Hsiao, Michael

MHsiao6x7Professor


mhsiaogateEmail
+886-2-27871243

 

 

EDUCATION AND POSITIONS HELD:

  • D.V.M., National Taiwan University, 1983
  • Ph.D., Pathology, University of Southern California, 1991 Postdoctoral Fellow, University of California at San Diego, 1991–1993
  • Postgraduate Biochemist, University of California at San Diego, 1993–1994
  • Senior Research Associate, Stanford University, 1994–1998
  • Associate Investigator of Medical Education and Research, Kaohsiung Veterans General Hospital, 1998–2005
  • Adjunct Associate Professor of Veterinary Medicine, National Taiwan University, 1998-present
  • Associate Professor, Genomics Research Center, Academia Sinica, 2005-2015
  • Adjunct Associate Professor of Biology, National Defense Medical College, 2006-present
  • Professor, Genomics Research Center, Academia Sinica, 2015-present

HONORS:

  • National Cancer Institute Post-Doctoral Fellowship, 1991-1993
  • First Prize, Tumor Section, Congress for the Neurological Surgeons, 1997
  • Young Investigator Award, American Association for the Neurological Surgeons and Congress for Neurological Surgeons 1998
  • First prize, Taiwan Association for Veterinary Medicine, 1999
  • Second Prize, Asia-Pacific Congress on Oral cavity Cancer, 2008
  • Editorial Board, Am J Cancer Res, 2011
  • ad hoc reviewer for Ann Surg Oncol., BBA-Mol Cell Res, Brit J Cancer, Brit J Dermatol, Cancer, Cancer Gene Therapy, Cancer Lett., Clin Exp Metastas, Gene Ther, Gut, Histol Histopathol, Int J Cancer, J Biomed Biotech, J Cancer Mol, J Phys Chem C, Oncogene, Oral Oncol

RESEARCH INTERESTS:

  • Targeting tumor growth/survival pathways to enhance tumor chemosensitivity and/or radiosensitivity.
  • Novel strategies to overcome tumor metastasis
    • Novel microarray based gene discovery associated with tumor metastasis
    • Viral or pharmacological compounds based inhibition of PI3K/Akt pathway to inhibit tumor invasion and migration
    • Therapeutical interventions using tumor metastasis suppressor genes in preclinical trial settings
    • Establishment of novel real-time 3D quantifiable metastatic tumor models to investigate tumor metastasis dynamics and evaluate therapeutical efficacy
    • Utilization of high-throughput proteomic analysis for the identification of novel tumor metastasis markers and therapeutical evaluations.
  • Development of nanoparticle-mediated high-throughput transfection platforms to identify and characterize novel gene expression functional consequences.

SELECTED PUBLICATIONS:

  • Chi LH, Wu ATH, Hsiao M*, Li YC, 2021, “A Transcriptomic Analysis of Head and Neck Squamous Cell Carcinomas for Prognostic Indications”, JOURNAL OF PERSONALIZED MEDICINE, 11(8), 782. (SCIE)
  • Tsai HF, Chang YC, Li CH, Chan MH, Chen CL, Tsai WC, Hsiao M*, 2021, “Type V Collagen Alpha Promotes the Malignancy of Glioblastoma through the PPRC1-ESM1 Axis Activation and Extracellular Matrix Remodeling”, CELL DEATH DISCOVERY, In Press, e-pub. (SCIE)
  • Kuo KT, Yeh CT, Chen TT, Satriyo PB, Wang CH, Wu ATH, Chao TY, Lee KY, Hsiao M, Wang LS, 2021, “Bruton’s Tyrosine Kinase (BTK) Mediates Resistance to EGFR Inhibition in Non-Small Cell Lung Cancer”, ONCOGENESIS, 10(7), 56. (SCIE)
