Hsiao, Michael 蕭宏昇


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Telephone: 02-27871243




  • D.V.M., National Taiwan University, 1983
  • Ph.D., Pathology, University of Southern California, 1991 Postdoctoral Fellow, University of California at San Diego, 1991–1993
  • Postgraduate Biochemist, University of California at San Diego, 1993–1994
  • Senior Research Associate, Stanford University, 1994–1998
  • Associate Investigator of Medical Education and Research, Kaohsiung Veterans General Hospital, 1998–2005
  • Adjunct Associate Professor of Veterinary Medicine, National Taiwan University, 1998-present
  • Associate Research Fellow, Genomics Research Center, Academia Sinica, 2005-2015
  • Adjunct Associate Professor of Biology, National Defense Medical College, 2006-present
  • Research Fellow, Genomics Research Center, Academia Sinica, 2015-present


  • National Cancer Institute Post-Doctoral Fellowship, 1991-1993
  • First Prize, Tumor Section, Congress for the Neurological Surgeons, 1997
  • Young Investigator Award, American Association for the Neurological Surgeons and Congress for Neurological Surgeons 1998
  • First prize, Taiwan Association for Veterinary Medicine, 1999
  • Second Prize, Asia-Pacific Congress on Oral cavity Cancer, 2008
  • Editorial Board, Am J Cancer Res, 2011
  • ad hoc reviewer for Ann Surg Oncol., BBA-Mol Cell Res, Brit J Cancer, Brit J Dermatol, Cancer, Cancer Gene Therapy, Cancer Lett., Clin Exp Metastas, Gene Ther, Gut, Histol Histopathol, Int J Cancer, J Biomed Biotech, J Cancer Mol, J Phys Chem C, Oncogene, Oral Oncol


  • Targeting tumor growth/survival pathways to enhance tumor chemosensitivity and/or radiosensitivity.
  • Novel strategies to overcome tumor metastasis
    • Novel microarray based gene discovery associated with tumor metastasis
    • Viral or pharmacological compounds based inhibition of PI3K/Akt pathway to inhibit tumor invasion and migration
    • Therapeutical interventions using tumor metastasis suppressor genes in preclinical trial settings
    • Establishment of novel real-time 3D quantifiable metastatic tumor models to investigate tumor metastasis dynamics and evaluate therapeutical efficacy
    • Utilization of high-throughput proteomic analysis for the identification of novel tumor metastasis markers and therapeutical evaluations.
  • Development of nanoparticle-mediated high-throughput transfection platforms to identify and characterize novel gene expression functional consequences.


  • Jan YH, Lai TC, Yang CJ, Lin YF, Huang MS, Hsiao M*, 2019, “Adenylate kinase-4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis”, Journal of Hematology and Oncology, In Press. (SCI)
  • Wang PS, Chou CH, Lin CH, Yao YC, Cheng HC, Li HY, Ger LP, Chen YC, Lin FC, Hsiao M*, Lu PJ, 2018, “A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer”, Oncogene, 37(34), 4662-4678. (SCI)
  • Chang YC, Yang YC, Tien CP, Yang CJ, Hsiao M*, 2018, “Roles of aldolase family genes in human cancers and diseases”, Trends in Endocrinology and Metabolism, Aug;29(8), 549-559. (SCI)
  • Huang SP, Chiou J, Jan YH, Lai TC, Yu YL, Hsiao M*, Lin YF, 2018, “Over-expression of lysyl oxidase is associated with poor prognosis and response to therapy of patients with lower grade gliomas”, Biochemical and Biophysical Research Communications, 501(3), 619, 627. (SCI)
