Wong, Chi-Huey

WongCH6x7Distinguished Professor


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+886-2-27899929

 

 

 

EDUCATION AND POSITIONS HELD:

  • Ph.D. in Chemistry, MIT, 1979-1982
  • Postdoctoral Fellow, Harvard University, 1982–1983
  • Assistant Professor through Professor of Chemistry, Texas A&M University, 1983–1989
  • Professor and Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 1989–2006.
  • Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 1996–2006.
  • Head, Frontier Research Program on Glycotechnology, Institute of Physical and Chemical Research (RIKEN), Japan, 1991–1999.
  • Distinguished Professor, Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2003–present
  • Director, The Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2003–2006.
  • President, Academia Sinica, Taipei, Taiwan, 2006-2016.
  • Scripps Family Chair Professor, Department of Chemistry, The Scripps Research Institute, La Jolla, California, 2019-present

HONORS:

  • Searle Scholar Award in Biomedical Sciences, 1985
  • Presidential Young Investigator in Chemistry, 1986
  • The IUPAC International Carbohydrate Award, 1994
  • Elected Member of Academia Sinica, Taipei, 1994
  • Elected Member of the American Academy of Arts and Sciences, 1996
  • American Chemical Society Harrison Howe Award in Chemistry, 1998
  • American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry, 1999
  • The International Enzyme Engineering Award, 1999
  • Presidential Green Chemistry Award, USA, 2000
  • Elected Member of the National Academy of Sciences, USA 2002
  • American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 2005
  • The F. A. Cotton Medal for Excellence in Chemical Research, 2008
  • Editor-in-Chief, Bioorganic & Medicinal Chemistry, 1993–2010
  • Elected Associate Member of the European Molecular Biology Organization (EMBO), 2010
  • The American Chemical Society Arthur C. Cope Award, 2012
  • Nikkei Asia Prize for Science, Technology and Innovation, 2012
  • The Wolf Prize in Chemistry, 2014
  • Elected Fellow of the U.S. National Academy of Inventors, 2014
  • The Royal Society of Chemistry Robert Robinson Award, UK, 2015
  • Welch Award in Chemistry, 2021

RESEARCH INTERESTS:

Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Current interest is centered on the development of discovery tools for understanding the role of biological glycosylation in cancer progression, bacterial and viral infection, neurodegenerative disorder and immune response. Programmable one-pot synthesis as well as chemo-enzymatic synthesis of oligosaccharides and homogeneous glycoproteins, and design of glycan microarrays and glycosylation probes are among the tools being developed for the study of cell-surface glycoconjugates. The ultimate goal of our research is to identify novel glycan targets for therapeutic development, including the development of carbohydrate-based vaccines, homogeneous antibodies with optimized effector functions, and inhibitors of key enzymes involved in the biosynthesis of glycan targets.

Our main focus is to develop new tools for understanding the role of biological glycosylation in the development of diseases with an ultimate goal of developing new therapeutic strategies to combat them.

cell-surface-1-CH-Wong

SELECTED PUBLICATIONS:

  • C.-W. Chang, M.-H. Lin, C.-K. Chan, K.-Y. Su, C.-H. Wu, W.-C. Lo, S. Lam, Y.-T. Cheng, P.-H. Liao, C.-H. Wong, C.-C. Wang, 2021, “Automated Quantification of Hydroxyl Reactivities: Prediction of Glycosylation Reactions.”, Angewandte Chemie (International ed. in English), DOI: 10.1002/anie.202013909.
  • J.-T. Jan, T.-J. R. Cheng, Y.-P. Juang, H.-H. Ma, Y.-T. Wu, W.-B. Yang, C.-W. Cheng, X. Chen, T.-H. Chou, J.-J. Shie, W.-C. Cheng, R.-J. Chein, S.-S. Mao, P.-H. Liang, C. Ma, S.-C. Hung and C.-H. Wong, 2021, “Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection.”, Proceedings of the National Academy of Sciences of the United States of America, 118(5), e2021579118. (SCIE)
  • V. Gannedi, B. Villuri, S. Reddy, C.-C. Ku, C.-H. Wong, S.-C. Hung, 2021, “Practical Remdesivir Synthesis through One-Pot Organocatalyzed Asymmetric (S)-P-Phosphoramidation.”, The Journal of organic chemistry, 86(7), 4977–4985. (SCIE)
  • Y.-M. Liu, M. Shahed-Al-Mahmud, X. Chen, T.-H. Chen, K.-S. Liao, J. M. Lo, Y.-M Wu., M.-C. Ho, C.-Y. Wu, C.-H. Wong, J.-T. Jan, C. Ma, 2020, “A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2”, Cell Reports, 32(6), 108016. (SCIE)
  • H.-Y. Liao, S.-C. Wang, Y.-A. Koa, K.-I. Lin, C. Ma, T.-J. R. Cheng, and C.-H. Wong, 2020, “Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes”, Proceedings of the National Academy of Sciences, 117(30), 17757-17763.
  • Y.-H. Chang, J.-C. Wu, H.-M. Yu, H.-T. Hsu, Y.-T. Wu, A. L.-T. Yu, C.-D. T. Yu and C.-H. Wong, 2020, “Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction”, Chemical Communications, 56(43), 5827-5830. (SCIE)
  • J. Woodring, S.-H. Lu, L. Krasnova, S.-C. Wang, J.-B. Chen, C.-C. Chou, Y.-C. Huang, T.-J. Cheng, Y.-T. Wu, Y.-H. Chen, J.-M. Fang, M.-D. Tsai, C.-H. Wong, 2020, “Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein”, Journal of Medicinal Chemistry, 63(1), 205-215. (SCIE)
  • W.-F. Wang, M.-Y. Jade Lu, T.-J. R. Cheng, Y.-C. Tang, Y.-C. Teng, T.-Y. Hwa, Y.-H. Chen, M.-Y. Li, M.-H. Wu, P.-C. Chuang, R. Jou, C.-H. Wong, and W.-H. Li, 2020, “Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome”, Genome Biology and Evolution, 12(2), 3890-3905. (SCIE)
  • C.-Y. Wu, H.-Y. Chuang, C.-H. Wong, 2020, “Influenza virus neuraminidase regulates host CD8(+) T-cell response in mice.”, Communications biology, 3(1), 748. (SCIE)
  • E. A. Wang, W.-Y. Chen, C.-H. Wong, 2020, “Multiple Growth Factor Targeting by Engineered Insulin-like Growth Factor Binding Protein-3 Augments EGF Receptor Tyrosine Kinase Inhibitor Efficacy”, Scientific Reports, 10(1), 2735. (SCIE)
  • S. Dey, H.-J. Lo, C.-H. Wong,, 2020, “Programmable One-Pot Synthesis of Heparin Pentasaccharide Fondaparinux”, Organic Letters, 22(12), 4638-4642. (SCIE)
  • C.-W. Cheng, C.-Y. Wu, W.-L. Hsu, C.-H. Wong, 2020, “Programmable One-Pot Synthesis of Oligosaccharides”, Biochemistry, 59(34), 3078-3088. (SCIE)
  • C.-Y. Lin, H.-Y. Wu, P.-S. Wu, Y.-L. Hsu, T.-J. Cheng, J.-H. Liu, R.-J. Huang, T. H. Hsiao, C.-J. Wang, P.-F. Hung, A. Lan, Y.-J. Chen, S.-H. Pan, R.-J. Chein, C.-H. Wong, P.-C. Yang, 2020, “Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein”, Journal of Medicinal Chemistry, 63(6), 3172-3187. (SCIE)
  • S. Pawar, L. Hsu, T. N. Reddy, M. Ravinder, C.-T. Ren, Y.-W. Lin, Y.-Y. Cheng, T.-W. Lin, T.-L. Hsu, S.-K. Wang, C.-H. Wong, C.-Y. Wu, 2020, “Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation”, ACS Chemical Biology, 15(9), 2382-2394. (SCIE)
  • S. Shivatare, C.-H. Wong, 2020, “Synthetic Carbohydrate Chemistry and Translational Medicine.”, The Journal of organic chemistry, 85(24), 15780-15800. (SCIE)
  • L.-T. Chiu, N. Sabbavarapu, W.-C. Lin, C.-Y. Fang, C.-C. Wu, T.-J. Cheng, C.-H. Wong, S.-C. Hung, 2020, “Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1”, Journal of the American Chemical Society, 142(11), 5282-5292. (SCIE)
  • C.-F. Huang, W.-H. Chang, T.-K. Lee, Y. Joti, Y. Nishino, T. Kimura, A. Suzuki, Y. Bessho,T.-T. Lee, M.-C. Chen, S.-M. Yang, Y. Hwu, S.-H. Huang, P.-N. Lee, P. Chen, Y.-C. Tseng, C. Ma, T.-L. Hsu, C.-H. Wong, K. Tono, T. Ishikawa, and K. Liang, 2020, “XFEL coherent diffraction imaging for weakly scattering particles using heterodyne interference”, AIP Advances, 10(5), 055219. (SCIE)
  • H.-J. Lo, L. Krasnova, S. Dey, T. Cheng, H. Liu, T.-I. Tsai, K. B. Wu, C.-Y. Wu, and C.-H. Wong, 2019, “Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing alpha2,6-Linked 3F(ax)-Neu5Ac.”, Journal of the American Chemical Society, 141(16), 6484-6488. (SCIE)
  • Y.-C. Tseng, C.-Y. Wu, M.-L. Liu, T.-H. Chen, W.-L. Chiang, Y.-H. Yu, J.-T. Jan, K.-I. Lin, C.-H. Wong and C. Ma, 2019, “Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections.”, Proceedings of the National Academy of Sciences of the United States of America, 116(10), 4200-4205. (SCIE)
  • L. Krasnova and C.-H. Wong, 2019, “Oligosaccharide Synthesis and Translational Innovation.”, Journal of the American Chemical Society, 141(9), 3735-3754. (SCIE)
  • P.-K. Chuang, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-Y. Wu, B.-R. Chen, H.-W. Huang, K.-S. Liao, C.-C. Chen, C.-L. Chen, S.-M. Yang, C. W. Kuo, P. Chen, P.-T. Chiu, I.-J. Chen, J.-S. Lai, C.-D. T. Yu, and C.-H. Wong, 2019, “Signaling pathway of globo-series glycosphingolipids and beta1,3-galactosyltransferase V (beta3GalT5) in breast cancer.”, Proceedings of the National Academy of Sciences of the United States of America, 116(9), 3518-3523. (SCIE)
  • S.-C. Wang, H.-Y. Liao, J.-Y. Zhang, T.-J. R. Cheng, C.-H. Wong, 2019, “Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris”, VIROLOGY, 526, 125-137. (SCIE)
  • M.-S. Lin,T.-M. Hong, T.-H. Chou, S.-C. Yang, M.-C. Chung, C.-W. Weng, M.-L. Tsai, T.-R. Cheng, J.-J.-W., T.-C. Lee, C.-H. Wong, R.-J. Chein, P.-C. Yang, 2019, “4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin”, European Journal of Medicinal Chemistry, 181, 111584. (SCIE)
  • S. Dey, H.-J. Lo, C.-H. Wong, 2019, “An Efficient Modular One-Pot Synthesis of Heparin-Based Anticoagulant Idraparinux”, Journal of the American Chemical Society, 141(26), 10309-10314. (SCIE)
  • M.-S. Lin,T.-M. Hong, T.-H. Chou, S.-C. Yang, M.-C. Chung, C.-W. Weng, M.-L. Tsai, T.-R. Cheng, J.-J.-W., T.-C. Lee, C.-H. Wong, R.-J. Chein, P.-C. Yang, 2019, “Hierarchical and Programmable One-Pot Oligosaccharide Synthesis”, Journal of Visualized Experiments, 151, e59987.
  • C.-H. Wong and L. Krasnova, 2019, “Highlights in chemical glycobiology”, Israel Journal of Chemistry, 59, 18-22. (SCIE)
  • M.-R. Huang, Y.-L. Hsu, T.-C. Lin, T.-J. Cheng, L.-W. Li, W.-W. Tseng, Y.-S. Chou, J.-H. Liu, S.-H. Pan, J.-M. Fang, C.-H. Wong, 2019, “Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer”, European Journal of Medicinal Chemistry, 181, 111551. (SCIE)
  • X. Chen, C.-H. Wong, C. Ma, 2019, “Targeting the Bacterial Transglycosylase: Antibiotic Development from a Structural Perspective”, ACS Infectious Diseases, 5(9), 1493-1504. (SCIE)
  • H.-W. Cheng, R.-J. Chein, T.-J. Cheng, P.-S. Wu, H.-Y. Wu, P.-F. Hung, C.-J. Wang, Y.-L. Hsu, J.-M. Wong, A. Yuan, C.-H. Wong, P.-C. Yang, S.-H. Pan, 2018, “2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction.”, Cancer science, 109(3), 832-842. (SCIE)
  • T. Zhou, A. Zheng, U. Baxa, G.-Y. Chuang, I. S. Georgiev, R. Kong, S. O’Dell, S. Shahzad-ul-Hussan, C.-H. Shen, Y. Tsybovsky, R. T. Bailer, S. K. Gift, M. K. Louder, K. McKee, R. Rawi, C. H. Stevenson, G. B. E. Stewart-Jones, J. D. Taft, E. Waltari, Y. Yang, B. Zhang, S. S. Shivatare, V. S. Shivatare, C.-C. D. Lee, C.-Y. Wu, NISC Comparative Sequencing Program, J. C. Mullikin, C. A. Bewley, D. R. Burton, V. R. Polonis, L. Shapiro, C.-H. Wong, J. R. Mascola, P. D. Kwong, and X. Wu, 2018, “A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.”, Immunity, 48(3), 500-513.e6. (SCIE)