  • Hsu HJ, Tung CP, Yu CM, Chen CY, Chen HS, Huang YC, Tsai PH, Lin SI Peng HP, Chiu YK, Tsou YL, Kuo WY, Jian JW, Hung FH, Hsieh CY, Hsiao M, Chuang SS, Shen CN, Wang YA, Yang AS, 2021, “Eradicating Mesothelin-positive Human Gastric and Pancreatic Tumors in Xenograft Models with Optimized Anti-mesothelin Antibody–drug Conjugates from Synthetic Antibody Libraries”, SCIENTIFIC REPORTS, 11(1), 15430. (SCIE)
  • Chang YC, Chan MH, Li CH, Fang CY, Hsiao M*, Chen CL, 2021, “Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers [Invited Review]”, BIOMEDICINES, 9(8), 931. (SCIE)
  • Chung SY, Hung YP, Pan YR, Chang YC, Wu CE, Hsu DS, Chang PM, Lu ML, Huang CY, Su Y, Hsiao M, Yeh CN, Chen MH, 2021, “Ruxolitinib Combined with Gemcitabine against Cholangiocarcinoma Growth via the JAK2/STAT1/3/ALDH1A3 Pathway”, BIOMEDICINES, 9(8), 885. (SCIE)
  • Chan MH, Chen W, Li CH, Fang CY, Chang YC, Wei DH, Liu RS, Hsiao M*, 2021, “An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood–Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles”, ACS APPLIED MATERIALS & INTERFACES, 13(23), 26759-26769. (SCIE)
  • Chang YC, Chan MH, Li CH, Yang CJ, Tseng YW, Tsai HF, Chiou J, Hsiao M*, 2021, “Metabolic protein phosphoglycerate kinase 1 confers lung cancer migration by directly binding HIV Tat specific factor 1”, CELL DEATH & DISCOVERY, 7(1), 135. (SCIE)
  • Yuan LT, Lee WJ, Yang YC, Chen BR, Yang CY, Chen MW, Chen JQ, Hsiao M, Chien MH, Hua KT, 2021, “Histone Methyltransferase G9a-Promoted Progression of Hepatocellular Carcinoma Is Targeted by Liver-Specific Hsa-miR-122”, CANCERS, 13(10), 2376. (SCIE)
  • Yang YC, Chien MH, Lai TC, Tung MC, Jan YH, Chang WM, Jung SM, Chen MH, Yeh CN, Hsiao M*, 2021, “Proteomics-based identification of TMED9 is linked to vascular invasion and poor prognoses in patients with hepatocellular carcinoma”, JOURNAL OF BIOMEDICAL SCIENCE, 28(1), 29. (SCIE)
  • Lin TC, Hsiao M*, 2021, “Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments - [Invited Reviews]”, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(6), 2870. (SCIE)
  • Pan JK, Lin CH, Kuo YL, Ger LP, Cheng HC, Yao YC, Hsiao M, Lu PJ, 2021, “MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer”, ONCOGENE, 40(9), 1737-1751. (SCIE)
  • Huang WT, Su TY, Chan MH, Tsai JY, Do YY, Huang PL, Hsiao M*, Liu RS, 2021, “Near-infrared Nanophosphor Embedded in Mesoporous Silica Nanoparticle with High Light-Harvesting Efficiency to Promote Dual Photosystem”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 60(13), 6955-6959. (SCIE)
  • Chuang HH, Zhen YY, Tsai YC, Chuang CH, Huang MS, Hsiao M*, Yang CJ, 2021, “Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy - [Invited Reviews]”, BIOMEDICINES, 9(4), 359. (SCIE)
  • Li LJ, Chang WM, Hsiao M*, 2021, “Aberrant Expression of microRNA Clusters in Head and Neck Cancer Development and Progression: Current and Future Translational Impacts - [Invited Reviews]”, PHARMACEUTICALS, 14(3), 194. (SCIE)
  • Chen CL, Chen CC, Yu WH, Chen SH, Chang YC, Hsu TI, Hsiao M, Yeh CY, Chen CY, 2021, “An annotation-free whole-slide training approach to pathological classification of lung cancer types using deep learning”, NATURE COMMUNICATIONS, 12(1), 1193. (SCIE)
  • Pan KF, Lee WJ, Chou CC, Yang YC, Chang YC, Chien MH, Hsiao M, Hua KT, 2021, “Direct interaction of β‐catenin with nuclear ESM1 supports stemness of metastatic prostate cancer”, EMBO JOURNAL, 40(4), e105450. (SCIE)
