Associate Research Fellow

EDUCATION AND POSITIONS HELD:

• Ph D., Applied Chemistry, National Chiao-Tung University, Hsinchu, Taiwan, 2000
• Postdoctoral Fellow, Academia Sinica, Taiwan, 2000-2006
• Postdoctoral Fellow, The Scripps Research Institute, USA, 2004-2006
• Assistant Research Fellow, Genomics Research Center, Academia Sinica, 2006-2011
• Associate Research Fellow, Genomics Research Center, Academia Sinica, 2011-present 

HONORS:

• Spring Prize of NCTU bronze medal, 1994
• Postdoctoral Fellowship of Academia Sinica, 2000-2004
• Cooperative Post-doctoral Research Visit Program of National Science Council, The Scripps Research Institute (USA), 2004-2006

RESEARCH INTERESTS:

Synthesis of oligosaccharide and development of sugar array.

More than 50% of human proteins are glycosylated. Glycomics has emerged with proteomics as an area for development and exploration in the postgenomic era. In comparison with genomics and proteomics, there are two major problems to defer the development of this field. The first is non automated synthesis of oligosaccharides platform exit. Second is needed to develop a more rapid method in glycoprotein sequencing, developing analytical and biochemical tools and biological readouts to investigate glycan structure-function relationships.
We focus on the development of novel and efficient methodologies to prepare biologically potent oligosaccharides and design the new type sugar array to address the bio-function of oligosaccharides.

Glycan Array and Its Applications	Carbohydrate-based vaccines design	Ultrasensitive naked eye detection

SELECTED PUBLICATIONS:

• T.-C. Hung, C.-W. Lin, T.-L. Hsu, C.-Y. Wu, C.-H. Wong , 2013, “Investigation of SSEA-4 Binding Protein in Breast Cancer Cells”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, in press. (SCI)
• Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu*, C.-H. Wong*, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2517-22. (SCI)
• T.-J. R. Cheng, S.-Y. Wang, W.-H. Wen, C.-Y. Su, M. Lin, W.-I. Huang, M.-T. Liu, H.-S. Wu, N-S. Wang, C.-K. Cheng, C.-L. Chen, C.-T. Ren, C.-Y. Wu, J.-M. Fang, Y.-S. E. Cheng and C.-H. Wong, 2013, “Chemical probes for drug resistance assessment by binding competition (RABC) oseltamivir susceptibility evaluation”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(1), 366–370. (SCI)
• Wu C.-H., Yen C.-J., Chou R.-H., Li S.-T., Huang W.-C., Ren C.-T., Wu C.-Y.*, Yu Y.-L.*, 2012, “Cancer-Associated Carbohydrate Antigens as Potential Biomarkers for Hepatocellular Carcinoma.”, PLoS One, 7, e39466. (SCI)
• Chung-Yi Wu; Hui-Chang Lin; Hsien-Jen Wu, 2012, “Sythesis of New Acetal Aza-Cage Compounds via Ozonolysis of Bis-endo-diol- and Diacylnornornese Derivatives”, TETRAHEDRON, 68, 2100-2106. (SCI)
• D Punyadarsaniya, C-H Liang, C Winter, H Petersen, S Rautenschlein, I Hennig-Pauka, C Schwegmann-Wessels, C-Y Wu, C-H Wong, G Herrler* , 2011, “Infection of differentiated porcine airway epithelial cells by influenza virus: differential susceptibility to infection by porcine and avian viruses”, PLoS One, 6(12), e28429. (SCI)
• Che-Hsiung Hsu, Shang-Cheng Hung*, Chung-Yi Wu*, and Chi-Huey Wong*, 2011, “Toward Automated Oligosaccharide Synthesis”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(50), 11872-11923. (SCI)
• K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, J.-L. Han, B. Pal, T.-A. Chao, S.-H. Wu, C.-H. Wong* and C.-Y. Wu*, 2011, “Efficient and Stereoselective Synthesis of alpha(2→9) Oligosialic Acids: From Monomers to Dodecamers”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 9391-9395. (SCI)
• H-L Yen, C-H Liang, C-Y Wu, H Forrest, A Ferguson, KT Choy, J Jones, DDY Wong, PPH Cheung, C-H Hsu, OT Li, KM Yuen, RWY Chan, LLM Poon, MCW Chan, J Nicholls, S Krauss, C-H Wong, Y Guan, RG Webster, RJ Webby & JSM Peiris* , 2011, “Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 14264-14269. (SCI)
• Bin-Ling Tsai, Jeng-Liang Han, Chien-Tai Ren, Chung-Yi Wu* and Chi-Huey Wong*, 2011, “Programmable One-Pot Synthesis of Lewis X dimer and KH-1 epitopes”, TETRAHEDRON LETTERS, 52(17), 2132-2135. (SCI)
• Chen MW, Liao HY, Huang Y, Jan JT, Huang CC, Ren CT, Wu CY, Cheng TJ, Ho DD, Wong CH, 2011, “Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglut”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(9), 3510-3515. (SCI)
• Chung-Yi Wu* and Chi-Huey Wong*, 2011, “Chemistry and Glycobiology”, CHEMICAL COMMUNICATIONS, 47, 6201-6207. (SCI)
• Liang, C.-H., Wang, S.-K., Lin, C.-W., Wong, C.-H.*, Wu, C.-Y.*, 2011, “Effects of neighboring glycans on antibody-carbohydrate interaction”, Angewandte chemie-international edition, 50(7), 1608-1612. (SCI)
• Chung-Yi Wu* and Chi-Huey Wong*, 2011, “Programmable One-Pot Glycosylation”, Topics in Current Chemistry, 301, 223-252. (SCI)
• Y.-L. Huang, C.-Y. Wu*, 2010, “Carbohydrate-Based Vaccines: Challenges and Opportunities”, Expert review of vaccines, 9 (11), 1257-1274. (SCI)
• Chen-I Wu, Yi-Sheng Wang, Nelson G. Chen, Chung-Yi Wu and Chung-Hsuan Chen*, 2010, “Ultrasound Ionization of Biomolecules”, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 24, 2569-2574. (SCI)
• Liang, C.-H.; Wu, C.-Y.*, 2010, “Glycomics: Relevance for Personalized Medicine”, Current Pharmacogenomics and Personalized Medicine, 8, 49-63.
• Hsu, C.-H.; Chu, K.-C.; Lin, Y.-S.; Han, J.-L.; Peng, Y.-S.; Ren, C.-T.; Wu, C.-Y.* and Wong, C.-H.*, 2010, “Highly Alpha-Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides.”, Chemistry-A European Journal, 16(6), 1754-1760. (SCI)
