• Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2

    The COVID-19 pandemic seems to be fading away from our daily life, but the threat of a recurring circulation of new variants still haunts. While the vaccines continue being developed for a preventive purpose, the neutralizing antibodies stand in the last line of defense as a therapeutic tool. In the latest publication on "Nature Communications"... Read More

  • The circles Part II: investigating causal relationship between genetic variants and circular RNA expression in autism

    By integrating RNA-sequencing with genotype data from autistic brains, we assessed expression quantitative trait loci of circRNAs (circQTLs) that cis-regulate expression of nearby circRNAs and trans-regulate expression of distant genes (trans-eGenes) simultaneously. Read More

  • MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis

    Ovarian cancer is a highly heterogeneous and malignant female cancer with an overall low survival rate. In particular, advanced ovarian clear cell carcinoma with wildtype p53 has a poor prognosis, drug resistance, metastasis and recurrence. The laboratory of Wendy Hwang-Verslues... Read More

  • New direction for the treatment of Pseudomonas aeruginosa infection combination of anti-CLEC5A monoclonal antibody with antibiotic

    Pseudomonas aeruginosa is one of the most common pathogens for nosocomial infections worldwide. It is commonly found in chronically ill, immunocompromised, and aging peoples. Patients with open wounds, respiratory intubation or drainage tubes are also ... Read More

  • Role of hyperphosphorylation of TDP-43 in the neurodegenerative disease

    A research team led by Dr. Ruby Yun-Ru Chen at Genomic Research Center, aims to study the misfolded protein related to neurodegenerative. They observe that the hyperphosphorylated TDP-43 is found in FTLD patients and start the journey to explore the unknown mechanisms. Read More

  • Crystal structure of 17B receptor complexed with antibody D9 provides solution for guiding antibody humanization and affinity maturation

    A research team led by Dr. Che Ma and Dr. Wen-Hwa Lee in the Genomics Research Center reported a complex crystal structure of IL-17RB with D9, and with the structural information they engineered the phage-dispayed library to facilitate antibody humanization and affinity maturation of D9. Read More
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HONORS & APPOINTMENTS

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    Congratulations to Dr. Wen-Juei Jeng for winning the Best Oral of APASL 2023
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    Congratulations to Dr. Chih-Jen Huang for winning the Best Post of APASL 2023
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    Prof. Li-Jung Juan selected for 2022 Outstanding Scholar Award of Foundation for the Advancement of Outstanding Scholarship
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    Congratulations to Prof. Wei-Chieh Cheng for winning the 1st Professor Kou-Hsiung Lee Memorial Award for Natural Medicine Research
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