  • Cheng CL, Chan MH, Feng SJ, Hsiao M*, Liu RS, 2021, “Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites”, ACS APPLIED MATERIALS & INTERFACES, 13(5), 6099-6108. (SCIE)
  • Chen WY, Wen YC, Lin SR, Yeh HL, Jiang KC, Chen WH, Lin YS, Zhang Q, Liew PL, Hsiao M, Huang J, Liu YN, 2021, “Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance”, COMMUNICATIONS BIOLOGY, 4(1), 22. (SCIE)
  • Pikatan NW, Liu YL, Bamodu OA, Hsiao M, Hsu WM, Haryana SM, Sutaryo S , Chao TY, Yeh CT, 2020, “Aberrantly expressed Bruton’s tyrosine kinase preferentially drives metastatic and stem cell-like phenotypes in neuroblastoma cells”, Cellular Oncology, 43(6):1067-1084. (SCIE)
  • Chang YX, Lin YF, Chen CL, Huang MS, Hsiao M, Liang PH, 2020, “Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3β-β-catenin and XIAP-Survivin Pathways”, Cancers, 12(12), 3865. (SCIE)
  • Chan MH, Chan YC, Liu RS, Hsiao M*, 2020, “A selective drug delivery system based on phospholipid-type nanobubbles for lung cancer therapy”, Nanomedicine, 15(27), 2689-2705. (SCIE) (IF: 4.3; SCI ranking: 19.2%,41.7%)
  • Hung CC, Zhen YY, Niu SW, Hsu JF, Huang LT, Chuang HH, Wang PH, Lin PC, Lee SC, Chiu YW; Wu CH, Huang MH, Hsiao M, Chen HC, Yang CJ, 2020, “Lung Cancer Cell-Derived Secretome Mediates Paraneoplastic Inflammation and Fibrosis in Kidney in Mice”, Cancers, 12(12), 3561. (SCIE)
  • Lai TC, Fang CY, Jan YH, Hsieh HL, Yang YF, Liu CY, Chang PM, Hsiao M*, 2020, “Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-κB signaling pathway”, Cell Communication and Signaling, 18(1), 164. (SCIE)
  • Fang CY, Lai TC, Hsiao M*, Chang YC, 2020, “The Diverse Roles of TAO Kinases in Health and Diseases - [Invited Reviews]”, International Journal of Molecular Sciences, 21(20), 7463. (SCIE)
  • Wen YC, Lin YW, Chu CY, Yang YC, Yang SF, Liu YF, Hsiao M, Lee WJ, Chien MH, 2020, “Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma”, Journal of Pineal Research, Sep; 69(2):e12668. (SCIE)
  • Chang YC, Chen MH, Yeh CN, Hsiao M*, 2020, “Omics-based Platforms: Current Status and Potential Use for Cholangiocarcinoma - [Invited Reviews]”, Biomolecules, 10(10), 1377. (SCIE)
  • Chuang HH, Hsu JF, Chang HL, Wang PH, Wei PJ, Wu DW, Huang MS, Hsiao M*, Yang CJ, 2020, “Pin1 coordinates HDAC6 upregulation with cell migration in lung cancer cells”, International Journal of Medical Sciences, 17(17), 2635-2643. (SCIE)
  • Lai PL, Chen TC, Feng CY, Lin H, Ng CH, Chen Y, Hsiao M, Lu J, Huang HC, 2020, “Selection of a malignant subpopulation from a colorectal cancer cell line”, Oncology Letters, 20(3),2937-2945. (SCIE)
  • Yang YC, Pan KF, Lee WJ, Chang JH, Tan P, Gu CC, Chang WM, Yang SF, Hsiao M, Hua KT, Chien MM, 2020, “Circulating proteoglycan endocan mediates EGFR-driven progression of non-small cell lung cancer”, Cancer Research, Aug 15; 80(16):3292-3304. (SCIE)
  • Lin CH, Hsu TI, Chiou PY, Hsiao M, Wang WC, Chen YC, Lin JT, Wang JY, Lin PC, Lin FC, Tseng YK, Cheng HC, Chen CL, Lu PJ, 2020, “Downregulation of STK4 promotes colon cancer invasion/migration through blocking β‐catenin degradation”, Molecular Oncology, Aug 2; 14(10):2574-2588. (SCIE)
  • Yang YF, Wang YY, Hsiao M, Lo S, Chang YC, Jan YH, Lai TC, Lee YC, Hsieh YC, Yuan SSF, 2020, “IMPAD1 Functions as a Mitochondrial Electron Transport Inhibitor that Prevents ROS Production and Promotes Lung Cancer Metastasis Through the AMPK-Notch1-HEY1 Pathway”, Cancer Letters, Aug 10; 485:27-37. (SCIE)
