthner, Bryan Briney, jeong Hyun Lee, Karen J Save-Francisco, Jessica Hsueh, Alejandra Ramos, Khoa M Le, Meaghan Jones, Joseph G Jardine, Raiza Bastidas, Anita Sarkar, Chi-Hui Liang, Sachin S Shivatare, Chung-Yi Wu, William R Schief, Chi-Huey Wong, Ian A Wilson, Andrew B Ward, Jiang Zhu, Pascal Poignard, Dennis R Burton*, 2016, “A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans.”, IMMUNITY, 45, 31-45. (SCIE)
  • Daniel T Macleod, Nancy M Choi, Bryan Briney, Fernando Garces, Lorena S, Ver, Elise Landais, Ben Murrell, Terri Wrin, William Kilembe, Chi-Hui Liang Alejandra Ramos, Chaoran B Bian, Lalinda Wickramasinghe, Leopold Kong, Kemal Eren, Chung-Yi Wu, Chi-Huey Wong, Sergei L Kosakovsky Pond, Ian A Wilson, Bennis R Burton, Pascal Poignard*., 2016, “Early antibody lineage diversification and independent limb maturation lead to broad HIV-1 neutralization targeting the Env high-mannose patch.”, IMMUNITY, 44, 1215-1226. (SCIE)
  • Jiahn-Haur Liao, Chih-Ta Henry Chien, Han-Ying Wu, Kai-Fa Huang, Iren Wang, Meng-Ru Ho, I-Fan Tu, I-Ming Lee, Wei Li, Yu-Ling Shih, Chung-Yi Wu, Pavel A. Lukyanov, Shang-TeDanny Hsu, Shih-Hsiung Wu , 2016, “A multivalent marine lectin from Crenomytilus grayanus possesses anti-cancer activity through recognizing globotriose Gb3.”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138(14), 4787-4795. (SCIE)
  • Sachin S Shivatare, Shih-Huang Chang, Tsung-I Tsai, Susan Yu Tseng, Yih-Shyan Lin,Yang-Yu Cheng, Chien-Tai Ren, Chang-Chun David Lee, Sujeet Pawar, Charng-Sheng Tsai,Hao-Wei Shih, Yi-Fang Zeng, Chi-Hui Liang Peter D. Kwong, Dennis R. Burton, Chung-Yi Wu,* Chi-Huey Wong*, 2016, “Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies”, Nature Chemistry, 8(4), 338-346. (SCIE)
  • Guillaume B. E. Stewart-Jones, Cinque Soto, Thomas Lemmin, Gwo-Yu Chuang, Aliaksandr Druz, Rui Kong, Paul V. Thomas, Kshitij Wagh, Tongqing Zhou, Anna-Janina Behrens, Tatsiana Bylund, Chang W. Choi, Jack R. Davison, Ivelin S. Georgiev, M. Gordon Joyce, Young Do Kwon, Marie Pancera, Justin Taft, Yongping Yang, Baoshan Zhang, Sachin S. Shivatare, Vidya S. Shivatare, Chang-Chun D. Lee, Chung-Yi Wu, Carole A. Bewley, Dennis R. Burton,, Wayne C. Koff, Mark Connors, Max Crispin, Ulrich Baxa, Bette T. Korber, Chi-Huey Wong, John R. Mascola and Peter D. Kwong*, 2016, “Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.”, CELL, 165(4), 813-826. (SCIE)
  • Primadona Indah, Lai Yin-Hung, Capangpangan Rey Y., Obena Rofeamor P., Tseng Mei-Chun, Huang Ming-Feng, Chang Huan-Tsung, Li Shiou-Ting, Wu Chung-Yi, Chien Wei-Ting, Lin Chun-Cheng, Wang Yi-Sheng, Chen Yu-Ju, 2016, “Functionalized HgTe nanoparticles promote laser-induced solid phase ionization/dissociation for comprehensive glycan sequencing”, The Analyst, 141(21), 6093-6103. (SCIE)
  • Andrabi, R., Voss, J. E., Liang, C.-H., Briney, B., McCoy, L. E., Wu, C.-Y., Wong, C.-H., Poignard, P., Burton, D. R., 2015, “Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design”, IMMUNITY, 43, 959-973. (SCIE)
