研究員 / 本院生化所

EDUCATION AND POSITIONS HELD:

• B.S. in Chemistry, National Taiwan University (1990)
• Ph.D. in Chemistry, Scripps Research Institute (1995)
• Postdoctoral Fellow, Harvard Medical School (1995- 1997)
• Assistant Research Fellow, Inst of Biol Chem, Academia Sinica (1997- 2002)
• Associated Research Fellow, Inst of Biol Chem, Academia Sinica (2002- present)
• Adjunct Associate Professor in Institute of Biochemical Sciences, National Taiwan University (2002- present)

HONORS:

• Heritage Prize and Fellowship of the Lee Foundation, 1998- 1999.
• A co-recipient of the Presidential Green Chemistry Challenge Award honoring C.-H. Wong, 2000
• Secretary-general, the Biophysics Society of Taiwan, 2002– present
• Board member of the Glycoscience Foundation, Taiwan: 2004– present

RESEARCH INTERESTS:

Chemical Biology and Drug Discovery

Research in Lin’s lab involves multi-disciplinary areas including glycobiology, enzymology, synthetic chemistry and biophysics. Emphasis is stressed on the carbohydrate-related enzymes, in particular in association with pathogenic bacteria and viruses. Development of enzyme inhibitors has been carried out to investigate how small molecules interact with proteins and in turn, understand how potent enzyme inhibitors intervene in the pathogenesis. It is our primary concern to develop both synthetic and bioorganic strategies to serve the aforementioned purposes.

In addition, we are highly interested to study non-covalent interaction involved in the protein quaternary structure by using various biophysical methods (including analytical ultracentrifugation and nanospray-ESI-MS) as these approaches can be applied to decipher protein-protein interaction.

我們的工作著重在新藥研發，研究的範圍涵蓋化學與生物兩大領域；包括酵素學、醣生物學、合成化學、及生物物理。主要是針對病原性細菌和病毒，它們與醣類生合成相關的酵素，從酵素抑制物的開發來探討這些小分子，如何與標的蛋白結合，進一步了解抑制活性高的分子，是怎樣去干擾病原微生物的感染。為了因應上述目的，我們致力於開發合成化學與生物有機相關的研究方法。

此外，我們也使用一些生物物理的方法，例如分析型超高速離心、電子噴灑離子化質譜技術，探討在蛋白質四級結構中的非共價性結合的交互作用，希望所得的結果能夠應用在蛋白質與蛋白質的交互作用。