研究技師

EDUCATION AND POSITIONS HELD:

• Ph.D. , Biophysics, The Ohio State University ,1997
• Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica , 1997-1999
• NMR Supporting Team Manager, Institute of Biomedical Sciences, Academia Sinica,1999-2002
• NMR Facility Manager, High-Field Biomacromolecular Solution NMR Core Facility, Academia Sinica ,2002-present
• Associate Research Specialist, Genomics Research Center, Academia Sinica, 2004-2010
• Senior Research Specialist, Genomics Research Center, Academia Sinica, 2010-present

FACILITY MANAGEMENT / EXPERTISE:

GRC NMR Facility

As a research specialist, I am responsible for the daily operation on NMR facility and assist researchers carrying out NMR related researches. I have dedicated myself to provide competent and efficient routine service, as well as all aspects of advance technical support on NMR spectroscopy. The duty of my job includes: keeping track of machine time usage; supervising the facility staff members; training users on using NMR spectrometers; developing and implementing new NMR experiments; assisting users setting up advanced NMR experiments; advising users on specific NMR experiments and applications; and providing technical consultation. My expertise is using biophysical methods, especially the NMR approach, to obtain structural and functional information for biomolecules.

主要負責管理基因體中心核磁共振核心實驗室並參與或支援研究人員核磁共振相關研究。服務內容包括：管理核心工作小組確保核心軟硬體正常運作；調控核心所有儀器的時間分配；提供使用者技術及實驗規劃之諮詢；協助蒐集分析圖譜; 訓練新進使用者; 舉辦教育訓練課程；發展或引進核磁共振相關新技術；參與核磁共振相關研究計畫。

SELECTED PUBLICATIONS:

• Ming-Yuan Su, Chung-I Chang and Chi-Fon Chang* , 2012, “1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD ”, Biomolecular NMR Assignments, Online First. (SCI)
• Ching-Yu Chou, Minglee Chu, Chi-Fon Chang, Tai-huang Huang*, 2012, “A compact high-speed mechanical sample shuttle for field-dependent high-resolution solution NMR ”, JOURNAL OF MAGNETIC RESONANCE, 214, 302-308. (SCI)
• M. T. Naik, C. F. Chang, I. C. Kuo, C. C. H. Kung, K. Y. Chua and T.-H Huang, 2008, “Roles of structure and structural dynamics in the antibody recognition of the allergen proteins: A NMR study on Blomia tropicalis major allergen”, Structure, 16, 125-136. (SCI)
• C. F. Chang, H. T. Chou, Y. J. Lin, S. J. Lee, J. L. Chuang, D. T. Chuang and T. H. Huang, 2006, “Structure of the subunit binding domain and dynamics of the di-domain region from the core of human branched chain alpha-ketoacid dehydrogenase complex”, J Biol Chem, 281, 28345-28353. (SCI)