  • CW Lin, MH Tsai, ST Li, TI Tsai, KC Chu, YC Liu, MY Lai, YC Tseng, CY Wu, SS Shivatare, CH Wang, P Chao, SY Wang, HW Shih, YF Zeng, TH You, JY Liao, CL Chen, CS Tsai, CC Huang, NH Lin, C Ma, CY Wu*, CH Wong*, 2015, “A common glycan structure on immunoglobulin G for enhancement of effector functions.”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(34), 10611-10616. (SCIE)
  • Huang YL, Pai FS, Tsou YT, Mon HC, Hsu TL, Wu CY, Chou TY, Yang WB, Chen CH, Wong CH, Hsieh SL*, 2015, “Human CLEC18 gene cluster contains C-type lectins with differential glycan-binding specificity.”, The Journal of biological chemistry, 290(35), 21252-21263. (SCIE)
  • Liang, C.-H.; Hsu, C.-H.; Wu, C.-Y.*, 2015, “Sialoside Arrays: New Synthetic Strategies and Applications”, Topics in Current Chemistry, 367, 125-149. (SCIE)
  • Lee, H.-Y., Chen, C.-Y., Tsai, T.-I., Li, S.-T., Lin, K.-H., Cheng, Y.-Y., Ren, C.-T., Cheng, T.-J., Wu, C.-Y.*, Wong, C.-H.* , 2014, “Immunogenicity study of Globo H derivatives with modification at the reducing or non-reducing end of the tumor antigen”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 16844-16853. (SCIE)
  • Wu, C.-S., Lee, T.-Y., Chou, R.-H., Yen, C.-J., Huang, W.-C., Wu, C.-Y., Yu, Y.-L., 2014, “Development of a Highly Sensitive Glycan Microarray for Quantifying AFP-L3 for Early Prediction of Hepatitis B Virus-Related Hepatocellular Carcinoma.”, PLoS One, 9, e99959. (SCIE)
  • Wang, C.-Y., Wu, C.-Y., Hung, T.-J., Wong, C.-H., Chen, C.-H.* , 2014, “Sequence-Constructive SELEX: A New Strategy for Screening DNA Aptamer Binding to Globo H”, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 452, 484-489. (SCIE)
  • Chen-Shiou Wu, Chia-Jui Yen, Ruey-Hwang Chou, Chung-Yi Wu*, Yung-Luen Yu*, 2014, “Downregulation of MicroRNA-15b by Hepatitis B Virus X Enhances Hepatocellular Carcinoma Proliferation via Fucosyltransferase 2-Induced Globo H Expression”, INTERNATIONAL JOURNAL OF CANCER, 134(7), 1638-1647. (SCIE)
  • Y.-S. Chen, H.-M. Yu, J.-J. Shie, T.-J. R Cheng, C.-Y. Wu,* J.-M. Fang,*C.-H. Wong*, 2014, “Chemical Constituents of Plectranthus amboinicus and the Synthetic Analogs Possessing Anti-inflammatory Activity”, BIOORGANIC & MEDICINAL CHEMISTRY, 22(5), 1766-1772. (SCIE)
  • A.-K. Sauer, C.-H. Liang, J. Stech, B. Peeters, P. Quéré, C. Schwegmann-Wessels,C.-Y. Wu, C.-H., 2014, “Characterization of the Sialic Acid Binding Activity of Influenza A Viruses Using Soluble Variants of the H7 and H9 Hemagglutinins”, PLoS One, 9(2), e89529. (SCIE)
  • Lou,Y.-W., Wang, P.-Y., Yeh, S.-C., Chuang, P.-K., Li, S.-T., Wu, C.-Y., Khoo, K.-H., Hsiao, M., Hsu, T.-L., Wong, C.-H.* , 2014, “Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, 2482-2487. (SCIE)