  • W.-S. Wu, W.-C. Cheng, T.-R. Cheng, C.-H. Wong, 2018, “Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.”, Journal of the American Chemical Society, 140(8), 2752-2755. (SCIE)
  • S. S. Shivatare, V. S. Shivatare, C.-Y. Wu, C.-H. Wong, 2018, “Chemo-Enzymatic Synthesis of N-Glycans for Array Development and HIV Antibodies Profiling”, Jove-Journal of Visualized Experiments, 132. (SCIE)
  • S. S. Shivatare, L.-Y. Huang, Y.-F. Zeng, J.-Y. Liao, T.-H. You, S.-Y. Wang, T. Cheng, C.-W. Chiu, P. Chao, L.-T. Chen, T.-I. Tsai, C.-C. Huang, C.-Y. Wu, N.-H. Lin, and C.-H. Wong, 2018, “Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies”, CHEMICAL COMMUNICATIONS, 54(48), 6161-6164. (SCIE)
  • C.-F. Huang, K. S. Liang, T.-L. Hsu, T.-T. Lee, Y.-Y. Chen, S.-M. Yang, H.-H. Chen, S.-H. Huang, W.-H. Chang, T.-K. Lee, P. Chen, K.-E. Peng, C.-C. Chen, C.-Z. Shi, Y.-F. Hu, G. Margaritondo, T. Ishikawa, C.-H. Wong and Y. Hwu, 2018, “Free-electron-laser coherent diffraction images of individual drug-carrying liposome particles in solution.”, Nanoscale, 10(6), 2820-2824. (SCIE)
  • C.-P. Liu, T.-I Tsai, T. Cheng, V. S. Shivatare, C.-Y. Wu, C.-Y. Wu, C.-H. Wong, 2018, “Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation.”, Proceedings of the National Academy of Sciences of the United States of America, 115(4), 720-725. (SCIE)
  • C.-W. Cheng, Y. Zhou, W.-H. Pan, S. Dey, C.-Y. Wu, W.-L. Hsu, and C.-H. Wong, 2018, “Hierarchical and programmable one-pot automated synthesis of oligosaccharides”, Nature Communications, 9, 5202. (SCIE)
  • P.-W. Lo, J.-J. Shie, C.-H. Chen, C.-Y. Wu, T.-L. Hsu, C.-H. Wong, 2018, “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2”, Proceedings of the National Academy of Sciences of the United States of America, 115(28), 7302-7307. (SCIE)
  • S. Dey and C.-H. Wong, 2018, “Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives”, Chemical Science, 9(32), 6685-6691. (SCIE)
  • S. Dey, S. O. Bajaj, T.-I. Tsai, H.-J. Lo, K. Wu, and C.-H. Wong, 2018, “Synthesis of Modular Building Blocks using Glycosyl Phosphate Donors for the Construction of Asymmetric N-Glycans”, TETRAHEDRON, 74(41), 6003-6011. (SCIE)
  • X. Wang, L. Krasnova, K. B. Wu, W.-S. Wu, T.-J. Cheng, C.-H. Wong, 2018, “Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor.”, Bioorganic & Medicinal Chemistry Letters, 28(16 SI), 2708-2712. (SCIE)
  • V. S. Shivatare, S. S. Shivatare, C.-C. Lee, C.-H. Liang, K.-S. Liao, Y.-Y. Cheng, G. Saidachary, C.-Y. Wu, N.-H. Lin, P. D. Kwong, D. Burton, C.-Y. Wu, C.-H. Wong, 2018, “Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.”, Journal of the American Chemical Society, 140(15), 5202-5210. (SCIE)
  • Y. Kizuka, M. Nakano, Y. Yamaguchi, K. Nakajima, R. Oka, K. Sato, C.-T. Ren, T.-L. Hsu, C.-H. Wong, N. Taniguchi, 2017, “An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3.”, Cell chemical biology, 24(12), 1467-1478.e5. (SCIE)
  • C.-L. Chen, J.-C. Hsu, C.-W. Lin, C.-H. Wang, M.-H. Tsai, C.-Y. Wu, C.-H. Wong, C. Ma, 2017, “Crystal structure of a homogeneous IgG-Fc glycoform with the N-glycan designed to maximize the antibody dependent cellular cytotoxicity”, ACS Chemical Biology, 12(5), 1335-1345. (SCIE)
  • W. Yang, D. Punyadarsaniya, R. Lambertz, D. Lee, C.-H. Liang, D. Höper, S. Leist, A. Hernandez-Caceres, J. Stech, M. Beer, C.-Y. Wu, C.-H. Wong, K. Schughart, F. Meng, and G. Herrler, 2017, “Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice”, JOURNAL OF VIROLOGY, 91(8), e02125-16. (SCIE)
  • J.-J. Shie, Y.-C. Liu, J.-C. Hsiao, J.-M. Fang, C.-H. Wong, 2017, “A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells”, CHEMICAL COMMUNICATIONS, 53(9),1490-1493. (SCIE)
  • T.-I. Tsai, S.-T. Li, C.-P. Liu, K. Chen, S. S. Shivatare, C.-W. Lin, S.-F. Liao, C.-W. Lin, T.-L. Hsu, Y.-T. Wu, M.-H. Tsai, M-Y. Lai, N.-H. Lin, C.-Y. Wu, C.-H. Wong, 2017, “An Effective Bacterial Fucosidase for Glycoprotein Remodeling”, ACS Chemical Biology, 12(1), 63-72. (SCIE)
  • C.-Y. Wu, C.-W. Lin, T.-L. Tsai, C.-C. D. Lee, H.-Y. Chuang, J.-B. Chen, M.-H. Tsai, B.-R. Chen, P.-W. Lo, C.-P. Liu, V. S. Shivatare and C.-H. Wong, 2017, “Influenza A surface glycosylation and vaccine design.”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(2), 280-285. (SCIE)
  • A. M. Stax, J. Tuengel, E. Girardi, N. Kitano, L. L. Allan, J. I. Alvarez, V. Li, D. Zheng, W. J. Panenka, C.-H. Wong, S. van Calenbergh, D. M. Zajonc, P. van den Elzen, 2017, “Autoreactivity to Sulfatide by Human Invariant NKT Cells.”, JOURNAL OF IMMUNOLOGY, 199(1), 97-106. (SCIE)
  • C.-Y. Ting, Y.-W. Lin, C.-Y. Wu, C.-H. Wong, 2017, “Design of Disaccharide Modules for a Programmable One-Pot Synthesis of Building Blocks with LacNAc Repeating Units for Asymmetric N-Glycans”, Asian Journal of Organic Chemistry, 6(12), 1800-1807. (SCIE)
  • R. Andrabi, C.-Y. Su, C.-H. Liang, S.-S. Shivatare, B. Briney, J. E. Voss, S. K. Nawazi, C.-Y. Wu, C.-H. Wong, D. R. Burton, 2017, “Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development.”, Immunity, 47(5), 1004. (SCIE)
  • Y.-W. Huang, H.-I. Yang, Y.-T. Wu, T.-L. Hsu, T.-W. Lin, J. Kelly, C.-H. Wong, 2017, “Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency.”, Journal of the American Chemical Society, 139(37), 12947-12955. (SCIE)
  • T. H. Tseng, T.-W. Lin, C.-Y. Chen, C.-H. Chen, J.-L. Lin, T.-L. Hsu, C.-H. Wong, 2017, “Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases.”, Journal of the American Chemical Society, 139(28), 9431-9434. (SCIE)
  • L.-Y. Huang, S.-C. Wang, T.-J. R. Cheng, C.-H. Wong, 2017, “Undecaprenyl Phosphate Phosphatase Activity of Undecaprenol Kinase Regulates the Lipid Pool in Gram-Positive Bacteria.”, Biochemistry, 56(40), 5417-5427. (SCIE)
  • S. Y. Tseng, W.-H. Cho, J. Su, S.-H. Chang, D. Chiang, C.-Y. Wu, C.-N. Hsiao, C.-H. Wong, 2016, “Preparation of Aluminum Oxide-Coated Glass Slides for Glycan Microarrays”, ACS Omega, 1(5), 773–783. (SCIE)
  • D. Sok, M. Pauthner, B. Briney, J.-H. Lee, K. L.Saye-Francisco, J. Hsueh, A. Ramos, K.-M. Le, M. Jones, J. G. Jardine, R. Bastidas, A. Sarkar, C.-H. Liang, S. S. Shivatare, C.-Y. Wu, W. R. Schief, C.-H. Wong, I. A. Wilson, A. B. Ward, J. Zhu, P. Poignard, D. R. Burton, 2016, “A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.”, Immunity, 45(1), 31-45. (SCIE)
  • Y.-L. Lo, G.-G. Liou, C.-H. Lu, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2016, “Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex.”, PloS one, 11(11), e0166474. (SCIE)
  • D. T. MacLeod, N. M. Choi, B. Briney, F. Garces, L. S. Ver, E. Landais, B. Murrell, T. Wrin, W. Kilembe, C.-H. Liang, A. Ramos, C.-B. Bian, L. Wickramasinghe, L. Kong, K. Eren, C.-Y. Wu, C.-H. Wong, S. L. Kosakovsky Pond, I. A. Wilson, D. R. Burton, P. Poignard,, 2016, “Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch.”, Immunity, 44(5), 1215-1226. (SCIE)
  • L. Krasnova and C.-H. Wong, 2016, “Exploring human glycosylation for better therapies.”, MOLECULAR ASPECTS OF MEDICINE, S0098-2997. (SCIE)
  • S.-C. Yeh, P.-Y. Wang, Y.-W. Lou, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2016, “Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity.”, Proceedings of the National Academy of Sciences of the United States of America, 113(20), 5592-5597. (SCIE)
  • Y. Kizuka, S. Funayama, H. Shogomori, M. Nakano, K. Nakajima, R. Oka, S. Kitazume, Y. Yamaguchi, M. Sano, H. Korekane, T.-L. Hsu, H.-Y. Lee, C.-H. Wong and N. Taniguchi, 2016, “High-Sensitivity and Low-Toxicity Fucose Probe for Glycan Imaging and Biomarker Discovery.”, Cell Chemical Biology, 23(7), 782-792. (SCIE)