  • Lin TC, Huang KW, Liu CW, Chang YC, Lin WM, Yang TY, Hsiao M*, 2018, “Leptin signaling axis associates with clinical prognosis and is multifunctional in regulating cancer progression”, Oncotarget, 9(24), 17210-17219. (SCI)
  • Chan MH, Pan YT, Chan YC, Hsiao M*, Chen CH, Sun L, Liu RS, 2018, “Nanobubble-embedded inorganic 808 nm excited-upconversion nanocomposites for tumorous multiple imaging and treatment”, Chemical Science, Feb 9; 9(12), 3141-3151. (SCI)
  • Chan YC, Chan MH, Chen C, Liu RS, Hsiao M*, Tsai DP, 2018, “Near-Infrared-Activated Fluorescence Resonance Energy Transfer-Based Nanocomposite to Sense MMP2-Overexpressing Oral Cancer Cells”, ACS Omega, 3(2), 1627-1634. (SCI)
  • Chan MH, Chen SP, Chen CW, Chan YC, Lin RJ, Tsai DP, Hsiao M*, Chung RJ, Chen X, Liu RS, 2018, “Single 808 nm laser treatment comprising photothermal and photodynamic therapies by using gold nanorod hybrid upconversion particles”, Journal of Physical Chemistry C, 122(4), 2402-2412. (SCI)
  • Yeh CN, Chang YC, Su Y, Hsu DS, Cheng CT, Wu RC, Chung YH, Chiang KC, Yeh TS, Lu ML, Liu CY, Chang PM, Chen MH, Huang CY, Hsiao M*, Chen MH, 2017, “Upregulation of MALT1 determines poor clinical outcomes in cholangiocarcinoma and shows therapeutic potential of regorafenib”, Oncotarget, 8(69), 113444-113459. (SCI)
  • Huang SP, Chang YC, Low QH, Wu ATH, Chen CL, Lin YF, Hsiao M*, 2017, “BICD1 expression, 1 as a potential biomarker for prognosis and predicting response to therapy in patients with glioblastomas”, Oncotarget, 8(69), 113766-113791. (SCI)
  • Chang YC, Chan YC, Chang MW, Lin YF, Yang CJ, Su CY, Huang MS, Wu AT, Hsiao M*, 2017, “Feedback regulation of ALDOA activates HIF-1α/MMP9 axis to promote lung cancer progression”, Cancer Letters, 403, 28-36. (SCI)
  • Chan YC, Hsiao M*, 2017, “Protease-activated nanomaterials for targeted cancer theranostics”, Nanomedicine, 12(18), 2153-2159. (SCI)
  • Chiou J, Su CY, Jan YH, Yang CJ, Huang MS, Yu YL, Hsiao M*, 2017, “Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma”, Scientific Reports, 7(1), 9830. (SCI)
  • Lin TC, Hsiao M*, 2017, “Ghrelin and cancer progression”, Biochimica et Biophysica Acta-Reviews on Cancer, 1868, 51-57. (SCI)
  • Chi LH, Chang YC, Chang WM, Chan YC, Tai CC, Leung KW, Chen CL, Wu ATH, Lai TC, Li YCJ Li, Hsiao M*., 2017, “Global proteomics-based Identification and validation of Thymosin Beta-4 2 X-Linked as a prognostic marker for head and neck squamous cell carcinoma”, Scientific Reports, 7(1), 9031. (SCI)
  • Hsiao YW, Lai TC, Lin YH, Su CY, Liao AT, Lin YF, Hsieh SC, Wu AT, Hsiao M*, 2017, “Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity”, Oncotarget, 8(48), 83495-83508. (SCI)
  • Chang YC, Su CY, Chen MH, Chen WS, Chen CL, Hsiao M*, 2017, “Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promotes colon cancer metastasis and is associated with poor prognosis”, Molecular Cancer, 16(1), 135. (SCI)
  • Chien MH, Lee WJ, Chang YC, Chang WM, Lai TC, Chan DV, Sharma R, Lin YF, Hsiao M*, 2017, “A Fas ligand (FasL)-fused humanized antibody against tumor-associated glycoprotein 72 (hcc49scFV-FasL) selectively exhibits the cytotoxic effect against oral cancer cells with a low FasL/Fas ratio”, Molecular Cancer Therapeutics, 16(6), 1102-1113. (SCI)
  • Chan MH, Pan YT, Lee IJ, Chen CW, Chan YC, Hsiao M*, Wang F, Sun L, Chen X, Liu RS, 2017, “Minimizing the heat effect of photodynamic therapy based on inorganic nanocomposites mediated by 808 nm near-infrared light”, Small, 13(21), 1700038. (SCI)