  • Juine-Ruey Che, 2014, “Vaccination of Monoglycosylated Hemagglutinin Induces Cross-Strain Protection against Influenza Virus Infections”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(7), 2476-2481. (SCIE)
  • Yen-Ju Chen; Mike W.C. Thang; Yu-Feng Huang; Yu-Tzu Chan; Nianhan Ma; Chung-Yi Wu; Miao-Lin Hu; Kuo Ping Chiu, 2013, “Global Assessment of Antrodia cinnamomea-induced MicroRNA Alterations in Hepatocarcinoma Cells”, PLoS One, 8(12), e82751. (SCIE)
  • Sachin S Shivatare, Shih-Huang Chang, Tsung-I Tsai, Chein-Tai Ren, Hong-Yang Chuang, Li Hsu, Chih-Wei Lin, Shiou-Ting Li, Chung-Yi Wu,* and Chi-Huey Wong*, 2013, “Efficient Convergent Synthesis of Bi-, Tri-, and Tetraantennary Complex Type N-Glycans and Their HIV-1 Antigenicity.”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(41), 15382-15391. (SCIE)
  • Tsung-I Tsai, Hsin-Yu Lee, Shih-Huang Chang, Chia-Hung Wang, Yu-Chen Tu, Yu-Chen Lin, Der-Ren Hwang, Chung-Yi Wu, Chi-Huey Wong*, 2013, “Effective Sugar Nucleotide Regenertion for the Large-scale Enzymatic Synthesis of Globo H and SSEA4”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(39), 14831-14839. (SCIE)
  • S.-F Liao, C.-H. Liang, M.-Y. Ho, T.-L. Hsu, T.-I. Tsai, Y.S.-Y. Hsieh, S.-T. Li, Y.-Y. Cheng, S.-M. Tsao, T.-Y. Lin, Z.-Y. Lin, W.-B. Yang, C.-T. Ren, K.-I. Lin, K.-H. Khoo, C.-H. Lin, H.-Y. Hsu*, C.-Y. Wu*, C.-H. Wong*, 2013, “Immunization of fucosucosucose-containing polysaccharides from Reishi mushroom induced antibodies against tumor-associated Globo H-series epitopes.”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(34), 13809-13814. (SCIE)
  • Hong-Yang Chuang, Chien-Tai Ren, Chung-An Chao, Chung-Yi Wu, Sachin S Shivatare, Ting-Jen R. Cheng,Chung-Yi Wu*, and Chi-Huey Wong*, 2013, “Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(30), 11140-11150. (SCIE)
  • Chia-Hung Wang, Shiou-Ting Li, Tzu-Lung Lin, Yang-Yu Cheng, Tsung-Hsien Sun, Jin-Town Wang, Ting-Jen R. Cheng, Kwok Kong Tony Mong, Chi-Huey Wong and Chung-Yi Wu*, 2013, “Synthesis of Neisseria meningitidis Serogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(35), 9157-9161. (SCIE)
  • C.-Y. Yang, J.-B. Chen, T.-F. Tsai, Y.-C. Tsai, C.-Y. Tsai, P.-H. Liang, T.-L. Hsu, C.-Y. Wu, C.-H. Wong, S.-L. Hsieh*, 2013, “CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver ”, PLoS One, 8(6), e65070. (SCIE)
  • S.-C. Lin, J.-T. Jan, B. Dionne, M. Butler, M.-H. Huang, C.-Y. Wu, C.-H. Wong, S.-C. Wu, 2013, “ Different Immunity Elicited by Recombinant H5N1 Hemagglutinin Proteins Containing Pauci-mannose, High-mannose, or Complex type N-Glycans.”, PLoS One, 8(6), e66719. (SCIE)
  • T.-C. Hung, C.-W. Lin, T.-L. Hsu, C.-Y. Wu, C.-H. Wong* , 2013, “Investigation of SSEA-4 Binding Protein in Breast Cancer Cells”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(16), 5934-5937. (SCIE)
  • Chia-Che Tsai, Chih-Ru Lin, Hsien-Yu Tsai, Chia-Jung Chen, Wen-Tai Li, Hui-Ming Yu, Yi-Yu Ke, Wei-Ying Hsieh, Cheng-Yen Chang, Chung-Yi Wu, Shui-Tein Chen,* Chi-Huey Wong , 2013, “The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(24), 17689-17697. (SCIE)
  • Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu*, C.-H. Wong*, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2517-22. (SCIE)
  • T.-J. R. Cheng, S.-Y. Wang, W.-H. Wen, C.-Y. Su, M. Lin, W.-I. Huang, M.-T. Liu, H.-S. Wu, N-S. Wang, C.-K. Cheng, C.-L. Chen, C.-T. Ren, C.-Y. Wu, J.-M. Fang,* Y.-S. E. Cheng* and C.-H. Wong*, 2013, “Chemical probes for drug resistance assessment by binding competition (RABC) oseltamivir susceptibility evaluation”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(1), 366-370. (SCIE)
  • Chu, K.-C.; Wu, C.-Y.*, 2012, “Carbohydrate-based synthetic vaccines: synthesis of longer chains of carbohydrates makes this a step ever closer?”, Future Medicinal Chemistry, 4(14),1767-1770. (SCIE)
  • Wu C.-H., Yen C.-J., Chou R.-H., Li S.-T., Huang W.-C., Ren C.-T., Wu C.-Y.*, Yu Y.-L.*, 2012, “Cancer-Associated Carbohydrate Antigens as Potential Biomarkers for Hepatocellular Carcinoma.”, PLoS One, 7, e39466. (SCIE)
  • Chung-Yi Wu; Hui-Chang Lin; Hsien-Jen Wu, 2012, “Sythesis of New Acetal Aza-Cage Compounds via Ozonolysis of Bis-endo-diol- and Diacylnornornese Derivatives”, TETRAHEDRON, 68, 2100-2106. (SCIE)
  • D Punyadarsaniya, C-H Liang, C Winter, H Petersen, S Rautenschlein, I Hennig-Pauka, C Schwegmann-Wessels, C-Y Wu, C-H Wong, G Herrler* , 2011, “Infection of differentiated porcine airway epithelial cells by influenza virus: differential susceptibility to infection by porcine and avian viruses”, PLoS One, 6(12), e28429. (SCIE)
  • Che-Hsiung Hsu, Shang-Cheng Hung*, Chung-Yi Wu*, and Chi-Huey Wong*, 2011, “Toward Automated Oligosaccharide Synthesis”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(50), 11872-11923. (SCIE)
  • K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, J.-L. Han, B. Pal, T.-A. Chao, S.-H. Wu, C.-H. Wong* and C.-Y. Wu*, 2011, “Efficient and Stereoselective Synthesis of alpha(2→9) Oligosialic Acids: From Monomers to Dodecamers”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 9391-9395. (SCIE)
  • H-L Yen, C-H Liang, C-Y Wu, H Forrest, A Ferguson, KT Choy, J Jones, DDY Wong, PPH Cheung, C-H Hsu, OT Li, KM Yuen, RWY Chan, LLM Poon, MCW Chan, J Nicholls, S Krauss, C-H Wong, Y Guan, RG Webster, RJ Webby & JSM Peiris* , 2011, “Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 14264-14269. (SCIE)
  • Bin-Ling Tsai, Jeng-Liang Han, Chien-Tai Ren, Chung-Yi Wu* and Chi-Huey Wong*, 2011, “Programmable One-Pot Synthesis of Lewis X dimer and KH-1 epitopes”, TETRAHEDRON LETTERS, 52(17), 2132-2135. (SCIE)
  • Chen MW, Liao HY, Huang Y, Jan JT, Huang CC, Ren CT, Wu CY, Cheng TJ, Ho DD, Wong CH, 2011, “Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglut”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(9), 3510-3515. (SCIE)
  • Chung-Yi Wu* and Chi-Huey Wong*, 2011, “Chemistry and Glycobiology”, CHEMICAL COMMUNICATIONS, 47, 6201-6207. (SCIE)