  • Wu ATH, Srivastava P, Yadav Vijesh K, Tzeng DTW, Iamsaard S, Su ECY, Hsiao M, Liu MC, 2020, “Ovatodiolide, isolated from Anisomeles indica, suppresses bladder carcinogenesis through suppression of mTOR/β-catenin/CDK6 and exosomal miR-21 derived from M2 tumor-associated macrophages”, Toxicology and Applied Pharmacology, Aug 15; 401:115109. (SCIE)
  • Yang YF, Chang YC, Jan YH, Yang CJ, Huang MS, Hsiao M*, 2020, “Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway”, Oncogenesis, Aug 29; 9(8):78. (SCIE)
  • Fan CC, Tsai ST, Yang JC, Chang LC, Chen GY, Sher YP, Wang SC, Hsiao M*, Chang WC, 2020, “EFHD2 Contributes to Non-small Cell Lung Cancer Cisplatin Resistance by the Activation of NOX4-ROS-ABCC1 Axis”, Redox Biology, Jul; 34:101571. (SCIE)
  • Lin YW, Wen YC,Chu CY, Tung MC, Yang YC, Hua KT, Pan KF, Hsiao M, Lee WJ, Chien MH, 2020, “Stabilization of ADAM9 by N-α-acetyltransferase 10 protein contributes to promoting progression of androgen-independent prostate cancer”, Cell Death & Disease, 11(7), 591. (SCIE)
  • Ho CY, Lin YT, Chen HH, Ho WY, Sun GC, Hsiao M, Lu PJ, Cheng PW, Tseng CJ, 2020, “CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats”, Journal of Neuroinflammation, Jun 12; 17(1):185. (SCIE)
  • Chan MH, Huang WT, Wang J, Liu RS, Hsiao M*, 2020, “Next‐Generation Cancer‐Specific Hybrid Theranostic Nanomaterials: MAGE‐A3 NIR Persistent Luminescence Nanoparticles Conjugated to Afatinib for In Situ Suppression of Lung Adenocarcinoma Growth and Metastasis”, Advanced Science, May 6; 7(9):1903741. (SCIE)
  • Yang YC, Chien MH, Lai TC, Su CY, Jan YH, Hsiao M*, Chen CL, 2020, “Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures”, International Journal of Molecular Sciences, Apr 17; 21(8):2813. (SCIE)
  • Chang YC, Yang YF, Chiou J, Tsai HF, Fang CY, Yang CJ, Chen CL, Hsiao M*, 2020, “Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness”, Cell Death & Disease, Mar 18; 11(3):195. (SCIE)
  • Chan YC, Chang YC, Chuang HH, Yang YC, Lin YF, Huang MS, Hsiao M, Yang CJ, Hua KT, 2020, “Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis”, Oncogene, Mar; 39(12):2509-2522. (SCIE)
  • Tan KT, Yeh CN, Chang YC, Cheng JH, Fang WL, Yeh YC, Hsu DS, Wu CE, Liu CY, Chang MS, Lu ML, Chen SJ, Yee C, Hsiao M, Chen MH, 2020, “PRKDC: A New Biomarker and drug target for Checkpoint Blockade Immunotherapy”, Journal for ImmunoTherapy of Cancer, Mar; 8(1):e000485. (SCIE)
  • Chan MH, Hsieh MR, Liu RS, Wei DH, Hsiao M*, 2020, “Magnetically Guided Theranostics: Optimizing Magnetic Resonance Imaging with Sandwich-Like Kaolinite-Based Iron/Platinum Nanoparticles for Magnetic Fluid Hyperthermia and Chemotherapy”, Chemistry of Materials, 32(2) 697-708. (SCIE)
  • Chen JH, Wu ATH, Bamodu OA, Yadav VK, Chao TY Tzeng YM, Mukhopadhyay D, Hsiao M, Lee JC, 2020, “Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts”, Cancers, Jan; 12:56. (SCIE)
  • Huang WT, Chan MH, Chen X, Hsiao M*, Liu RS, 2020, “Theranostic Nanobubble Encapsulating A Plasmon-enhanced Upconversion Hybrid Nanosystem for Cancer Therapy”, Theranostics, Jan 1;10(2):782-796. (SCIE)
