教授 / 台大化學所

EDUCATION AND POSITIONS HELD:

• Ph.D., Chemistry, Yale University, 1980.
• Professor, Department of Chemistry, National Taiwan University, 1986-present.
• Postdoctoral Fellow, Columbia University / Suntory Institute for Bioorganic Research (Osaka), 1981-1982.
• Chairman, Department of Chemistry, National Taiwan University, 1993-1996.
• Director, National Taiwan University Instrumentation Center (Analysis and Measurement Division), 1998-2001.
• Joint Appointment Research Fellow, Genomic Research Center, Academia Sinica, 2003-present.

HONORS:

• National Science Council Award for Outstanding Research, 1987-96 (five times).
• Sun Yat-Sen Award for Academic Publications, 1992.
• National Science Council Invited Principal Investigator, 1997-2003.
• Chinese Chemical Society Award, 1997.
• Chair Professor, Foundation for Advancement of Outstanding Scholarship, 1999-2004.
• National Taiwan University Award for Teaching Excellence, 1999.

RESEARCH INTERESTS:

Organic synthesis
synthetic methods and asymmetric catalysis.

Bioorganic and medicinal chemistry
molecular recognition, heterocyclic chemistry, natural products, nanobiotechnology, and drug discovery.

我們的研究工作著重於有機合成化學之設計，包括不對稱催化反應，如利用釤離子和硫醇共同催化多步驟一鍋式立體選擇性之反應，將5-酮基醛轉變成內酯，可類 比從丙酮酸轉變成acetyl CoA的生化作用。從有機化學出發，我們的研究也擴展到生物分子辨識、醫藥化學和奈米生物科技，如設計合成超靈敏螢光檢測葡萄糖的試劑，結合時從天藍色變 成放射草綠色螢光。又如投入抗SARS藥物的開發研究，設計合成3CL蛋白酵素之抑制劑，用以防止SARS冠狀病毒之複製。