  • Liang, C.-H., Wang, S.-K., Lin, C.-W., Wong, C.-H.*, Wu, C.-Y.*, 2011, “Effects of neighboring glycans on antibody-carbohydrate interaction”, Angewandte chemie-international edition, 50(7), 1608-1612. (SCIE)
  • Chung-Yi Wu* and Chi-Huey Wong*, 2011, “Programmable One-Pot Glycosylation”, Topics in Current Chemistry, 301, 223-252. (SCIE)
  • Y.-L. Huang, C.-Y. Wu*, 2010, “Carbohydrate-Based Vaccines: Challenges and Opportunities”, Expert review of vaccines, 9 (11), 1257-1274. (SCIE)
  • Chen-I Wu, Yi-Sheng Wang, Nelson G. Chen, Chung-Yi Wu and Chung-Hsuan Chen*, 2010, “Ultrasound Ionization of Biomolecules”, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 24, 2569-2574. (SCIE) (IF: 2.2; SCI ranking: 50%,59.7%,35.7%)
  • Liang, C.-H.; Wu, C.-Y.*, 2010, “Glycomics: Relevance for Personalized Medicine”, Current Pharmacogenomics and Personalized Medicine, 8, 49-63.
  • Hsu, C.-H.; Chu, K.-C.; Lin, Y.-S.; Han, J.-L.; Peng, Y.-S.; Ren, C.-T.; Wu, C.-Y.* and Wong, C.-H.*, 2010, “Highly Alpha-Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides.”, Chemistry-A European Journal, 16(6), 1754-1760. (SCIE)
  • Liao H-Y, Hsu C-H, Wang S-C, Liang C-H, Ye H-Y, Su C-Y, Jan J-T, Ren C-T, Cheng T.-J R,* Wu C-Y*, Wong C-H*, 2010, “Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays”, Journal of the American Chemical Society, 132, 14849-14856. (SCIE)
  • Shih-Huang Chang, Jeng-Liang Han, Susan Y. Tseng, Hsin-Yu Lee, Chin-Wei Lin, Yu-Chen Lin, Wen-Yih Jeng, Andrew H.-J. Wang, Chung-Yi Wu,* Chi-Huey Wong*, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides through Phosphonate Chemistry”, Journal of the American Chemical Society, 132, 13371-13380. (SCIE)
  • Liang C-H, Wu,C-Y*, 2009, “Glycan Array: A Powerful Tool for Glycomics Studies”, Expert Review of Proteomics, 6(6), 631-645. (SCIE)
  • Wang, C.-C.; Chen, J.-R.; Tseng, Y.-C.; Hsu, C.-H.; Hung, Y.-F.; Chen, S.-W.; Chen, C.-M.; Khoo, K.-H.; Cheng, T.-J.; Cheng, Y.-S.; Jan, J.-T.; Wu, C-Y., Ma, A.C.*; Wong, C-H*, 2009, “Glycans on influenza hemagglutinin affect receptor binding and immune response ”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(43), 18137-18142. (SCIE)
  • Chi-Hui Linag,Cheng-Chi Wang,Yu-Chen Lin,Chung-Hsuan Chen,Chi-Huey Wong*,Chung-Yi Wu*, 2009, “Iron Oxide/Gold Core/Shell Nanoparticle for Ultrasensitive Detection of Carbohydrate-Protein Interactions”, Analytical Chemistry, 81, 7750-7756. (SCIE)
  • Chung-Yi Wu*, Pi-Hui Liang*, Chi-Huey Wong*, 2009, “New development of glycan arrays”, ORGANIC & BIOMOLECULAR CHEMISTRY, 7(11), 2247-2254. (SCIE)
  • Wang, S. Y.; Su, C. Y.; Lin, M.; Huang, S. Y.; Huang, W. I.; Wang, C. C.; Wu, Y. T.; Cheng, T. J. R.; Yu, H. M.; Ren, C. T.; Chung-Yi Wu.; Wong, C. H.; Cheng, Y. S. E.*, 2009, “HA-pseudotyped retroviral vector for influenza antagonist screening.”, Journal of Biomolecular Screening, 14(3), 294-302.