• Liao H-Y, Hsu C-H, Wang S-C, Liang C-H, Ye H-Y, Su C-Y, Jan J-T, Ren C-T, Cheng T.-J R,* Wu C-Y*, Wong C-H*, 2010, “Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays”, Journal of the American Chemical Society, 132, 14849-14856. (SCI)
• Shih-Huang Chang, Jeng-Liang Han, Susan Y. Tseng, Hsin-Yu Lee, Chin-Wei Lin, Yu-Chen Lin, Wen-Yih Jeng, Andrew H.-J. Wang, Chung-Yi Wu,* Chi-Huey Wong*, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides through Phosphonate Chemistry”, Journal of the American Chemical Society, 132, 13371-13380. (SCI)
• Liang C-H, Wu,C-Y*, 2009, “Glycan Array: A Powerful Tool for Glycomics Studies”, Expert Review of Proteomics, 6(6), 631-645. (SCI)
• Wang, C.-C.; Chen, J.-R.; Tseng, Y.-C.; Hsu, C.-H.; Hung, Y.-F.; Chen, S.-W.; Chen, C.-M.; Khoo, K.-H.; Cheng, T.-J.; Cheng, Y.-S.; Jan, J.-T.; Wu, C-Y., Ma, A.C.*; Wong, C-H*, 2009, “Glycans on influenza hemagglutinin affect receptor binding and immune response ”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(43), 18137-18142. (SCI)
• Chi-Hui Linag,Cheng-Chi Wang,Yu-Chen Lin,Chung-Hsuan Chen,Chi-Huey Wong*,Chung-Yi Wu*, 2009, “Iron Oxide/Gold Core/Shell Nanoparticle for Ultrasensitive Detection of Carbohydrate-Protein Interactions”, Analytical Chemistry, 81, 7750-7756. (SCI)
• Chung-Yi Wu*, Pi-Hui Liang*, Chi-Huey Wong*, 2009, “New development of glycan arrays”, ORGANIC & BIOMOLECULAR CHEMISTRY, 7(11), 2247-2254. (SCI)
• Susan Y. Tseng, Cheng-Chi Wang, Chin-Wei Lin, Cheng-Lung Chen, Wen-Yueh Yu, Chung-Hsuan Chen, Chung-Yi Wu*, Chi-Huey Wong*, 2008, “Glycan arrays on aluminum-coated glass slides.”, CHEMISTRY-AN ASIAN JOURNAL, 3(8-9), 1395-1405.. (SCI) (IF: 4.5; SCI ranking: 17.5%)
• Pi-Hui Liang, Chung-Yi Wu, William A. Greenberg, Chi-Huey Wong*, 2008, “Glycan arrays: biological and medical applications.”, CURRENT OPINION IN CHEMICAL BIOLOGY, 12(1), 86-92 2008. (SCI)
• Nien-Yeen Hsu, Susan Yu Tseng, Chung-Yi Wu, Chien-Tai Ren, Yuan-Chang Lee, Chi-Huey Wong, Chung-Hsuan Chen*, 2008, “Desorption ionization of biomolecules on metals.”, ANALYTICAL CHEMISTRY, 80(13), 5203-5210. (SCI)
• Cheng-Chi Wang,Yen-Lin Huang, Chien-Tai Ren, Chin-Wei Lin, Jung-Tung Hung, Jyh-Cherng Yu, Alice L. Yu*, Chung-Yi Wu*, Chi-Huey Wong*, 2008, “Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer. ”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(33), 11661-11666. (SCI)
• A. Brik, C.Y. Wu, C. H. Wong*, 2006, “Microtiter Plate Based Chemistry and In Situ Screening: A Useful Approach for Rapid Inhibitors Discovery”, ORGANIC & BIOMOLECULAR CHEMISTRY, 4, 1446-1457. (SCI)
• J.C. Lee, Chung-Yi Wu, J.V. Apon, G. Siuzdak and C.H. Wong, 2006, “Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photocleavable DIOS-MS sugar array”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 45, 2753-2757. (SCI)
• Chung-Yi Wu, K. Y. King, C. J. Kuo, J. M. Fang, Y. T. Wu, M. Y. Ho, C. L. Liao, J. J. Shie, P. H. Liang and C. H. Wong, 2006, “Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Stndrome 3CL Protease”, Chem Biol, 13, 261-268. (SCI)
• C. Y. Wu, A. Brik, S. K. Wang, Y. H. Chen and C. H. Wong, 2005, “Tetrabutylammonium Fluoride-Mediated Rapid Alkylation Reaction in Microtiter Plates for Discovery of Enzyme Inhibitors in Situ”, Chembiochem, 6, 2176-2180. (SCI)
• C. F. Chang, C. W. Ho, Chung-Yi Wu, T. A. Chao, C. H. Wong*, C. H. Lin*, 2004, “Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.”, Chem Biol, 11(9), 1301-1306. (SCI)
• Chung-Yi Wu, J. T. Jan*, S. H. Ma, C. J. Kuo, H. F. Juan, Y. H. E. Cheng, H. H. Hsu, R. H. Liu, J. M. Fang, P. H. Liang and C. H. Wong*, 2004, “Small molecules targeting Severe Acute Respiratory Syndrome (SARS) human coronavirus”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 10012-10017. (SCI)
• Chung-Yi Wu, C. F. Chang, J. S. Y. Chen, C. H. Wong*, C. H. Lin*, 2003, “Rapid Diversity-Oriented Synthesis in Microtiter Plates for in situ Screening: Discovery of Potent and Selective a-Fucosidase Inhibitors”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 42(38), 4661-4664. (SCI)