  • Chang YC, Chi LH, Chang MW, Su CY, Lin YF, Chen CL, Chen MH, Chang PM, Wu AT, Hsiao M*, 2017, “Glucose transporter 4 promotes head and neck cancer metastasis through TRIM24-DDX58 axis”, Journal of Hematology & Oncology, 10(1), 11. (SCI)
  • Chang WM, Lin YF, Su CY, Peng HY, Chang YC, Lai TC, Wu GH, Hsu YM, Chi LH, Hsiao JR, Chen CL, Chang JY, Shieh YS, Hsiao M*, Shiah SG, 2016, “Dysregulation of Runx2/Activin A axis upon miR376c downregulation promotes lymph node metastasis in head and neck squamous cell carcinoma.”, Cancer Research, 76(24),7140-7150. (SCI)
  • Chen CW, Chan YC, Hsiao M*, Liu RS, 2016, “Plasmon-enhanced photodynamic cancer therapy by upconversion nanoparticles conjugated with Au nanorods”, ACS Applied Materials & Interfaces, 8(47), 32108-32119. (SCI)
  • Wei L, Su YK, Lin CM, Chao TY, Huynh TT, Jan HJ, Whang-Peng J, Chiou JF, Wu AT, Hsiao M*, 2016, “Preclinical investigation of Ibrutinib, a Bruton’s kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes”, Oncotarget, Oct. 25;7(43), 69961-975. (SCI)
  • Su CY, Chang YC, Yang CJ, Huang MS, Hsiao M*, 2016, “The opposite prognostic effect of NDUFS1 and NDUFS8 forms a prognostic panel for non-small cell lung cancer by reflecting the oncojanus role of mitochondrial complex I”, Scientific Reports, Aug 12;6, 31357. (SCI)
  • Chan YC, Chen CW, Chan MH, Chang YC, Chang MW, Chi LH, Yu HM, Lin YF, Tsai DP, Liu RS, Hsiao M*, 2016, “MMP2-sensing up-conversion nanoparticle for fluorescence biosensing in head and neck cancer cells”, Biosensors & Bioelectronics, Jun 15;80:131-139. (SCI)
  • Chang YC, Su CY, Hsiao M*, 2016, “Therapeutic targeting of methylthioadenosine phosphorylase ”, Cancer Cell & Microenvironment, June;3:e1322. (Invited Review).
  • Hsu CY, Lin CH, Jan YH, Su CY, Yao YC, Cheng HC, Hsu TI, Wang PS, Su WP, Yang CJ, Huang MS, Calkins MJ, Hsiao M*, Lu PJ, 2016, “HIP1 is an Early-stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated EMT.”, American Journal of Respiratory and Critical Care Medicine, Apr 15;193(8):869-880. (SCI)
  • Lin TC, Su CY, Lai TC, Pan WA, Jan YH, Yeh CT, Chen CL, Ger LP, Chang HT, Yang CJ, Huang MS, Shyy JY, Tsai MD, Hsiao M*, 2016, “NIFK promotes cancer metastasis through Runx1-dependent repression of casein kinase 1α to activate Wnt/b-catenin signaling”, eLife, Mar 17;5:e11288. (SCI)
  • Lin TC, Liu YP, Chan YC, Su CY, Lin YF, Hsu SL, Yang CS, Hsiao M*, 2015, “Ghrelin promotes renal cell carcinoma metastasis via snail activation and is associated with poor prognosis”, The Journal of Pathology, 237(1), 50-61. Cite 3. (SCI)
  • Yang YF, Jan YH, Liu YP, Yang CJ, Su CY, Lin YF, Chang YC, Lai TC, Chiou J, Tsai HY, Lu J, Shen CN, Shew JY, Lu PJ, Huang MS, Hsiao M*, 2014, “Squalene Synthase Induces TNFR1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis.”, American Journal of Respiratory and Critical Care Medicine, 190(6), 675-687. Cite 2. (SCI)
  • Liu YP, Liao WC, Ger LP, Chen JC, Hsu TI, Lee YC, Chang HT, Chen YC, Jan YH, Lee KH, Zeng YH, Hsiao M*, Lu PJ, 2013, “Carboxyl-terminal modulator protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast cancer.”, Cancer Res, 73(20), 6194-6205. Cite 5. (SCI)
  • Tsai HY, Yang YF, Wu AT, Yang CJ, Liu YP, Jan YH, Lee CH, Hsiao YW, Yeh CT, Shen CN, Lu PJ, Huang MS, Hsiao M*, 2013, “Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78.”, Oncogene, 32(41), 4921-4931. Cite 13. (SCI)
  • Liu YP, Hsiao M*, 2013, “Exercise-induced SPARC prevents tumorigenesis of colon cancer”, Gut, 62(6), 810-811. Cite 2. (SCI)
