|Title：||Targeting thymidylate kinase for chemosensitization||Speaker：||Professor Zee-Fen Chang ( Institute of Biochemistry and Molecular Biology, National Yang-Ming University )|
|Date：||2012-06-22 11:00 ～ 12:10|
|Place：||1F Auditorium, Genomics Research Center, Academia Sinica|
|Detail：||Dr. Chang\'s Research Interests focus on:|
1. Nucleotide metabolism in DNA damage
The molecular mechanism regulating dTTP synthesis is coordinated with DNA damage signal for repair. We focus on two research aspects: (i) the mechanism for DNA damage site-specific production of dTTP, (ii) design of small molecules targeting dTTP formation for specific intervention of DNA repair in malignant tumor cells.
2. Assessment of the Rho-ROCK pathway in differentiation and stress response
RhoA/ROCK-mediated contractility is critical for many cellular processes. Currently, we are interested in understanding how RhoA-ROCK pathway regulates (i) gene expression in osteoblast committment in mesenchymal stem cell, (ii) epithelial lumen formation, and (iii) centrosomal overduplication in response to DNA damage.
She has recently identified that thymidylate kinase is likely a common target for cancer treatment. The work has been in press in Cancer Cell.
Host: Dr. Li-Jung Juan