  • S. S. Shivatare, S.-H. Chang, T.-I. Tsai, S. Y. Tseng, Y.-S. Lin, Y.-Y. Cheng, C.-T. Ren, S. Pawar, C.-S. Tsai, H.-W. Shi, Y.-F. Zeng, C.-H. Liang, P. D. Kwong, D. R. Burton, C.-Y. Wu and C.-H. Wong, 2016, “Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies”, Nature Chemistry, 8(4), 338-346. (SCIE)
  • P.-C. Wang, J.-M. Fang, K.-C. Tsai, S.-Y. Wang, W.-I. Huang, Y.-S. Cheng, R. C., C.-H. Wong, 2016, “Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors.”, Journal of medicinal chemistry, 59(11), 5297-5310. (SCIE)
  • T.-N. Wu, K.-H. Lin, Y.-T. Wu, J.-R. Huang, J.-T. Hung, J.-C. Wu, C.-Y. Chen, K.-C. Chu, N.-H. Lin, A. L.Yu, C.-H. Wong, 2016, “Phenyl Glycolipids with Different Glycosyl Groups Exhibit Marked Differences in Murine and Human iNKT Cell Activation.”, ACS chemical biology, 11(12), 3431-3441. (SCIE)
  • T.-C. Kuo, L.-W. Li, S.-H. Pan, J.-M. Fang, J.-H. Liu, T.-R. Cheng, C.-J. Wang, P.-F. Hung, H.-Y. Chen, T.-M. Hong, Y.-L .Hsu, C.-H. Wong, P.-C. Yan, 2016, “Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin.”, JOURNAL OF MEDICINAL CHEMISTRY, 59(18), 8521-8534. (SCIE)
  • S. K. C. Cheung, P.-K. Chuang, H.-W. Huang, W. W. Hwang-Verslues, C. H.-H. Cho, W.-B. Yang, C.-N. Shen, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-H. Wong, 2016, “Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells.”, Proceedings of the National Academy of Sciences of the United States of America, 113(4), 960-965. (SCIE)
  • C.-H. Hsu, S. Park, D. E. Mortenson, B. L. Foley, X. Wang, R. J. Woods, D. A. Case, E. T. Powers, C.-H. Wong, H. J. Dyson, J. W. Kelly, 2016, “The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate.”, Journal of the American Chemical Society, 138(24), 7636-7648. (SCIE)
  • G. B. E. Stewart-Jones, C. Soto, T. Lemmin, G.-Y. Chuang, A. Druz, R. Kong, P. V. Thomas, K. Wagh, T. Zhou, A.-J. Behrens, T. Bylund, C. W. Choi, J. R. Davison, I. S. Georgiev, M. G. Joyce, Y. D. Kwon, M. Pancera, J. Taft, Y. Yang, B. Zhang, S. S. Shivatare, V. S. Shivatare, C.-C. D. Lee, C.-Y. Wu, C. A. Bewley, D. R. Burton, W. C. Koff, M. Connors, M. Crispin, B. T. Korber, C.-H. Wong, J. R. Mascola and P. D. Kwong, 2016, “Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.”, Cell, 165(4), 813-826. (SCIE)
  • L. Krasnova and C.-H. Wong, 2016, “Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis”, Annual Review of Biochemistry, 85, 599-630. (SCIE)
  • C.-W. Lin, M.-H. Tsai, S.-T. Li, T.-I. Tsai, K.-C. Chu, Y.-C. Liu, M.-Y. Lai, C.-Y. Wu, Y.-C. Tseng, S. S. Shivatare, C.-H. Wang, P. Chao, S.-Y. Wang, H.-W. Shih, Y.-F. Zeng, T.-H. You, J.-Y. Liao, Y.-C. Tu, Y.-S. Lin, H.-Y. Chuang, C.-L. Chen, C.-S. Tsai, C.-C. Huang, N.-H. Lin, C. Ma, C.-Y. Wu, and C.-H. Wong, 2015, “A common glycan structure on immunoglobulin G for enhancement of effector functions”, Proceedings of the National Academy of Sciences of the United States of America, 112(34), 10611-10616. (SCIE)
  • C.-H. Wong, 2015, “Chemistry in Taiwan and Academia Sinica”, Angewandte Chemie-International Edition, 54(46), 13472-13473. (SCIE)
  • X. Li, A. Kawamura, C. Andrews, J. Miller, D. Wu; M. Zhang, J. Huang, D. Oren, N. Padte, S. Porcelli, C.-H. Wong, S. Kappe, D. Ho, M. Tsuji, 2015, “Co-localization of a CD1d-binding glycolipid with malaria vaccines in LN-resident DCs for a robust adjuvant effect”, JOURNAL OF IMMUNOLOGY, 195(6), 2710-2721. (SCIE)
  • S. Danishefsky, Y.-K. Shue, M. Chang, C.-H. Wong, 2015, “Development of Globo-H Cancer Vaccine”, Accounts of Chemical Research, 48(3), 643-652. (SCIE)
  • H.-Y. Yen, Y.-C. Liu, N.-Y. Chen, C.-F. Tsai, Y.-T. Wang, Y.-J. Chen, T.-L. Hsu, P.-C.Yang, C.-H. Wong, 2015, “Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition”, Proceedings of the National Academy of Sciences of the United States of America, 112(22), 6955-6960. (SCIE)
  • T.-W. Lin, H.-T. Chang, C.-H. Chen, C.-H. Chen, S.-W. Lin, T.-L. Hsu, C.-H. Wong, 2015, “Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis”, Journal of the American Chemical Society, 137(30), 9685-9693. (SCIE)
  • J.-T. Chen, K.-L. Ku, C.-H. Chen, M. Hsiao, C.-P. Chiang, T.-L. Hsu, M.-H. Chen, and C.-H. Wong, 2015, “Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response”, Proceedings of the National Academy of Sciences of the United States of America, 112(42), 13057-13062. (SCIE)
  • Y.-L. Huang, F.-S. Pai, Y.-T. Tsou, H.-C. Mon, T.-L. Hsu, C.-Y. Wu, T.-Y. Chou, W.-B. Yang, C.-H. Chen, C.-H. Wong, S.-L. Hsieh, 2015, “Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity”, The Journal of biological chemistry, 290(35), 21252-21263. (SCIE)
  • Y.-Y. Ke, C.-H. Tsai, H.-M. Yu, Y.-C. Jao, J.-M. Fang, C.-H. Wong, 2015, “Latifolicinin A from a Fermented Soymilk Product and the Structure-Activity Relationship of Synthetic Analogues as Inhibitors of Breast Cancer Cell Growth”, Journal of agricultural and food chemistry, 63(44), 9715-9721. (SCIE)
  • S. K. C. Cheung, P.-K. Chuang, H.-W. Huang, W. W. Hwang-Verslues, C. H.-H. Cho, W.-B. Yang, C.-N. Shen, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-H. Wong, 2015, “Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells”, Proceedings of the National Academy of Sciences of the United States of America, 113(4), 960-965. (SCIE)
  • C.-C. Tsai, C.-R. Lin, H.-Y. Tsai, C.-J. Chen, W.-T. Li, H.-M. Yu, Y.-Y. Ke, W.-Y. Hsieh, C.-Y. Chang, Y.-T. Wu, S.-T. Chen, C.-H. Wong, 2015, “The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling”, The Journal of biological chemistry, 290(19), 11935. (SCIE)
  • J -R. Huang , Y.-C. Tsia , Y.-J. Chang , J.-C. Wu , J.-T. Hung , K.-H. Lin , C.-H. Wong and Alice L. Yu, 2014, “alpha-Galactosylceramide but Not Phenyl-Glycolipids Induced NKT Cell Anergy and IL-33-Mediated Myeloid-Derived Suppressor Cell Accumulation via Upregulation of egr2/3.”, Journal of immunology, 192(4), 1972-1981. (SCIE)
  • J.-J. Shie, Y.-C. Liu, Y.−M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, 2014, “An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation”, Journal of the American Chemical Society, 136(28), 9953-9961. (SCIE)
  • Chung-Yi Wu, Chi-Huey Wong, 2014, “Automated programmable one-pot synthesis of glycans”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 45-52, Japan: Springer Japan.
  • Chung-Yi Wu, Chi-Huey Wong, 2014, “Automation in glycan synthesis”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 345-351, Japan: Springer Japan.
  • E. Falkowska, A. Ramos, K. J. Doores, J. H. Lee, C. Blattner, A. Ramirez, R. Derking, M. J. van Gils, C.-H. Liang, R. Mcbride, S. S. Shivatare, C.-Y. Wu, P.-Y. Chan-Hui, Y. Liu, T. Feizi, M. B. Zwick, W. C. Koff, M. S. Seaman, K. Swiderek, J. P. Moore, J. C. Paulson, C.-H. Wong, A. B. Ward, I. A. Wilson, R. W. Sanders, P. Poignard, and D. R. Burton, 2014, “Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers.”, Immunity, 40(5), 657-668. (SCIE)
  • A.-K. Sauer, C.-H. Liang, J. Stech, B. Peeters, P. Quéré, C. Schwegmann-Wessels, C.-Y. Wu, C.-H. Wong, G. Herrler , 2014, “Characterization of the sialic Acid binding activity of influenza a viruses using soluble variants of the h7 and h9 hemagglutinins.”, PloS one, 9(2), e89529. (SCIE)
  • J.-M. Fang, Y.-S. Chen, H.-M. Yu, J.-J. Shie, T.-J. R. Cheng, C.-Y. Wu, C.-H. Wong, 2014, “Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity.”, Bioorganic & medicinal chemistry, 22(5), 1766-1772. (SCIE)
  • Chi-Huey Wong, 2014, “Chemo-enzymatic Synthesis of Glycans: Overview”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 293-294, Japan: Springer Japan.
