Mao, Shi-Shan 毛溪山

mao研究技師


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Telephone: 02-27871303

 

EDUCATION AND POSITIONS HELD:

  • B.S. National Tsing Hua University, Tsin-chu, Taiwan, ROC, 1978
  • Ph. D. The Johns Hopkins University, Baltimore, MD, 1987
  • Postdoctoral Fellow, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, 1987-1990
  • Senior Research Fellow, MERCK & CO., INC., West Point, PA, 1990-2006
  • Senior Research Specialist, Genomics Research Center, Academia Sinica, 2007-present

MEMBERSHIPS:

  • American Chemical Society
  • American Association for the Advancement of Science
  • American Society for Biochemistry and Molecular Biology

EXPERTISE / SPECIALTY:

The combined experience in both academic and industrial provides me the foundation for both basic research and drug discovery and development. I have extensive learning in biochemistry, enzymology, natural product biosynthesis during my academic years. My current works at Academia Sinica are in two parts: helping technology transfer of Academia Sinica research discoveries and coordinating the operation and collaboration of high through-put screening.

在學術界以及工業界的雙重經驗讓我在基礎研究及新藥開發方面都有良好的根基,在學術界從事研究期間,我大量的學習到有關生物化學、酵素化學及天然物合成方面的知識,目前我在中央研究院的工作分成兩個部份:協助中研院研究成果技術移轉,以及協調高速藥物篩選計劃的運作及合作研究。

SELECTED PUBLICATIONS:

  • Liverton, N et al, 2008, “A Molecular Modeling Based Approach to Potent P2-P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130, 4608-4609. (SCI)
  • Hsu, H-J., Tsai, K-C., Sun, Y-K., Chang, H-J., Huang, Y-J., Yu, H-M., Lin, C-H., Mao, S-S., and Yang, A-S, 2008, “Factor Xa Active Site Substrate Specificity with Substrate Phage Display and Computional Molecular Modeling”, JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 12343-12353. (SCI)
  • Mao, S-S., DiMuzio, J., McHale, C., Burlein, C., Olsen, D., and Carroll, S. , 2007, “A Time-Resolved Fluorescence Assay to Characterize Inhibition of Hepatitis C Virus Nonstructural Protein 3-4A Protease at Low Enzyme Concentrations”, ANALYTICAL BIOCHEMISTRY, 373, 1-8. (SCI)
  • Mao, S.-S., Holahan, M. A., Bailey, C., Wu, G., Colussi, D., Carroll, S. S., and Cook, J. J., 2005, “Demonstration of Enhanced Endogenous Fibrinolysis in Thrombin Activatable Fibrinolysis Inhibitor-Deficient Mice”, BLOOD COAGULATION & FIBRINOLYSIS, 16, 407-425. (SCI)
  • Nantermet, P., Barrow, J. C., Lindsley, S. R., Young, M, Mao, S-S., Carroll, S., Bailey, C., Bosserman, M., Colussi, D., McMaster, D. R., Vacca, J. P., and Selnick, H. G., 2004, “Imidazole Acetic Acid TAFIa Inhibitors: SAR Studies Centered around the Basic P1’ Group”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14, 2141-2145. (SCI)
  • Mao, S-S., Colussi, D., Bailey, C. M., Bosserman, M., Burlein, C., Gardell, S. J., and Carroll, S. S. , 2003, “An Electrochemiluminescence Assay for Basic Carboxypeptidases: Inhibition of Basic Carboxypeptidases and Activation of Thrombin-Activatable Fibrinolysis Inhibitor”, ANALYTICAL BIOCHEMISTRY, 319, 159-170. (SCI)
  • Ferrer, M, Zuck, P., Kolodin, G., Mao, S-S., Peltier, R. R., Bailey, C., Gardell, S. J., Strulovici, B., and Inglese, J. , 2003, “Miniaturizable Homogeneous Time-resolved Fluorescence Assay for Carboxypeptidase B Activity”, ANALYTICAL BIOCHEMISTRY, 317, 94-98. (SCI)
  • Barrow, J. C. et al, 2003, “Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activatable Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics”, JOURNAL OF MEDICINAL CHEMISTRY, 46, 5294-5297. (SCI)
  • Mao, S-S., Cooper, C. M., Wood, T., Shafer, J. A., and Gardell, S. J., 1999, “Characterization of Plasmin-Mediated Activation of Plasma Procarboxypeptidase B: Modulation by Glycosaminoglycans”, JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 35046-35052. (SCI)
  • Mao, S-S., Przysiecki, C. T., Krueger, J. A., Cooper, C. M., Lewis, S. D., Joyce, J., Lellis, C., Garsky, V. M., Sardana, M., and Shafer, J. A. , 1998, “Selective Inhibition of Factor Xa in the Prothrombinase Complex by the Carboxy-Terminal Domain of Antistasin”, JOURNAL OF BIOLOGICAL CHEMISTRY, 273, 30086-3009`. (SCI)
  • Feng, D-M. et al, 1997, “Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position”, JOURNAL OF MEDICINAL CHEMISTRY, 40, 3726-3733. (SCI)
  • Mao, S.-S., Huang, J., Welebob, C., Neeper, M. P., Garsky, V. M., and Shafer, J. A., 1995, “Identification and Characterization of Tick Anticoagulant Peptide with Increased Inhibitory Potency Toward Human Factor Xa”, BIOCHEMISTRY, 34, 5098-5103. (SCI)
  • Lewis, S. D. et al, 1995, “Inhibition of Thrombin by Peptides Containing Lysyl-a-Keto Carbonyl Derivatives”, THROMBOSIS AND HAEMOSTASIS, 74, 1107-1112. (SCI)
  • Mao, S.S., 1994, “Factor Xa Inhibitors”, Perspectives in Drug Discovery and Design, 1, 423-429.
  • Mao, S. S., Holler, T. P., Yu, G. X., Bollinger, J. M., Booker, S., Johnston, M. I., and Stubbe, J. , 1992, “A Model for the Role of Multiple Cysteine Residues involved in Ribonucleotide Reduction: Amazing and still Confusing”, BIOCHEMISTRY, 31, 9733-9743. (SCI)
  • Mao, S. S., Yu, G. X., Chalfoun, D., and Stubbe, J., 1992, “Characterization of C439SR1, a Mutant of Escherichia coli Ribonucleotide Diphosphate Reductase: Evidence that C439 Is a Residue Essential for Nucleotide Reduction and C439SR1 Is a Protein Possessing Novel Thioredoxin-like Activity”, BIOCHEMISTRY, 32, 9752-9759. (SCI)
  • Mao, S. S., Holler, T. P., Bollinger, J. M., Yu, G. X., Johnston, M. I., and Stubbe, J. , 1992, “Interaction of C225SR1 Mutant Subunit of Ribonucleotide Reductase with R2 and Nucleotide Diphosphates: Tales of a Suicidal Enzyme”, BIOCHEMISTRY, 32, 9744-9751. (SCI)
  • Jordan, S. P., Mao, S. S., Lewis, S. D., and Shafer, J. A.*, 1992, “Reaction Pathway for Inhibition of Blood Coagulation Factor Xa by Tick Anticoagulant Peptide”, BIOCHEMISTRY, 56, 728-731. (SCI)
  • Krol, W. J., Mao, S. S., Steele, D. L. and Townsend, C. A.*, 1991, “Stereochemical Correlation of Proclavaminic Acid and Synthesis of erythro- and threo-L-Hydroxyornithine from an Improved Vinylglycine Synthon”, JOURNAL OF ORGANIC CHEMISTRY, 56, 728-731. (SCI)
  • Mao, S.-S., Johnston, M. I., Bollinger, J. M., and Stubbe, J. , 1989, “Mechanism-based Inhibition of A Mutant Escherichia coli Ribonucleotide Reductase (cysteine-225->Serine) By Its Substrate CDP”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 86, 1485-1489. (SCI)
  • Townsend, C. A.*, and Mao, S.-S., 1987, “Clavulanic Acid Biosynthesis: The Stereochemical Course of b-Lactam Formation from Chiral Glycerol”, Chem. Comm., 86-89.
  • Townsend, C. A.*, Ho, M-F., and Mao, S.-S., 1986, “The Stereochemical Fate of (2RS,5R)- and (2RS,5S)-[5-3H]-Ornithine in Clavulanic Acid Biosynthesis”, Chem. Comm., 638-639.