  • Liu CH, Chen TC, Chau GY, Jan YH, Chen CH, Hsu CN, Lin KT, Juang YL, Lu PJ, Cheng HC, Chen MH, Chang CF, Ting YS, Kao CY, Hsiao M*, Huang CY, 2013, “An analysis of protein-protein interactions in cross-talk pathways reveals CRKL as a novel prognostic marker in hepatocellular carcinoma.”, Mol Cell Proteomics, 12(5), 1335-1349. Cite 12. (SCI)
  • Cheng LC, Chen HM, Lai TC, Liu RS, Sung JC, Hsiao M*, Chen CH, Her LJ, Tsai DP, 2013, “Targeting polymeric fluorescent nanodiamond-gold/silver multi-functional nanoparticles as a light-transforming hyperthermia reagent for cancer cell”, Nanoscale, May 7;5(9):3931-40. Cite 14. (SCI)
  • Liu YP, Yang CJ, Huang MS, Yeh CT, Wu AT, Lee YC, Lai TC, Lee CH, Hsiao YW, Lu J, Shen CN, Lu PJ, Hsiao M*, 2013, “Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling”, Cancer Res, 73(1), 406-416. Cite 43. (SCI)
  • Jan YH, Tsai HY, Yang CJ, Huang MS, Yang YF, Lai TC, Lee CH, Jeng YM, Huang CY, Su JL, Chuang YJ, Hsiao M*, 2012, “Adenylate Kinase-4 Is a Marker of Poor Clinical Outcomes That Promotes Metastasis of Lung Cancer by Downregulating the Transcription Factor ATF3.”, Cancer Res, 72(19), 5119-5129. Cite 14. (SCI)
  • Lin FC, Liu YP, Lai CH, Shan YS, Cheng HC, Hsu PI, Lee CH, Lee YC, Wang HY, Wang CH, Cheng JQ, Hsiao M*, Lu PJ, 2012, “RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells.”, Oncogene, 31(39), 4302-4316. Cite 20. (SCI)
  • Tsai WC, Hsu SD, Hsu CS, Lai TC, Chen SJ, Shen R, Huang Y, Chen HC, Lee CH, Tsai TF, Hsu MT, Wu JC, Huang HD, Shiao MS, Hsiao M*, Tsou AP, 2012, “MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis.”, J Clin Invest, 122(8), 2884-2897. Cite 214. (SCI)
  • Cheng LC, Huang JH, Chen HM, lai TC, Liu RS, Hsiao M*, Chen CH, Her LJ, Tsai DP, 2012, “Seedless, silver-induced synthesis of star-shaped gold/silver bimetallic nanoparticles as high efficiency photothermal therapy reagent”, J Mater Chem, 22(5), 2244-2253. Cite 50.
  • Huang JH, Lai TC, Cheng LC, Liu RS, Lee CH, Hsiao M*, Chen CH, Her LJ, Tsai DP, 2011, “Modulating cell-uptake behavior of Au-based nanomaterials via quantitative biomolecule modification”, J Mater Chem, 21, 14821-14829. Cite 4.
  • Hua KT, Tan CT, Johansson G, Lee JM, Yang PW, Lu HY, Chen CK, Su JL, Chen PB, Wu YL, Chi CC, Kao HJ, Shih HJ, Chen MW, Chien MH, Chen PS, Lee WJ, Cheng TY, Rosenberger G, Chai CY, Yang CJ, Huang MS, Lai TC, Chou TY, Hsiao M*, Kuo ML, 2011, “N-alpha-Acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity”, Cancer Cell, 19(2), 218-231. Cited 36. (SCI)
  • Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huang MS, Hsiao M*, Kuo ML, 2010, “H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM.”, Cancer Res, 70(20), 7830-7840. Cite 108. (SCI)
  • Cheng WH, Lu PJ, Ho WY, Tung CS, Cheng PW, Hsiao M*, Tseng CJ, 2010, “Angiotensin II Inhibits Neuronal Nitric Oxide Synthase Activation Through the ERK1/2-RSK Signaling Pathway to Modulate Central Control of Blood Pressure.”, Circ Res, Mar 5;106(4):788-95. Cite 29. (SCI)
  • Tsai WC, Hsu PW, Lai TC, Chau GY, Lin CW, Chen CM, Lin CD, Liao YL, Wang JL, Chau YP, Hsu MT, Hsiao M*, Huang HD, Tsou AP, 2009, “MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma.”, Hepatology, May; 49(5), 1571-1582. Cite 261. (SCI)
  • Liao YL, Sun YM, Chau GY, Chau YP, Lai TC, Wang JL, Horng JT, Hsiao M*, Tsou AP, 2008, “Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma.”, Oncogene, Sep 18;27(42):5578-5589. Cite 78. (SCI)