  • Chi-Huey Wong and Naoyuki Taniguchi, 2014, “Current Status and New Challenges”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 11-14, Japan: Springer Japan.
  • Y.-Y. Tseng, J.-M. Liou, T.-L. Hsu, W.-C. Cheng, M.-S. Wu, C.-H. Wong, 2014, “Development of bacterial transglycosylase inhibitors as new antibiotics: Moenomycin A treatment for drug-resistant Helicobacter pylori.”, Bioorganic & medicinal chemistry letters, 24(11), 2412-2414. (SCIE)
  • L.-Y. Huang, S.-H. Huang, Y.-C. Chang, W.-C. Cheng, T.-J. R. Cheng, and C.-H. Wong, 2014, “Enzymatic Synthesis of Lipid II and Analogues.”, Angewandte Chemie-International Edition, 53(31), 8060-8065. (SCIE)
  • S.-C. Lin, W.-C. Liu, J.-T. Jan, C.-H. Wong, S.-C. Wu, 2014, “Glycan Masking of Hemagglutinin for Adenovirus Vector and Recombinant Protein Immunizations Elicits Broadly Neutralizing Antibodies against H5N1 Avian Influenza Viruses”, PLoS One, 9(3), e92822. (SCIE)
  • Chi-Huey Wong, 2014, “Homogeneous Glycoproteins: Overview”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 959-962, Japan: Springer Japan.
  • Chung-Yi Wu, Chi-Huey Wong, 2014, “Imaging by Click Chemistry”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 459-465, Japan: Springer Japan.
  • C.-H. Hsu, M. Schelwies, S. Enck, L.-Y. Huang, S.-H. Huang, Y.-F. Chang, T.-J. Cheng, W.-C. Cheng, C.-H. Wong, 2014, “Iminosugar C-Glycoside Analogues of alpha-d-GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase Inhibition.”, The Journal of organic chemistry, 79(18), 8629-8637. (SCIE)
  • H.-Y. Lee, C.-Y. Chen, T.-I. Tsai, S.-T. Li, K.-H. Lin, Y.-Y. Cheng, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, 2014, “Immunogenicity study of Globo H derivatives with modification at the reducing or non-reducing end of the tumor antigen”, J. Am. Chem. Soc., 136(48), 16844-16853. (SCIE)
  • Tsung-I Tsai, Chung-Yi Wu, Chi-Huey Wong, 2014, “Large-scale enzymatic synthesis of glycans with cofactor regeneration”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 409-417, Japan: Springer Japan.
  • Chi-Huey Wong, 2014, “Molecular Probes for Glycosylation: Overview”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 455-457, Japan: Springer Japan.
  • C.-S. Chu, P.-W. Lo, Y.-H. Yeh, P.-H. Hsu, S.-H. Peng, Y.-C. Teng, M.-L. Kang, C.-H. Wong and L.-J. Juan, 2014, “O-GlcNAcylation regulates EZH2 protein stability and function.”, Proceedings of the National Academy of Sciences of the United States of America, 111(4), 1355-1360. (SCIE)
  • B.-T. Hong, C.-L. Chen, Jim-Min Fang, Shi-Yun Wang, Wen-I Huang, Yih-Shyun E. Cheng, and Chi-Huey Wong, 2014, “Oseltamivir Hydroxamate and Acyl Sulfonamide Derivatives as Influenza Neuraminidase Inhibitors”, BIOORGANIC & MEDICINAL CHEMISTRY, 22(23), 6647-6654. (SCIE)
  • J.-T. Hung, Y.-C. Tsai, W.-D. Lin, J.-T. Jan, K.-H. Lin, J.-R. Huang, J.-Y. Cheng, M.-W. Chen, C.-H. Wong, and A. L. Yu, 2014, “Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus.”, Antiviral research, 107, 110-118. (SCIE)
  • Chung-Yi Wu, Chi-Huey Wong, 2014, “Preparation of glycan array and its applications”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 35-43, Japan: Springer Japan.
  • P.-C. Chen, P.-K. Chuang, C.-H. Chen, J.-R. Chen, S.-W. Lin, C. Ma, T.-L. Hsu, C.-H. Wong, 2014, “Role of N-linked glycans in the interactions of recombinant HCV envelope glycoproteins with cellular receptors.”, ACS chemical biology, 9(7), 1437-1443. (SCIE)
  • C.-Y. Wang, C.-Y. Wu, T.-J. Hung, C.-H. Wong, C.-H. Chen, 2014, “Sequence-constructive SELEX: A new strategy for screening DNA aptamer binding to Globo H.”, Biochemical and biophysical research communications, 452(3), 484-489. (SCIE)
  • Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang, S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2014, “Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers”, Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2482-2487. (SCIE)
  • C.-L. Chen, T.-C. Lin, S.-Y. Wang, J.-J. Shie, K.-C. Tsai, Y.-S. E. Cheng, J.-T. Jan, C.-J. Lin, J.-M. Fang, and C.-H. Wong, 2014, “Tamiphosphor Monoesters as Effective Anti-influenza Agents”, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 81, 106-118. (SCIE)
  • J. Lin, Y.-J. Chang, W.-B. Yang, A. L. Yu, and C.-H. Wong, 2014, “The Multifaceted Effects of Polysaccharides Isolated from Dendrobium huoshanense on Immune Functions with the Induction of Interleukin-1 Receptor Antagonist (IL-1ra) in Monocytes.”, PloS one, 9(4), e94040. (SCIE)
  • J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu, S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma and C.-H. Wong, 2014, “Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections”, Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2476-2481. (SCIE)
  • Chung-Yi Wu, Chi-Huey Wong, 2014, “Vaccines”, editor(s): N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger, C.-H.Wong, Glycoscience: Biology and Medicine, pp. 1529-1508, Japan: Springer Japan.
  • K. J. Doores, M. Huber, K. M. Le, S.-K. Wang, C. Doyle-Cooper, A. Cooper, R. Pantophlet, C.-H. Wong, D. Nemazee, D. R. Burton, 2013, “2G12-expressing B cell lines inform HIV carbohydrate vaccine design strategies”, Journal of Virology, 87(4),2234-2241. (SCIE)
  • E. Al-Shareffi, J.-L. Chaubard, C. Leonhard-Melief, C.-H. Wong, and R. S. Haltiwanger,, 2013, “6-Alkynyl Fucose is a bioorthogonal analogue for O-fucosylation of Epidermal Growth Factor-like repeats and Thrombospondin Type-1 repeats by Protein O-Fucosyltransferases 1 and 2.”, Glycobiology, 23(2), 188-198. (SCIE)
  • C.-S. Tsai, H.-Y. Yen, M.-I. Lin, T.-I. Tsai, S.-Y. Wang, W.-I. Huang, T.-L. Hsu, Y.-S. E. Cheng, J.-M. Fang, C.-H. Wong, 2013, “A Cell Permeable Probe for Identification and Imaging of Sialidases”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2466-2471. (SCIE)
  • N. Padte, M. B. Carrera, C. A. McManus, B. Grasperge, A. Gettie, J. Coelho-dos-Reis, X. Li, N. Levenkova, D. Wu, J. T. Bruder, M. Sedegah, N. Petterson, T. Richie, C.-H. Wong, D. D. Ho, S. Vasan, M. Tsuji, 2013, “A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates.”, PloS one, 8(10), e78407. (SCIE)
  • H.-W. Huang, C.-H. Chen, C.-H. Lin, C.-H. Wong, K.-I. Lin, 2013, “B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention.”, Proceedings of the National Academy of Sciences of the United States of America, 110(27), 10928-10933. (SCIE)
  • Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2517-2522. (SCIE)
  • T.-J. R. Cheng, S.-Y. Wang, W.-H. Wen, C.-Y. Su, M. Lin, W.-I. Huang, M.-T. Liu, H.-S. Wu, N-S. Wang, C.-K. Cheng, C.-L. Chen, C.-T. Ren, C.-Y. Wu, J.-M. Fang, Y.-S. E. Cheng and C.-H. Wong, 2013, “Chemical probes for drug resistance assessment by binding competition (RABC) oseltamivir susceptibility evaluation”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(1), 366-370. (SCIE)
  • C.-Y. Yang, J.-B. Chen, T.-F. Tsai, Y.-C. Tsai, C.-Y. Tsai, P.-H. Liang, T.-L. Hsu, C.-Y. Wu, M. G. Netea, C.-H. Wong, S.-L. Hsieh, 2013, “CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver.”, PloS one, 8(6), e65070. (SCIE)
  • S.-C. Lin, J.-T. Jan, B. Dionne, M. Butler, M.-H. Huang, C.-Y. Wu, C.-H. Wong, S.-C. Wu, 2013, “Different Immunity Elicited by Recombinant H5N1 Hemagglutinin Proteins Containing Pauci-Mannose, High-Mannose, or Complex Type N-Glycans.”, PloS one, 8(6), e66719. (SCIE)
  • T.-I. Tsai, H.-Y. Lee, S.-H. Chang, C.-H. Wang, Y.-C. Tu, Y.-C. Lin, D.-R. Hwang, C.-Y. Wu, C.-H. Wong, 2013, “Effective sugar nucleotide regeneration for the large-scale enzymatic synthesis of Globo H and SSEA4.”, Journal of the American Chemical Society, 135(39), 14831-14839. (SCIE)