  • Susan Y. Tseng, Cheng-Chi Wang, Chin-Wei Lin, Cheng-Lung Chen, Wen-Yueh Yu, Chung-Hsuan Chen, Chung-Yi Wu*, Chi-Huey Wong*, 2008, “Glycan arrays on aluminum-coated glass slides.”, CHEMISTRY-AN ASIAN JOURNAL, 3(8-9), 1395-1405.. (SCIE)
  • Pi-Hui Liang, Chung-Yi Wu, William A. Greenberg, Chi-Huey Wong*, 2008, “Glycan arrays: biological and medical applications.”, CURRENT OPINION IN CHEMICAL BIOLOGY, 12(1), 86-92 2008. (SCIE)
  • Nien-Yeen Hsu, Susan Yu Tseng, Chung-Yi Wu, Chien-Tai Ren, Yuan-Chang Lee, Chi-Huey Wong, Chung-Hsuan Chen*, 2008, “Desorption ionization of biomolecules on metals.”, ANALYTICAL CHEMISTRY, 80(13), 5203-5210. (SCIE)
  • Cheng-Chi Wang,Yen-Lin Huang, Chien-Tai Ren, Chin-Wei Lin, Jung-Tung Hung, Jyh-Cherng Yu, Alice L. Yu*, Chung-Yi Wu*, Chi-Huey Wong*, 2008, “Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer. ”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(33), 11661-11666. (SCIE)
  • C. W. Ho, Y. N. Lin, C. F. Chang, H. T. Lee, Y. T.Wu, C. Y. Wu, S.W. Liu, Y.K. Li and C. H. Lin*, 2006, “Discovery of Different Types of Inhibition between the Human and Thermotoga maritime α-Fucosidases by Fuconojirimycin-Based Derivatives”, Biochemistry, 45, 5695-5702. (SCIE)
  • A. Brik, C.Y. Wu, C. H. Wong*, 2006, “Microtiter Plate Based Chemistry and In Situ Screening: A Useful Approach for Rapid Inhibitors Discovery”, ORGANIC & BIOMOLECULAR CHEMISTRY, 4, 1446-1457. (SCIE)
  • J.C. Lee, Chung-Yi Wu, J.V. Apon, G. Siuzdak and C.H. Wong, 2006, “Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photocleavable DIOS-MS sugar array”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 45, 2753-2757. (SCIE)
  • Chung-Yi Wu, K. Y. King, C. J. Kuo, J. M. Fang, Y. T. Wu, M. Y. Ho, C. L. Liao, J. J. Shie, P. H. Liang and C. H. Wong, 2006, “Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Stndrome 3CL Protease”, Chem Biol, 13, 261-268.
  • Ashraf Brik, Chung-Yi Wu, M. D Best,Chi-Huey Wong*, 2005, “Tetrabutylammonium fluoride-assisted rapid N(9)-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ.”, BIOORGANIC & MEDICINAL CHEMISTRY, 13(15), 4622-4626. (SCIE)
  • C. Y. Wu, A. Brik, S. K. Wang, Y. H. Chen and C. H. Wong, 2005, “Tetrabutylammonium Fluoride-Mediated Rapid Alkylation Reaction in Microtiter Plates for Discovery of Enzyme Inhibitors in Situ”, Chembiochem, 6, 2176-2180. (SCIE)
  • C. F. Chang, C. W. Ho, Chung-Yi Wu, T. A. Chao, C. H. Wong*, C. H. Lin*, 2004, “Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.”, Chem Biol, 11(9), 1301-1306.
