研究副技師

EDUCATION AND POSITIONS HELD:

• Ph.D., Chemistry, National Taiwan University, 2002
• Postdoctoral Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, 2002-2007
• Assistant Research Specialist, Genomics Research Center, Academia Sinica, 2007-2012
• Mass Spectrometry Facility Manager, 2010-present 
• Associate Research Specialist, Genomics Research Center, Academia Sinica, 2012-present

FACILITY MANAGEMENT / EXPERTISE:

Main job is responsible for the development new mass spectrometry technology and management mass spectrometry core facility in Genomics Research Center. New mass technology is mainly aimed at commercial mass spectrometer can not measured mass range and develops special methods to increase the efficiency of detection. Mass spectrometry core facilities mainly provide routine sample analysis service, mass spectrometry data analysis, proteomics and glycomics molecular structure analysis, analysis software operation services, new staff training course, and to assist users in operating the mass spectrometer. Management of mass spectrometry core facility maintains facility to operate normally and personnel management.

主要工作是負責開發新的質譜技術及管理基因體中心質譜儀核心設施。質譜技術開發目前主要是針對商業化質譜儀無法量測的質量範圍為主要目標，另外也研發特殊的偵測方法增加偵測的效率。質譜儀核心設施主要提供例行性樣品檢測服務，質譜數據分析服務與特定分子結構分析與比對，分析軟體操作服務，新進人員質譜操作教育訓練，協助使用者操作質譜儀。管理基因體中心質譜儀核心設施主要工作是維護設施正常運作與人員管理。

SELECTED PUBLICATIONS:

• Huang CY, Liang CM, Chu CL, Peng JM, Liang SM, 2010, “A fibrillar form of fibronectin induces apoptosis by activating SHP-2 and stress fiber formation.”, APOPTOSIS, 15(8), 915-26. (SCI)
• Huang CY, Liang CM, Chu CL, Peng JM, Liang SM, 2010, “A fibrillar form of fibronectin induces apoptosis by activating SHP-2 and stress fiber formation.”, Apoptosis : an international journal on programmed cell death, 15(8), 915-926. (SCI)
• Y.-C. Cheng, C.-M. Liang, Y.-P. Chen, I.-H. Tsai, C.-C. Kuo & S.-M.Liang, 2009, “F-spondin plays a critical role in murine neuroblastoma survival by maintaining IL-6 expression.”, J. Neurochem., 110(3), 947-955. (SCI)
• C.Y. Huang, C.Y.C.-M. Liang, C.L. Chu, & S.M. Liang, 2009, “Albumin fibrillization induces apoptosis via integrin/FAK/Akt pathway”, BMC Biotechnology, 9, 2. (SCI)
• G. Nagarajan, C. C. Kuo, C. M. Liang, C. M. Chen and S. M. Liang, 2007, “Effects of CpG-B ODN on the protein expression profile of swine PBMC”, Vet Res, 38(6), 795-808. (SCI)
• C. C. Kuo, C. M. Liang, C. Y. Lai and S. M. Liang, 2007, “Involvement of Heat Shock Protein (Hsp)90beta but Not Hsp90{alpha} in Antiapoptotic Effect of CpG-B Oligodeoxynucleotide”, J Immunol, 178(10), 6100-6108. (SCI)
• C. C. Kuo, S. M. Liang and C. M. Liang, 2006, “CpG-B oligodeoxynucleotide promotes cell survival via up-regulation of Hsp70 to increase Bcl-xL and to decrease apoptosis-inducing factor translocation.”, J Biol Chem, 281(50), 38200-38207. (SCI)
• S. A. Kim, C. M. Liang, I. C. Cheng, Y. C. Cheng, M. T. Chiao, C. J. Tseng, F. Lee, M. H. Jong, M. H. Tao, N. S. Yang and S. M. Liang, 2006, “DNA vaccination against foot-and-mouth disease via electroporation: study of molecular approaches for enhancing VP1 antigenicity”, J Gene Med, 8(9), 1182-1191. (SCI)
• Kim, S.-A., Liang, C.-M., Chiao, M.-T., Cheng, I.-C., Lee, F., Jong, M.-H., Tao, M.-H., Tseng, C.J., Yang, N.-S., and Liang, S.-M., 2006, “DNA vaccination against foot-and-mouth disease via electroporation: Study of molecular approaches for enhancing VP1 antigenicity.”, J. Gene Med., 8(9), 1182-1191. (SCI)
• C. C. Kuo, W. T. Lin, C. M. Liang and S. M. Liang, 2006, “Class I and III Phosphatidylinositol 3'-Kinase Play Distinct Roles in TLR Signaling Pathway”, J Immunol, 176(10), 5943-5949. (SCI)
• Cheng-Chin Kuo, Chu-Wei Kuo , Chi-Ming Liang, Shu-Mei Liang, 2005, “A transcriptomic and proteomic analysis of the effect of CpG-ODN on human THP-1 monocytic leukemia cells”, Proteomics, 5(4), 894-906. (SCI)
• J. M. Peng, S. M. Liang and C. M. Liang, 2004, “VP1 of foot-and-mouth disease virus induces apoptosis via Akt signaling pathway”, J Biol Chem, 279(50), 52168-52174. (SCI)
• J. H. Wang, C. M. Liang, J. M. Peng, J. J. Shieh, M. H. Jong, Y. L. Lin, M. Sieber and S. M. Liang, 2003, “Induction of immunity in swine by purified recombinant VP1 of foot-and-mouth disease virus”, Vaccine, 21, 3721-3729. (SCI)
• C. M. Liang, 1999, “Academic point of view on Taiwan's implementation of Health Food Control Act”, 87-92.
• J. Pugin, M. C. Widmer, S. Kossodo, C. M. Liang, H. L. n. Preas and A. F. Suffredini, 1999, “Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators”, Am J Respir Cell Mol Biol, 20, 458-464.
• C. M. Liang, 1999, “Treatment of vascular leakage and related syndrome such as septic shock by administration of metalloproteinase inhibitors”, US patent, #5,866,570.
• P. G. Johnston, 1996, “Monoclonal antibodies specific for human thymidylate synthase”, US patent, 6,221,620.
• D. W. Visscher, M. Hoyhtya, S. K. Ottosen, C. M. Liang, F. H. Sarkar, J. D. Crissman and R. Fridman, 1994, “Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence”, Int J Cancer, 59, 339-344. (SCI)
• M. Hoyhtya, R. Fridman, D. Komarek, K. Porter Jordan, W. G. Stetler Stevenson, L. A. Liotta and C. M. Liang, 1994, “Immunohistochemical localization of matrix metalloproteinase 2 and its specific inhibitor TIMP-2 in neoplastic tissues with monoclonal antibodies”, Int J Cancer, 56, 500-505. (SCI)
• M. K. Bhat, C. Parkison, P. McPhie, C. M. Liang and S. Y. Cheng, 1993, “Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine”, Biochem Biophys Res Commun, 195, 385-392. (SCI)
• S. P. Jiang, 1993, “Development of novel immunoassays to distinguish between the free and complexed forms of matrix metalloproteinase-2 (MMP-2)”, FASEB J, 7, 1211. (SCI)
• R. Fridman, R. E. Bird, M. Hoyhtya, M. Oelkuct, D. Komarek, C. M. Liang, M. L. Berman, L. A. Liotta, W. G. Stetler Stevenson and T. R. Fuerst, 1993, “Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme”, Biochem J, 289, 411-416. (SCI)