  • S. Shivatare, S.-H.Chang, T.-I. Tsai, C.-T. Ren, H.-Y. Chuang, L. Hsu, C.-W. Lin, S.-T. Li, C.-Y. Wu, C.-H. Wong, 2013, “Efficient Convergent Synthesis of Bi-, Tri-, and Tetra-antennary Complex Type N-Glycans and Their HIV-1 Antigenicity.”, Journal of the American Chemical Society, 135(41), 15382-15391. (SCIE)
  • C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2013, “Fucosyltransferase 8 as a Functional Regulator of Non-Small Cell Lung Cancer”, Proceedings of the National Academy of Sciences of the United States of America, 110(2), 630-635. (SCIE)
  • S.-F. Liao, C.-H. Liang, M.-Y. Ho, T.-L. Hsu,T.-I. Tsai, Y. S.-Y. Hsieh, S.-T. Li, Y.-Y. Cheng, S.-M. Tsao,T.-Y. Lin, Z.-Y. Lin,W.-B. Yang,C.-T. Ren, K.-I. Lin, K.-K. Khoo, C.-H. Lin, H.-Y. Hsu,C.-Y. Wu, C.-H. Wong, 2013, “Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies against tumor-associated Globo H-series epitopes”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110, 13809-13814. (SCIE)
  • T.-C. Hung, C.-W. Lin, T.-L. Hsu, C.-Y. Wu, C.-H. Wong, 2013, “Investigation of SSEA-4 binding protein in breast cancer cells.”, Journal of the American Chemical Society, 135(16), 5934-5937. (SCIE)
  • R. Bryk, N. Arango, C. Maksymiuk, A. Balakrishnan, Y.-T. Wu, C.-H. Wong, T. Masquelin, P. Hipskind, C. D. Lima, and C. Nathan, 2013, “Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase”, BIOCHEMISTRY, 52(51), 9375-9384. (SCIE)
  • S.-H. Huang, W.-S. Wu, L.-Y., Huang, W.-F., Huang, W.-C., Fu,; S.-T. Yang, P.-T. Chen, J.-M. Fang, W.-C. Cheng, T.-J. Cheng, C.-H. Wong, 2013, “New continuous fluorometric assay for bacterial transglycosylase using forster resonance energy transfer.”, Journal of the American Chemical Society, 135(45), 17078-17089. (SCIE)
  • K.-T. Chen, Y.-C. Kuan, W.-C. Fu, H.-W. Shih, P.-H. Liang, T.-J. R. Cheng, C.-H. Wong, and W.-C. Cheng, 2013, “Rapid Preparation of Mycobacterium N-Glycolyl Lipid I and Lipid II Derivatives via a Biocatalytic Approach”, Chemistry a European Journal, 19(3), 834-838. (SCIE)
  • W. Chen, S. Enck, J. Price, D. Powers, E. Powers, C.-H. Wong, H. J. Dyson, J. Kelly, 2013, “Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins.”, Journal of the American Chemical Society, 135(26), 9877-9884. (SCIE)
  • K. Ohara, C.-C. Lin, P.-J. Yang, W.-T. Hung, W.-B. Yang, T.-J. Cheng, J.-M. Fang, C.-H. Wong, 2013, “Synthesis and Bioactivity of beta-(1-->4)-Linked Oligomannoses and Partially Acetylated Derivatives.”, The Journal of organic chemistry, 78(13), 6390-6411. (SCIE)
  • H.-Y.Chuang, C.-T. Ren, C.-A. Chao, C.-Y. Wu, S. Shivatare; T.-J. R. Cheng, C.-Y. Wu, C.-H. Wong, 2013, “Synthesis and Vaccine Evaluation of the Tumor-Associated Carbohydrate Antigen RM2 from Prostate Cancer.”, Journal of the American Chemical Society, 135(30), 11140-11150. (SCIE)
  • C.-H. Wang, S.-T. Li, T.-L. Lin, Y.-Y. Cheng, T.-H. Sun, J.-T. Wang, T.-J. Cheng, K.-K. Mong, C.-H. Wong, C.-Y. Wu, 2013, “Synthesis of Neisseria meningitidis Serogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development.”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(35), 9157-9161. (SCIE)
  • C.-C.Tsai, C.-R. Lin, H.-Y. Tsai, C.-J. Chen, W.-T. Li, H.-M.Yu, Y.-Y. Ke, W.-Y. Hsieh, C.-Y. Chang, C.-Y. Wu, S.-T. Chen, C.-H. Wong, 2013, “The Immunologically Active Oligosaccharides Isolated from Wheatgrass Modulate Monocytes via Toll-like Receptor-2 Signaling.”, The Journal of biological chemistry, 288(24), 17689-17697. (SCIE)
  • T.-L. Hsu, G. Lin, A. Koizumi, K. Brehm, N. Hada, P.-K.Chuang, C.-H. Wong, S.-L. Hsieh, A. Diaz, 2013, “The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor.”, Molecular and biochemical parasitology, 192(1-2), 55-9. (SCIE)
  • Y. Hsu, X.-A. Lu, M. Zulueta, C.-M. Tsai, K.-I. Lin, S.-C. Hung, C.-H. Wong, 2012, “Acyl and Silyl Group Effects in Reactivity-based One-pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4 ”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(10), 4549-4552. (SCIE)
  • C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong and C. Ma, 2012, “Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis”, Proceedings of the National Academy of Sciences of the United States of America, 109(17), 6496-6501. (SCIE)
  • T.-J. R. Cheng, S. Weinheimer, E. B. Tarbet, J.-T. Jan, Y.-S. E. Cheng, J.-J. Shie, C.-L. Chen, C.-A. Chen, W.-C. Hsieh, P.-W. Huang, W.-H. Lin, S.-Y. Wang, J.-M. Fang, O. Y.-P. Hu, and C.-H. Wong, 2012, “Development of Oseltamivir Phosphonate Congeners as Anti-influenza Agents.”, Journal of medicinal chemistry, 55(20), 8657-8670. (SCIE)
  • H.-W. Shih, Y.-F. Chang, W.-J. Li, F.-C. Meng, C.-Y. Huang, C. Ma, T.-J. R. Cheng, C.-H. Wong, W.-C. Cheng, 2012, “Effect of the peptide moiety of lipid II on bacterial transglycosylase”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(40), 10123-10126. (SCIE)
  • S.-H. Chen, D.-R. Hwang, G.-H. Chen, N.-S. Hsu, Y.-T. Wu, T.-L. Li, C.-H. Wong, 2012, “Engineering Transaldolase in Pichia stipitis to Improve Bioethanol Production”, ACS CHEMICAL BIOLOGY, 7(3), 481-486. (SCIE)
  • K.-C. Liu, J.-M. Fang, J.-T. Jan, T.-J. R. Cheng, S.-Y. Wang, Y.-S. E. Cheng, K.-C. Tsai, A.-S. Yang, and C.-H. Wong, 2012, “Enhanced Anti-influenza Agents Conjugated with Anti-inflammatory Activity.”, Journal of medicinal chemistry, 55(19), 8493-8501. (SCIE)
  • J. Lenger, M. Schröder, E. C. Ennemann, B. Müller, C.-H. Wong, T. Noll, T. Dierks, S. R. Hanson, N. Sewald, 2012, “Evaluation of Sulfatase-Directed Quinone Methide Traps for Proteomics”, BIOORGANIC & MEDICINAL CHEMISTRY, 20(2), 622-627. (SCIE)
  • J. L. Price, E. K. Culyba, W. Chen, A. N. Murray, S. R. Hanson, C.-H. Wong, E. T. Powers, J. W. Kelly, 2012, “N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability.”, Biopolymers, 98(3), 195-211. (SCIE)
  • M.-H. Hsieh, J.-T. Hung, Y.-W. Liw, Y.-J. Lu, C.-H. Wong, A. L. Yu, and P.-H. Liang, 2012, “Synthesis and evaluation of acyl-chain- and galactose-6''-modified analogues of alpha-GalCer for NKT cell activation.”, Chembiochem, 13(11), 1689-1697. (SCIE)
  • S.-C. Hung, M. Zulueta, S.-Y. Lin, Y.-T. Lin, C.-J. Huang, C.-C. Wang, C.-C. Ku, Z.-H. Shi, C.-L. Chyan, D. Irene, L.-H. Lim, T.-I. Tsai, Y.-P. Hu, S. Arco, C.-H. Wong, 2012, “α-Glycosylation by D-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogs that Interact with Mycobacterial Heparin-Binding Hemagglutinin”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134 (21), 8988-8995. (SCIE)
  • L. M. Walker, M. Huber, K. J. Doores, E. Falkowska, R. Pejchal, J.-P. Julien, S.-K. Wang, P.-Y. Chan-Hui, P. W. Hammond, O. A. Olsen, A. Ramos, P. Phung, T. Wrin, M. D. Simek, S. Fling, C.-H. Wong, S. Phogat, W. C. Koff, I. A. Wilson, D. R. Burton, P. Poignard, 2011, “Broad neutralization coverage of HIV by multiple highly potent antibodies”, NATURE, 477(7365), 466-470. (SCIE)
  • K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, T.-A. Chao, Y.-F. Lin, S.-H. Wu, C.-H. Wong and C.-Y. Wu, 2011, “Efficient and Stereoselective Synthesis of α(2→9) Oligosialic Acids Up to Dodecamer”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(40), 9391-9395. (SCIE)
  • H.-L. Yen, C.-H. Liang, C.-Y. Wu, H. Forrest, A. Ferguson, K.T. Choy, J. Jones, D.D.Y. Wong, P.P.H. Cheung, C.-H. Hsu, O.T. Li, K.M. Yuen, R.W.Y. Chan, L.L.M. Poon, M.C.W. Chan, J. Nicholls, S. Krauss, C.-H. Wong, Y. Guan, R.G. Webster, R.J. Webby & J.S.M. Peiris, 2011, “Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(34), 14264-14269. (SCIE)
  • K.-C. Liu, P.-S. Lee, S.-Y. Wang, Y.-S. E. Cheng, J.-M. Fang and C.-H. Wong, 2011, “Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir”, BIOORGANIC & MEDICINAL CHEMISTRY, 19(16), 4796-4802. (SCIE)