  • Pai S, Bamodu OA, Lin YK, Lin CS, Chu PY, Chien MH, Wang LS, Hsiao M, Yeh CT, Tsai JT., 2019, “D47-SIRPα signaling induces epithelial-mesenchymal transition, cancer stemness and links to a poor prognosis in patients with oral squamous cell carcinoma”, Cells, 8(12). (SCIE)
  • Chiou J, Chang YC, Tsai HF, Lin YF, Huang MS, Yang CJ, Hsiao M*, 2019, “Follistatin-like protein 1 inhibits lung cancer metastasis by preventing proteolytic activation of osteopontin”, Cancer Research, 79(24),6113-6125. (SCIE)
  • Li CH, Chang YC, Hsiao M*, Liang SM, 2019, “FOXD1 and Gal-3 form a positive regulatory loop to regulate lung cancer aggressiveness”, Cancers, 11(12). (SCIE)
  • Wen YT, Wu ATH, Bamodu OA, Wei L, Lin CM, Yen Y, Chao TY, Mukhopadhyay D, Hsiao M*, Huang HS, 2019, “A novel multi-target small molecule, LCC-09, inhibits stemness and therapy-resistant phenotypes of glioblastoma cells by increasing miR-34a and deregulating the DRD4/Akt/mTOR signaling axis”, Cancers, 11(10) 1442. (SCIE)
  • Chiou J, Chang YC, Jan YH, Tsai HF, Yang CJ, Huang MS, Yu YL, Hsiao M*, 2019, “Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis”, Scientific Reports, 9(1), 14624. (SCIE)
  • Yang SC, Liu JJ, Wang CK, Lin YT, Tsai SY, Chen WJ, Huang WK, Tu PA, Lin YC, Chang CF, Cheng CL, Lin H, Lai CY, Lin CY, Lee YH, Chiu YC, Hsu CC, Hsu SC, Hsiao M, Schuyler SC, Lu FL, Lu J, 2019, “Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.”, FASEB Journal, 33(9):10577-10592. (SCIE)
  • Chang YC, Tsai HF, Huang SP, Chen CL, Hsiao M*, Tsai WC, 2019, “Enrichment of aldolase C correlates with low non-mutated IDH1 expression and predicts a favorable prognosis in glioblastomas”, Cancers, 11(9). pii: E1238. (SCIE)
  • CH Lin, HY Li, YP Liu, PF Kuo, WC Wang, FC Lin, WL Chang, BS Sheu, YC Wang, WC Hung, HC Cheng, YC Yao, MJ Calkins., M Hsiao, PJ Lu, 2019, “High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma”, Therapeutic Advances in Medical Oncology, 11 175883591987532. (SCIE)
  • Tai PA, Liu YL, Wen YT, Lin CM, Huynh TT, Hsiao M, Wu ATH, Wei L, 2019, “The development and applications of a dual optical imaging system for studying glioma stem cells”, Molecular Imaging, 18:1536012119870899. (SCIE)
  • Chang YC, Chiou J, Yang YF, Su CY, Lin YF, Yang CN, Lu PJ, Huang MS, Yang CJ, Hsiao M*, 2019, “Therapeutic targeting of aldolase A interactions inhibits lung cancer metastasis and prolongs survival”, Cancer Research, 79(18),4754-4766. (SCIE)
  • Jan YH, Lai TC, Yang CJ, Huang MS, Hsiao M*, 2019, “A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma”, Scientific Reports, 9(1), 12329. (SCIE)
  • Chang CY, Chang SL, Leu JD, Chang YC, Hsiao M, Lin LT, Lin HN, Lee YJ, 2019, “Comparison of cofilin1 and Twist1 protein expression in human nonsmall cell lung cancer tissues.”, Oncology Reports, 42(2),805-816. (SCIE)
  • Chan MH, Liu RS, Hsiao M*, 2019, “Graphitic carbon nitride-based nanocomposites and their biological applications: a review.”, Nanoscale, 11(32),14993-15003, Cite 2. (SCIE)
  • Su YK, Bamodu OA, Tzeng YM, Hsiao M, Lin CM, Yeh CT, 2019, “Ovatodiolide inhibits the oncogenicity and cancer stem cell-like phenotype of the glioblastoma cells, as well as potentiate the anticancer effect of temozolomide”, Phytomedicine, 61. (SCIE)
  • Tien CP, Chen CH, Lin WY, Liu CS, Liu KJ, Hsiao M, Chang YC, Hung SC, 2019, “Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.”, Aging (Albany, NY), 11(13),4654-4671.
