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Monoglycosylated spike vaccine is highly effective against COVID-19 variants
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in more than 170 million confirmed cases and over 3.5 million deaths so far. Although there are COVID-19 vaccines available, viruses constantly change through mutations. Key questions remain about how quickly the variants can spread, their potential to evade immunity and how effective the vaccines... Read More
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One Amino Acid Change Twice Immune Effect in CLEC18A to H5N1
LEC18A is a member of C-type lectin family which is known to have influence over innate and adaptive antimicrobial immune responses, and its unknown biological mechanisms is to be unveiled. In the journal Communications Biology, Professor Shi-Liang Hsieh’s team published an article and gave the insight of how CLEC18A ... Read More
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Simplified Procedure to Prepare Remdesivir for SARS-CoV-2 and Nipah Virus
After grappling with the corona virus, SARS-CoV-2, for more than a year, the world is still being haunt-ed by Covid-19. Remdesivir is the first drug approved by the US Food and Drug Administration (FDA) to treat Covid-19. In May 2020, Taiwanese authority also approved the use of remdesivir in patients with severe COVID-19 symptoms. In reality, that price tag is still a price too much to pay for many people. Read More
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NMR: An essential tool to explore biological mysteries at the molecular level
Nuclear magnetic resonance(NMR) is a widely used analytical technique, it has become an essential tool when studying physics, chemistry, materials, and life sciences. With NMR, scientists can dig into the molecular level of a matter to dissect its chemical constructs. Let's see how researchers in Genome Research Center and other Institutes are doing with NMR to leverage their research work in solving the mysteries of the biological matters. Read More
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Pancreatic Cancer Cell Escaping Blueprint Brings Hope to Ease Metastasis
Pancreatic cancer is known to be vicious, pancreatic ductal adenocarcinoma (PDAC) is the type that ac-counts for 95% of pancreatic cancer and so far it is still incurable. An added fact makes PDAC doomed lies in its tendency to have metastasis, meaning cancer cells have already spread to other organs, when diagnosed. Read More
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DSG2 Controls Breast Cancer Metastasis
Breast cancer has been the most common cancer in women worldwide. Even though early detection and therapeutic strategies have made breast cancer less life-threatening and increased the 5-year survival rate to more than 90%, the survival rate is still only 30% for later stage breast cancers that have metastasized. Professor Wendy W. Hwang-Verslues discovered that expression of Desmoglein2 ... Read More
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LATEST PUBLICATIONS
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SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection
Shie-Liang Hsieh
The Journal of Clinical Investigation
June 1, 2021
HONORS & APPOINTMENTS
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Congratulations to Dr. Yun-Ru Ruby Chen for receiving "the 19th Far Eastern Y. Z. Hsu Science and Technology Research Thesis Award"Read More
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Congratulations to Dr. Li-Jung Juan for receiving the MOST 2020 Outstanding Research AwardRead More
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Congratulations to Dr. Shie-Liang Hsieh for receiving the MOST 2020 Outstanding Researcher AwardRead More
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