  • R. Schmaltz, S. R. Hanson, C.-H. Wong, 2011, “Enzymes in the Synthesis of Glycoconjugates”, CHEMICAL REVIEWS, 111(7), 4259-4307. (SCIE)
  • Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, 2011, “Sialylation and Fucosylation of Epidermal Growth Factor Receptor Suppress its Dimerization and Activation in Lung Cancer Cells”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(28), 11332-11337. (SCIE)
  • J.-R. Chen, C. Ma and C.-H. Wong, 2011, “Vaccine design of hemagglutinin glycoprotein against influenza”, TRENDS IN BIOTECHNOLOGY, 29(9), 426-434. (SCIE)
  • B.-L. Tsai, J.-L. Han, C.-T. Ren, C.-Y. Wu and C.-H. Wong, 2011, “Programmable One-Pot Synthesis of Tumor-Associated Carbohydrate Antigens Lewis X Dimer and KH-1 Epitopes”, TETRAHEDRON LETTERS, 52(17), 2132-2135. (SCIE)
  • H.-W. Shih, K.-T. Chen, T.-J. Cheng, C.-H. Wong, W.-C. Cheng, 2011, “A New Synthetic Approach toward Bacterial Transglycosylase Substrates, Lipid II and Lipid IV”, ORGANIC LETTERS, 13(17), 4600-4603. (SCIE)
  • R. Pejchal, K.J. Doores, L.M. Walker, R. Khayat, P.-S. Huang, S.-K. Wang, R.L. Stanfield, J.P. Julien, A. Ramos, M. Crispin, R. Depetris, U. Katpally, A. Marozsan, A. Cupo, S. Maloveste, Y. Liu, R. McBride, Y. Ito, R.W. Sanders, C. Ogohara, J.C. Paulson, T. Feizi, C.N. Scanlan, C.-H. Wong, J.P. Moore, W.C. Olson, A.B. Ward, P. Poignard, W.R. Schief, D.R. Burton, I.A. Wilson, 2011, “A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield”, SCIENCE, 334(6059), 1097-1103. (SCIE)
  • J.-J. Shie, J.-M. Fang, P.-T. Lai, W.-H. Wen, S.-Y. Wang, Y.-S. Cheng, K.-C. Tsai, A.-S. Yang, C.-H. Wong, 2011, “A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-influenza Activity”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(44), 17959-17965. (SCIE)
  • T.-N. Wu, K.-H. Lin, Y.-J. Chang, J.-R. Huang, J.-Y. Cheng, A. L. Yu, and C.-H. Wong, 2011, “Avidity of CD1d-ligand-receptor ternary complex contributes to Th1 polarization and anticancer efficacy”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(42), 17275-17280. (SCIE)
  • M. W. Chen, H.-Y. Liao, T.-J. R. Cheng, C.-T. Ren, C.-Y. Wu, Y. Huang, D. D. Ho, C.-H. Wong, 2011, “Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(9), 3510-3515. (SCIE)
  • C.-Y. Wu and C.-H. Wong, 2011, “Chemistry and glycobiology”, CHEMICAL COMMUNICATIONS, 47(22), 6201-6207. (SCIE)
  • Y.-F. Shen, Y.-H. Chen, S.-Y. Chu, M.-I. Lin, H.-T. Hsu, P.-Y. Wu, C.-J. Wu, H.-W. Liu, F.-Y. Lin, G. Lin, P.-H. Hsu, A.-S. Yang, Y.-S. E. Cheng, Y.-T. Wu, C.-H. Wong, and M.-D. Tsai, 2011, “E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors”, Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16515-16520. (SCIE)
  • C.-H. Liang, S.-K. Wang, C.-W. Lin, C.-C. Wang, C.-H. Wong, C.-Y. Wu, 2011, “Effects of neighboring glycans on antibody-carbohydrate interaction”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(7), 1608-1612. (SCIE)
  • J.-W. Hsu, H.-C. Huang, S.-T. Chen, C.-H. Wong, H.-F. Juan, 2011, “Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation”, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 1-13. (SCIE)
  • D. Punyadarsaniya, C.-H. Liang, C. Winter, H. Petersen, S. Rautenschlein, I. Hennig-Pauka, C. Schwegmann-Wessels, C.-Y. Wu, C.-H. Wong, G. Herrler, 2011, “Infection of differentiated porcine airway epithelial cells by influenza virus: differential susceptibility to infection by porcine and avian viruses”, PLoS One, 6(12), e28429. (SCIE)
  • Y. Kinjo, P. Illarionov, J. L. Vela, B. Pei, E. Girardi, X. Li, Y. Li, M. Imamura, Y. Kaneko, Y. Miyazaki, P. Rogers, S. Dahesh, S. Uchiyama, A. Khurana, K. Kawahara, H. Yesilkaya, P. W. Andrew, C.-H. Wong, K. Kawakami, V. Nizet, G. S. Besra, M. Tsuji, D. M. Zajonc, M. Kronenberg, 2011, “Invariant NKT cells recognize glycolipids from pathogenic Gram-positive bacteria”, NATURE IMMUNOLOGY, 12(10), 966-974. (SCIE)
  • C.-Y. Chou, T.-P. Ko, K.-J. Wu, K.-F. Huang, C.-H. Lin, C.-H. Wong, A. H.-J. Wang, 2011, “Modulation of Substrate Specificities of D-Sialic Acid Aldolase through Single Mutations of Val-251.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(16), 14057-14064. (SCIE)
  • C.-Y. Wu and C.-H. Wong, 2011, “Programmable one-pot glycosylation”, Topics in Current Chemistry, 301, 223-252. (SCIE)
  • E. K. Culyba, J. L. Price, S. R. Hanson, A. Dhar, C.‐H. Wong, M. Gruebele, E. T. Powers and J. W. Kelly, 2011, “Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns”, Science, 331(6017), 571-575. (SCIE)
  • C.-F. Chang, J.-F. Pan, C.-N. Lin, C.-H. Wong, C.-H. Lin, 2011, “Rapid Characterization of Sugar-Binding Specificity by In-Solution Proximity Binding with Photosensitizers”, GLYCOBIOLOGY, 21(7), 895-902. (SCIE)
  • R. T. Lee, T.-L. Hsu, S. K. Huang, S.-L. Hsieh, C.-H. Wong, and Y. C. Lee, 2011, “Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities”, GLYCOBIOLOGY, 21(4), 512-520. (SCIE)
  • F.-C. Meng, K.-T. Chen, L.-Y. Huang, H.-W. Shih, H.-H. Chang, F.-Y. Nien, P.-H. Liang, T.-J. Cheng, C.-H. Wong, W.-C. Cheng, 2011, “Total Synthesis of Polyprenyl N-Glycolyl Lipid II as a Mycobacterial Transglycosylase Substrate”, ORGANIC LETTERS, 13(19), 5306-5309. (SCIE)
  • C.-H. Hsu, S.-C. Hung, C.-Y. Wu, and C.-H. Wong, 2011, “Toward Automated Oligosaccharide Synthesis”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(50), 11872-11923. (SCIE)
  • M. Schelwies, D. Brinson, Y.-H. Hong, M. K. Lotz, C.-H. Wong, and S. R. Hanson, 2010, “GlcN-6-sulfamate Heparan Analogs as Inhibitors of Endosulfatases”, ChemBioChem, 11(17), 2393-2397. (SCIE)
  • C.-S. Tsai, P.-Y. Liu, H.-Y. Yen, T.-L. Hsu, C.-H. Wong, 2010, “Development of trifunctional probes for glycoproteomic analysis.”, CHEMICAL COMMUNICATIONS, 46(30), 5575-5577. (SCIE)
  • S. Otsuki, S. Hanson, S. Miyaki, S. Grogan, M. Kinoshita, H. Asahara, C.-H. Wong , M. Lotz, 2010, “Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.”, Proceedings of the National Academy of Sciences of the United States of America, 107(22), 10202-10207. (SCIE)
  • C.-C. Chang, A. F. Ku, Y.-Y. Tseng, W.-B. Yang, J.-M. Fang, and C.-H. Wong, 2010, “6,8-Di-C-glycosyl flavonoids from Dendrobium huoshanense.”, Journal of natural products, 73(2), 229-232. (SCIE)
  • R. J. Payne and C.-H. Wong, 2010, “Advances in Chemical Ligation Strategies for the Synthesis of Glycopeptides and Glycoproteins”, CHEMICAL COMMUNICATIONS, 46, 21-43. (SCIE)
  • W.-H. Wen, S.-Y. Wang, K.-C. Ysai, Y.-S. E. Cheng, A.-S. Yang, J.-M. Fang, C.-H. Wong, 2010, “Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses.”, Bioorganic & medicinal chemistry, 18(11), 4074-4084. (SCIE)
  • J. C. Lewis, S. M. Mantovani, Y. Fu, C. D. Snow, R. S. Komor, C.-H. Wong, F. H. Arnold, 2010, “Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates”, CHEMBIOCHEM, 11(18), 2502-2505. (SCIE)
  • H.-W. Shih, K.-T. Chen, S.-K. Chen, C.-Y. Huang, T.-J. Cheng, C. Ma, C.-H. Wong, W.-C. Cheng, 2010, “Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors.”, Organic & biomolecular chemistry, 8(11), 2586-2593. (SCIE)
  • R. D. Astronomo, E. Kaltgrad, A. K. Udit, S.-K. Wang, R. Pantophlet, C.-Y. Huang, J. C. Paulson, C.-H. Wong, M.G. Finn and D. R. Burton, 2010, “Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds.”, Chemistry & biology, 17(4), 357-370.
  • X. Li, D. Wu, M. Fujio, M. Imamura, S. Vasan, C.-H. Wong, D. D. Ho, M. Tsuji, 2010, “Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant.”, Proceedings of the National Academy of Sciences of the United States of America, 107(29), 13010-13015. (SCIE)
  • H.-Y. Liao, C.-H. Hsu, S.-C. Wang, C.-H. Liang, H.-Y. Yen, C.-Y. Su, J.-T. Jan, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, 2010, “Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays”, J. Am. Chem. Soc., 132(42),14849-14856. (SCIE)