  • Huang YJ, Jan YH, Chang YC, Tsai HF, Wu ATH, Chen CL, Hsiao M*, 2019, “ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients”, Journal of Clinical Medicine, 8(7), 1070. (SCIE)
  • Hung WY, Chang JH, Cheng Y, Cheng GZ, Huang HC, Hsiao M, Chung CL, Lee WJ, Chien MH, 2019, “Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response”, Cell Death Disease, 10(8):538. (SCIE)
  • Chan MH, Lai CY, Chan YC, Hsiao M*, Chung RJ, Chen X, Liu RS, 2019, “Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing.”, Nanomedicine (London, England), 14(14):1791-1804.
  • Chang WM, Chang YC, Yang YC, Lin SK, Chang MH, Hsiao M*, 2019, “AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway”, Journal of Experimental & Clinical Research, 38, 245.
  • Chien MH, Lin YW, Wen YC, Yang YC, Hsiao M, Chang JL, Huang HC, Lee WJ, 2019, “Targeting the SPOCK1-snail/slug axismediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis”, Journal of Experimental & Clinical Cancer Research, 38:246. (SCIE)
  • Lin TC, Yeh YM, Fan WL, Chang YC, Lin WM, Yang TY, Hsiao M*, 2019, “Ghrelin upregulates oncogenic Aurora A to promote renal cell carcinoma invasion”, Cancers, 11(3), 303. (SCIE)
  • Yeh CN, Chen MH, Chang YC, Wu RC, Tsao LC, Wang SY, Cheng CT, Chiang KC, Chen TW, Hsiao M, Weng WH, 2019, “Over-expression of TNNI3K is associated with early-stage carcinogenesis of cholangiocarcinom”, Molecular Carcinogenesis, 58(2), 270-278. (SCIE)
  • Chuang PK, Hsiao M, Hsu TL, Chang CF, Wu CY, Chen BR, Huang HW, Liao KS, Chen CC, Chen CL, Yang SM, Kuo CW, Chen P, Chiu PT, Chen IJ, Lai JS, Yu CT, Wong CH*, 2019, “Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer”, Proceedings of the National Academy of Sciences of the United States of America, 116(9), 3518-3523. (SCIE)
  • Jan YH, Lai TC, Yang CJ, Lin YF, Huang MS, Hsiao M*, 2019, “Adenylate kinase-4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis”, Journal of Hematology and Oncology, 12(1):12, Cite 3. (SCIE)
  • Chuang HH , Wang PH , Niu SW, Zhen YY, Huang MS, Hsiao M, Yang CJ, 2019, “Inhibition of FAK signaling elicits Lamin A/C-associated nuclear deformity and cellular senescence”, Frontiers in Oncology, 9:22. (SCIE)
  • Liu HW, Su YK, Bamodu OA, Hueng DY, Lee WH, Huang CC, Deng L, Hsiao M, Chien MH, Yeh CT, Lin CM, 2018, “The disruption of the β-catenin/TCF-1/Stat3 signaling axis by 4-Acetylantroquinonol B inhibits the tumorigenesis and cancer stem cell-like properties of glioblastoma cells, in vitro and in vivo”, Cancers, 10(12), 491. (SCIE)
  • Kuo WY, Hsu HJ, Wu CY, Chen HS, Chou YC, Tsou YL, Peng HP, Jian JW, Yu CM, Chiu YK, Chen IC, Tung CP, Hsiao M, Lin CL, Wang YA, Wang AH, Yang AS, 2018, “Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models.”, mAbs, 11(1),153-165. (SCIE)
  • Shu CW, Tzeng YD, Li JY, Liu PF, Kuo SY, Liu LF, Hsieh CW, Lee CH, Wu CH, Hsiao M, Chang HT, 2018, “Kinome-wide siRNA screening identifies Src-enhanced resistance of chemotherapeutic drugs in triple-negative breast cancer cells”, Frontiers in Pharmacology, Nov 9;9:1285. (SCIE)
  • Hung WY, Chang JH, Cheng Y, Chen CK, Chen JQ, Hua KT, Cheng CW, Hsiao M, Chung CL, Lee WJ, Chien MH, 2018, “Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities.”, Cellular Physiology and Biochemistry, 51(1), 337-355.
