Wu, Ying-Ta 吳盈達

研究技師


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Telephone: 02-27871237
[ CV ]

 

 

EDUCATION AND POSITIONS HELD:

  • Ph.D., Chemical Engineering Department of State University of New York at Buffalo, 1990–1996
  • Postdoctoral Fellow, Academia Sinica, Taipei, 1996–2001
  • Manager of Administrative Office of National Research Program for Genomic Medicine, 2001–2004
  • Assistant Research Specialist of Genomic Research Center, Academia Sinica, Taipei, 2004–2007
  • Associate Research Specialist of Genomic Research Center, Academia Sinica, Taipei, 2007-2012
  • Senior Research Specialist of Genomic Research Center, Academia Sinica, Taipei, 2012-present

FACILITY MANAGEMENT / EXPERTISE:

Structural Function to Drug Discovery

image002Our research will devote to facilitate technology for probing hot-area that link to specific function in biomolecular recognition and biomolecule-compound interactions, and to devise strategies for structure-based drug discovery as an integral part of the AS-GRC chemical biology research. The major duty, therefore, is to maintain an up-to-date in silico drug discovery platform and to implement new selection methods to assist research PIs in defining features of research targets for drug discovery. Computational approach will be using local surface searching, docking, and fragment-based filling methods, for starting template generation as well as for lead optimization.

研究興趣在致力於開發探測包括:蛋白質、DNA和RNA等生物分子間相互識別,以及生物分子與藥物間相互作用的技術,用以增進發現生物分子連絡特定功能的結構上熱區,結合使用結構為基礎的藥物設計策略,作為中心進行生物化學研究的整合技術。因此主要任務為維繫藥物研發技術平臺,以提供研究人員確定其標的物作為藥物設計目標的特徵。計算方法結合區域性的表面搜查,空間對接,片段底模充填法等技巧,以產生起始模板的結構資訊,以及進行先導藥物最佳化設計。

SELECTED PUBLICATIONS:

  • Chen SH, Hwang DR, Chen GH, Hsu NS, Wu YT, Li TL, Wong CH, 2012, “Engineering Transaldolase in Pichia stipitis to Improve Bioethanol Production”, ACS CHEMICAL BIOLOGY, 7(3), 481-486. (SCI)
  • Shen YF, Chen YH, Chu SY, Lin MI, Hsu HT, Wu PY, Wu CJ, Liu HW, Lin FY, Lin G, Hsu PH, Yang AS, Cheng YS, Wu YT, Wong CH, Tsai MD, 2011, “E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 16515-16520. (SCI)
  • Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, 2010, “High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(45), 19151-19156. (SCI)
  • Tu S, Teng YC, Yuan C, Wu YT, Chan MY, Cheng AN, Lin PH, Juan LJ, Tsai MD, 2008, “The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif”, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 15(4), 419-421. (SCI)
  • C. M. Huang, Y. T. Wu and S. T. Chen, 2000, “Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis”, CHEMISTRY & BIOLOGY, 7, 453-461. (SCI)
  • Y.-T. Wu, H.-P. Hsieh, S.-T. Chen and K.-T. Wang, 1998, “Dihydropyran-2-carboxylic Acid, a Novel Bifunctional Linker for the Solid Phase Synthesis of Peptides Containing a C-terminal Alcohol”, CHEMICAL COMMUNICATIONS, 649-650. (SCI)