  • W.-Y. Chen, W.-B. Yang, C.-H. Wong, D.T.-B. Shih, 2010, “Effect of Reishi Polysaccharides on Human Stem/Progenitor Cells”, BIOORGANIC & MEDICINAL CHEMISTRY, 18(24), 8583-8591. (SCIE)
  • S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides Through Phosphonate Chemistry”, Journal of the American Chemical Society, 132(38),13371-13380. (SCIE)
  • T.-J. R. Cheng, Y.-T. Wu, S.-T. Yang, A. Loh, S.-K. Chen, Y.-H. Chen, W.-I. Huang, C.-H. Yuan, H.-W. Shih, Y.-S. E. Cheng, W.-C. Cheng, C.-H. Wong, 2010, “High-Throughput Identification of Antibacterials against Methichillin-Resistant Staphylococcus Aureus (MRSA) and the Transglycosylase”, BIOORGANIC & MEDICINAL CHEMISTRY, 18(24), 8512-8529. (SCIE)
  • C.-Y. Su, T.-J. R. Cheng, M.-I. Lin, S.-Y. Wang, W.-I. Huang, S.-Y. Lin-Chua, Y.-H. Chen, C.-Y. Wu, M. M. C. Lai, W.-C. Cheng, Y.-T. Wu, M.-D. Tsai, Y.-S. E. Cheng, C.-H. Wong, 2010, “High-throughput Identification of Compounds Targeting Influenza RNA-dependent RNA Polymerase Activity”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(45), 19151-1916. (SCIE)
  • C.-H. Hsu, K.-C. Chu, Y.-S. Lin, J.-L. Han, Y.-S. Peng, C.-T. Ren, C.-Y. Wu, C.-H. Wong, 2010, “Highly alpha-selective sialyl phosphate donors for efficient preparation of natural sialosides.”, CHEMISTRY-A EUROPEAN JOURNAL, 16(6), 1754-1760. (SCIE)
  • K.-H. Lin, J.-J. Liang, W.-I. Huang, S.-Y. Lin-Chu, C.-Y. Su, Y.-L. Lee, J.-T. Jan, Y.-L. Lin, Y.-S. E. Cheng, and C.-H. Wong, 2010, “In vivo protection of bacterial and viral infections in murine models using a synthetic new {alpha}-GalCer analog.”, Antimicrobial agents and chemotherapy, 54(10), 4129-4136. (SCIE)
  • W.A. Greenberg, C.-H. Wong, 2010, “One-step Synthesis of L-fructose using Rhamnulose-1-phosphate Aldolase in Borate Buffer”, editor(s): J. Whittall, P. Sutton, From Practical Methods for Biocatalysis and Biotransformations, pp. 203-205, New York, NY: John Wiley & Sons, Inc..
  • J.-J. Shie, C.-A. Chen, C.-C. Lin, A. F. Ku, T.-J. R. Cheng, J.-M. Fang, and C.-H. Wong, 2010, “Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities.”, Organic & biomolecular chemistry, 8(19), 4451-4462. (SCIE)
  • C.-Y. Liu, C.-W. Guo, Y.-F. Chang, J.-T. Wang, H.-W. Shih, Y.-F. Hsu, C.-W. Chen, S.-K. Chen, Y.-C. Wang, T.-J. Cheng, C. Ma, C.-H. Wong, J.-M. Fang, W.-C. Cheng, 2010, “Synthesis and evaluation of a new fluorescent transglycosylase substrate: lipid II-based molecule possessing a dansyl-C20 polyprenyl moiety.”, Organic letters, 12(7), 1608-1611. (SCIE)
  • T.-L. Hsu, S.-C. Cheng, W.-B. Yang, S.-W. Chin, S.-L. Hsieh, C.-H. Wong, 2009, “Profiling Carbohydrate-Receptor Interaction with Recombinant Innate Immunity Receptor-Fc Fusion Proteins”, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(50), 34479-34489. (SCIE)
  • C.-H. Wong and P.G. Wang, 2009, Comprehensive Natural Products II: Chemistry and Biology, Vol. 6: Carbohydrates, Nucleosides and Nucleic Acids, 759 pages, Missouri, USA: Elsevier.
  • L. Motiei, S. Rahimipour, D.A. Thayer, C.-H. Wong, M.R. Ghadiri, 2009, “Antibacterial cyclic D,L-alpha-glycopeptides.”, CHEMICAL COMMUNICATIONS, 7(25), 3693-3695. (SCIE)
  • J. C. Lewis, S. Bastian, C. S. Bennett, Y. Fu, Y. Mitsuda, M. M. Chen, W. A. Greenberg, C.-H. Wong, and F. H. Arnold, 2009, “Chemoenzymatic Elaboration of Monosaccharides Using Engineered Cytochrome P450BM3 Demethylases”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(39), 16550-16555. (SCIE)
  • Z. Hong, L. Liu, M. Sugiyama, Y. Fu, C.-H. Wong, 2009, “Concise synthesis of iminocyclitols via Petasis-type aminocyclization.”, Journal of the American Chemical Society, 131(24), 8352-8653. (SCIE)
  • M.-T. Sung, Y.-T. Lai, C.-Y. Huang, L.-Y. Chou, H.-W. Shih, W.-C. Cheng, C.-H. Wong, C. Ma, 2009, “Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli.”, Proceedings of the National Academy of Sciences of the United States of America, 106(22), 8824-8829. (SCIE)
  • C.-H. Wong, 2009, “Enzymes for Glycoprotein Synthesis”, CHIMIA, 63(6), 318-326. (SCIE)
  • C.-C. Wang, J.-R. Chen, Y.-C. Tseng, C.-H. Hsu, Y.-F. Hung, S.-W. Chen, C.-M. Chen, K.-H. Khoo, T.-J. Cheng, Y.-S. E. Cheng, J.-T. Jan, C.-Y. Wu, C. Ma, and C.-H. Wong, 2009, “Glycans on influenza hemagglutinin affect receptor binding and immune response”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(43), 18137-18142. (SCIE)
  • S.-Y. Wang, C.-Y. Su, M. Lin, S.-Y. Huang, W.-I. Huang, C.-C. Wang, Y.-T. Wu, T.-J. R. Cheng, H.-M. Yu, C.-T. Ren, C.-Y. Wu, C.-H. Wong, Y.-S. E. Cheng, 2009, “HA-pseudotyped retroviral vectors for influenza antagonist screening.”, Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening, 14(3), 294-302.
  • C.-H. Liang, C.-C. Wang, Y.-C. Lin, C.-H. Chen, C.-H. Wong, C.-Y. Wu, 2009, “Iron Oxide/Gold Core/Shell Nanoparticles for Ultrasensitive Detection of Carbohydrate-Protein Interactions”, ANALYTICAL BIOCHEMISTRY, 81(18), 7750-7756. (SCIE)
  • C.-Y. Wu, P.-H. Liang and C.-H. Wong, 2009, “New development of glycan arrays”, ORGANIC & BIOMOLECULAR CHEMISTRY, 7(11), 2247-2254. (SCIE)
  • A. Schiefner, M. Fujio, D. Wu, C.-H. Wong and I. A. Wilson, 2009, “Structural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory Ligands”, JOURNAL OF MOLECULAR BIOLOGY, 394(1), 71-82. (SCIE)
  • W.-H. Wen, M. Lin, C.-Y. Su, S.-Y. Wang, Y.-S. E. Cheng, J.-M. Fang and C.-H. Wong, 2009, “Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus.”, Journal of medicinal chemistry, 52(15), 4903-4910. (SCIE)
  • S. R. Hanson, E. K. Culyba, T. L. Hsu, C.-H. Wong, J. W. Kelly, E. T. Powers, 2009, “The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability”, Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3131-3136. (SCIE)
  • M.-H. Chuang, S.-H. Chiou, C.-H. Huang, W.-B. Yang and C.-H. Wong, 2009, “The lifespan-promoting effect of acetic acid and Reishi polysaccharide”, BIOORGANIC & MEDICINAL CHEMISTRY, 17(22), 7831-7840. (SCIE)
  • J.-J. Shie, J.-M. Fang and C.-H. Wong, 2008, “A Concise and Flexible Synthesis of the Potent Anti-Influenza Agents – Tamiflu and Tamiphosphor”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47(31), 5788-5791. (SCIE)
  • M. W. Chen, T.-J. Cheng, Y. Huang, J.-T. Jan, S.H. Ma, A. Yu, C.-H. Wong and D. Ho, 2008, “A Consensus-Hemagglutinin-Based DNA Vaccine that Protects Mice Against Divergent H5N1 Influenza Viruses”, Proceedings of the national academy of sciences of the united states of america, 105(36), 13538-13543. (SCIE)
  • M. J. Giffin, H. Heaslet, A. Brik, Y.-C. Lin, G. Cauvi, C.-H.Wong, D. E. McRee, J. H. Elder, C. D. Stout, B. E. Torbett, 2008, “A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant”, J. Med. Chem, 51(20), 6263-6270. (SCIE)
  • Giffin MJ, Heaslet H, Brik A, Lin YC, Cauvi G, Wong CH, McRee DE, Elder JH, Stout CD, Torbett BE, 2008, “A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant.”, Journal of medicinal chemistry, 51(20), 6263-6270. (SCIE)
  • R. D. Astronomo, H. K. Lee, C. N. Scanlan, R. Pantophlet, C. Y. Huang, I. A. Wilson, O. Blixt, R. A. Dwek, C.-H. Wong and D. R. Burton, 2008, “A glycoconjugate antigen based on the recognition motif of a broadly-neutralising human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120”, JOURNAL OF VIROLOGY, 82, 6359-6368. (SCIE)
  • T. R. Northen, J.-C. Lee, L. Hoang, J. Raymond, D.-R. Hwang, S.M. Yannone, C.-H. Wong and G. Siuzdak, 2008, “A Nanostructure-Initiator Mass Spectrometry Based Enzyme Activity Assay”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(10), 3678-3683. (SCIE)
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