研究助技師 / 本院細生所

EDUCATION AND POSITIONS HELD:

• Ph.D., Reproductive Genetics, University of London (2001)
• Postdoctoral Fellow, Oregon National primate Research Center, Oregon Health and Science University (2000-2003)
• Staff Scientist, Oregon National primate Research Center, Oregon Health and Science University (2003-2004)

HONORS:

• Research Creation Award for Undergraduate Students, NSC, Taiwan, 1993
• St Thomas’ trustee Scholarship, 1997
• King’s College Scholarship, 1998
• NIH postdoctoral fellowship, 2000

RESEARCH INTERESTS:

As the first step of exploring the potential application of primate ES cells for cellular therapy, drug discovery and biomedical research, we have established strategy for isolating, enriching and characterizing neural, cardiac and pancreatic cells from monkey and human ES cells. We have also derived new ES cell lines from non-human primates to investigate the fundamental cellular and molecular mechanisms governing pluripotency and differentiation of ES cells. The current main objectives of our lab are to (1) Characterize the cellular and molecular events underlying totipotency and pluripotency during preimplantatio development and their implication for pluripotent cell isolation. (2) Use ES cells as an in vitro model for organogenesis, with emphasis on in vitro formation of embryonic hear structure, pancreatic islets and craniofacial tissues. (3) Derivation of germ cells from primate embryonic stem cells.

我們的研究重點在於利用胚胎幹細胞之豐富分化潛力去探討其在細胞性治療，新藥開發及生物醫學研究之應用。 目前,我們已成功的建立數個恆河猴之胚胎幹細胞系並從其中分離出神經、胰島及心肌細胞。經由此一研究平台之建立，我們將進一步去探討維持胚胎幹細胞萬能分 化潛力及其控制分化之分子機轉。同時, 我們亦將利用胚胎幹細胞去探討在體外器官如心臟，胰島，頭面組織及精細胞形成之機轉。