  • Chuang HH, Huang MS, Wang PH, Liu YP, Hsiao M, Yang CJ, 2018, “Pin1 Is involved in HDAC6-mediated cancer cell motility”, International Journal of Medical Sciences, 15(13), 1573-1581. (SCIE)
  • Chien MH, Lee WJ, Yang YC, Tan P, Pan KF, Liu YC, Tsai HC, Hsu CH, Wen YC, Hsiao M, Hua KT, 2018, “N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas”, Cancer Letters, 433, 86-98. (SCIE)
  • Wu SY, Huang YJ, Tseng YM, Huang CY, Hsiao M, Wu AT, Huang TH, 2018, “Destruxin B suppresses drug-resistant colon tumorigenesis and stemness is associated with the upregulation of miR-214 and downregulation of mTOR/β-catenin pathway”, Cancers, 10(10), 353. (SCIE)
  • Bamodu OA, Yang CK, Tzeng DT, Kuo KT, Huang CC, Deng L, Hsiao M, Lee WH, Yeh CT, 2018, “4-Acetyl-antroquinonol B suppresses SOD2-enhanced cancer stem cell-like phenotypes and chemoresistance of colorectal cancer cells by inducing hsa-miR-324 re-expression”, Cancers, 10(8), 269. (SCIE)
  • Wang PS, Chou CH, Lin CH, Yao YC, Cheng HC, Li HY, Ger LP, Chen YC, Lin FC, Hsiao M*, Lu PJ, 2018, “A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer”, Oncogene, 37(34), 4662-4678, Cite 14. (SCIE)
  • Chang JH, Cheng CW, Yang YC, Chen WS, Hung WY, Chow JM, Chen PS, Hsiao M, Lee WJ, Chien MH, 2018, “Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses.”, Journal of Experimental & Clinical Cancer Research, 37(1), 199. (SCIE)
  • Kuo KT; Huang WC, Bamodu OA, Lee WH, Wang CH, Hsiao M, Wang LS, Yeh CT, 2018, “Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor”, Clinical Epigentics, Aug 9;10(1), 107.
  • Chang YC, Yang YC, Tien CP, Yang CJ, Hsiao M*, 2018, “Roles of aldolase family genes in human cancers and diseases - [Invited Review]”, Trends in Endocrinology and Metabolism, Aug;29(8), 549-559. (SCIE)
  • Huang SP, Chiou J, Jan YH, Lai TC, Yu YL, Hsiao M*, Lin YF, 2018, “Over-expression of lysyl oxidase is associated with poor prognosis and response to therapy of patients with lower grade gliomas”, Biochemical and Biophysical Research Communications, 501(3), 619, 627. (SCIE)
  • Yang YC, Chien MH, Liu HY, Chang YC, Chen CK, Lee WJ, Kuo TC, Hsiao M, Hua KT, Cheng TY, 2018, “Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress.”, Cancer Letters, May 1;421, 28-40. (SCIE)
  • Liu M, Bamodu OA, Kuo KT, Lee WH, Lin YK, Wu ATH, M Hsiao, Tzeng YM, Yeh CT, Tsai JT, 2018, “Downregulation of cancer stemness by novel diterpenoid ovatodiolide inhibits hepatic cancer stem cell-like traits by repressing wnt/b-catenin signaling”, American Journal of Chinese Medicine, 46(4), 891-910. (SCIE)
  • Lin TC, Huang KW, Liu CW, Chang YC, Lin WM, Yang TY, Hsiao M*, 2018, “Leptin signaling axis associates with clinical prognosis and is multifunctional in regulating cancer progression”, Oncotarget, 9(24), 17210-17219.
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