  • Chung-Yi Wu, J. T. Jan*, S. H. Ma, C. J. Kuo, H. F. Juan, Y. H. E. Cheng, H. H. Hsu, R. H. Liu, J. M. Fang, P. H. Liang and C. H. Wong*, 2004, “Small molecules targeting Severe Acute Respiratory Syndrome (SARS) human coronavirus”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 10012-10017. (SCIE)
  • Chung-Yi Wu, C. F. Chang, J. S. Y. Chen, C. H. Wong*, C. H. Lin*, 2003, “Rapid Diversity-Oriented Synthesis in Microtiter Plates for in situ Screening: Discovery of Potent and Selective a-Fucosidase Inhibitors”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 42(38), 4661-4664. (SCIE)
  • Hui-Chang Lin, Wen-Bin Yang, Yu-Feng Gu, Chen-Yin Chen, Chung-Yi Wu, Chun-Hung Lin, 2003, “Stereoselective Glycosylation of exo-Glycals Accelerated by Ferrier-Type Rearrangement.”, ORGANIC LETTERS, 5(7), 1087-1089. (SCIE)
  • W.-B Yang, Chung-Yi Wu, C.-C. Chang, S.-H. Wang, C.-F. Teo, C.-H. Lin*, 2001, “Facial Synthesis of Conjugated Exo-Glycals”, TETRAHEDRON LETTERS, 42, 6907-6910. (SCIE)
  • Chung-Yi Wu, H. C. Lin, Z. Y. Wang, H. J. Wu*, 2001, “Synthesis of Novel Acetal Thia-Cage Compounds.”, JOURNAL OF ORGANIC CHEMISTRY, 66, 4610-4618. (SCIE)
  • H. J. Wu*, Chung-Yi Wu, 1999, “Synthesis of Pentaoxa[5]peristylanes”, JOURNAL OF ORGANIC CHEMISTRY, 64, 1576-1584. (SCIE)
  • H.-J. Wu*, J.-H. Chern, Chung-Yi Wu, 1997, “Ozonolysis of 2-endo-7-anti-Diacylnorbornenes. A new Entry for The Synthesis of 2,4,6,13-Tetraoxapentacyclo[,11).0(5,9).0(8,12)]tridecanes”, TETRAHEDRON, 53, 2401-2414.. (SCIE)
  • H.-C. Lin*, Chung-Yi Wu, H.-J. Wu*, 1997, “Synthesis of 3,11-Dioxatetracyclo[,6).0(5,9)]undecanes and 3,5,7-trioxapentacyclo[,8).0(4,11).0(6,10)]dodecane.”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 44, 609-616. (SCIE)
  • Chung-Yi Wu, Hsien-Jen Wu*, 1997, “The Pentaoxa[5]peristylanes. A Novel Oxa-Cage System”, TETRAHEDRON LETTERS, 38, 2493-2496. (SCIE)
  • H.-J. Wu*, Chung-Yi Wu, C.-C. Lin, 1996, “Syntheisi of Novel triacetal oxa-cage compounds”, Chinese Chemistry Letters, 7, 15-18.
  • C. Y. Wu; C. C. Lin; M. C. Lai; H. J., 1996, “Synthesis of Novel Triacetal Trioxa-Cage Compounds by Ozonolysis of Bicyclo[2.2.1]heptenes and Bicycle[2.2.2]octenes”, Journal of the Chinese Chemical Society, 43, 187-194. (SCIE)
  • R.-L. Lin, Chung-Yi Wu, J.-H, Chern, H.-J. Wu, 1996, “Synthesis of Tetraacetal Tetraoxa-Cage Compounds with Alkyl Substituents at Different Sites of The Oxa-Cage Skeleton”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 43, 289-295. (SCIE)