Text Size

Cheng, Soo-Chen

Distinguished Research Fellow


EDUCATION AND POSITIONS HELD:

  • Ph.D., Biochemistry, Duke University (1983)
  • Postdoctor, Laboratory of Molecular Virology, National Institutes of Health (1983-1984)
  • Research Fellow, Senior Research Fellow, Division of Biology, California Institute of Technology (1984-1988)
  • Associate Research Fellow, Institute of Molecular Biology, Academia Sinica (1988-1994)
  • Research Fellow, Institute of Molecular Biology, Academia Sinica (1994-2003)
  • Distinguished Research Fellow, Institute of Molecular Biology, Academia Sinica (2003-present)
  • Adjunct Associate Professor, Institute of Genetics, National Yang Ming University (1989-1990)
  • Adjunct Associate Professor, Adjunct Professor, Institute of Microbiology and Immunology, National Yang Ming University (1990-present)

HONORS:

  • Outstanding Award, National Science Council, Taiwan, ROC, 1994-1995
  • Frontier Science Grant, National Science Council, Taiwan, ROC, 1999-2004
  • Y. Z. Hsu Research Paper Award for Science & Technology, Taiwan, ROC, 2003

RESEARCH INTERESTS:

thumb_Cheng_Soo-Chen_pic01Our research interest is to understand the molecular mechanism of the pre-mRNA splicing reaction using the yeast Saccharomyces cerevisiae as a system. We are particularly interested in the function of protein splicing factors. A protein complex associated with the Prp19 protein (named NTC for nineteen complex) that is required for spliceosome activation has been the major focus of our study. We have used biochemical and genetic methods, as well as analysis of proteomic databases to identify components of this complex, and revealed several proteins that function in various steps of the splicing reaction. Our study of the NTC complex and its associated components provides deep insights into the mechanism of spliceosome assembly.