語言

Li, Tsung-Lin

TLLi 6x7Professor
Deputy Director

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+886-2-27871235
[ CV ]

 

 

EDUCATION AND POSITIONS HELD:

  • Ph.D., Chemistry, University of Cambridge (UK), 2004
  • Specialist, National Quarantine Service, Department of Health, Executive Yuan, Taipei, Taiwan, 1991.6-1991.12
  • Specialist, Chemistry Division, National Laboratories of Foods & Drugs, Department of Health, Executive Yuan, Taipei, Taiwan, 1991-1995
  • Teaching assistant, Food Science & Technology, The Ohio State University, 1995-1997
  • Specialist, Microbiology Division, National Laboratories of Foods and Drugs, Department of Health, Executive Yuan, Taipei, Taiwan, 1998-2000
  • Associate Research Scientist, University of Cambridge, 2003-2004
  • Postdoctoral Fellow, Genomics Research Center, 2004-2004
  • Assistant Professor, Biotechnology, Food Science, National Taiwan Ocean University, 2004-2007
  • Assistant Professor, Genomics Research Center, Academia Sinica, 2007-2011
  • Adjunct Assistant/Associate/Professor, Biotechnology Center, National Chung Hsing University, 2009-present
  • Adjunct Assistant/Associate/Professor, Marine Biotechnology Center, National Sun Yat-sen University, 2010-present
  • Associate Professor, Genomics Research Center, Academia Sinica, 2011-2019
  • Professor, Genomics Research Center, Academia Sinica, 2019-present 
  • Deputy Director, Genomics Research Center, Academia Sinica, 2019-present

HONORS:

  • Investigator Award (Academia Sinica), 2020-2024
  • Career Development Award (Academia Sinica), 2014-2018
  • Career Development Award (National Health Research Institutes), 2012-2015
  • Academia Sinica Significant Research, 2018
  • Academia Sinica Significant Research, 2014
  • Academia Sinica Significant Research, 2011
  • Academia Sinica Major Discovery, 2007
  • Overseas PhD Fellowship (in Chemistry, Ministry of Education, MOE), 1998
  • National Certificate in Hygiene Analysis, Advanced National Senior Civil Service Examination (Examination Yuan), 1998
  • Researcher Award, National Annual Research Award (Executive Yuan), 1997
  • Researcher Award, Annual Research Award (Department of Health), 1996
  • National Certificate in Environmental Hygiene, National Senior Civil Service Examination (Examination Yuan), 1991
  • National Certificate in Dietician Profession (Department of Health), 1991
  • National Certificate in Nutrition, Professionals and Technologists Examination (Examination Yuan), 1991

RESEARCH INTERESTS:

Natural product chemistry

Research in the Li lab encompasses a broad spectrum of natural product chemistry in particular in the scopes of elucidation and manipulation of biosynthetic pathways to vital natural products. Natural product chemistry had its genesis in the study of naturally occurring substances, and this remains intellectual challenge and certainly a constant source of information. Current targets include glycopeptides (mannopeptimycin, enduracidine, A40926, teicoplanin, chloroeremomycin), aminoglycosides (moenomycin, minosaminomycin), and marine toxin (tetrodotoxin).

Microbial pathogenicity

The lab is also involved in a multidisciplinary study for characterizing mechanisms of microbial pathogenicity. The current targeted microbe is Klebsiella pneaumoniae K1, which is the major causative bacterium of hospital-acquired, debilitated and immuno-compromised infections in Taiwan. Its complete genome has been sequenced recently. The overall goal of the program project is to understand the relationship between virulence, CPS (capsular polysaccharide) structure, and biosynthesis of the CPS.

Current Research Targe

Current Research Target

Proposed CPS assembly machinery

Proposed CPS assembly machinery

 

RESEARCH HIGHLIGHTS:

 

 Li TL Research highlight2023
N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry
 Li TL Research highlight
 Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

 

  1. Overcoming resistance (The Scientist)
  2. Dbv29 translation (SciBX) 
  3. Building a better germ-killer (A-IMBN) 
  4. 抗生素興亡史 (科學人第112期2011年6月號) 
  5. 李宗璘博士研究團隊以調整酵素方式成功增強現有抗生素藥效 (中央研究院 院新聞稿) 
  6. New Hopes to Conquer Drug-resistant Problem by Green Chemistry
  7. 醣胜肽類抗生素生合成酵素之探討 (中央研究院 週報第1125期 知識天地) 
  8. Functional Genomics Team Developed Recipes to Generate Key Enzymes in Making Better Antibiotics
  9. Diradicals Identified for the First Time in Sugars Interconversion
  10. Learning from nature: StnK3 is the epimerase controlling β-methyl amino acid stereochemistry
  11. N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry

 

SELECTED PUBLICATIONS: