Wong, Chi-Huey

WongCH6x7Distinguished Research Fellow


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EDUCATION AND POSITIONS HELD:

  • Ph.D. in Chemistry, MIT, 1979-1982
  • Postdoctoral Fellow, Harvard University, 1982–1983
  • Assistant Professor through Professor of Chemistry, Texas A&M University, 1983–1989
  • Professor and Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 1989–2006.
  • Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 1996–2006.
  • Head, Frontier Research Program on Glycotechnology, Institute of Physical and Chemical Research (RIKEN), Japan, 1991–1999.
  • Distinguished Research Fellow, The Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2003–present
  • Director, The Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2003–2006.
  • President, Academia Sinica, Taipei, Taiwan, 2006-2016.
  • Joint Appointment: The Scripps Research Institute and National Taiwan University

HONORS:

  • Searle Scholar Award in Biomedical Sciences, 1985
  • Presidential Young Investigator in Chemistry, 1986
  • The IUPAC International Carbohydrate Award, 1994
  • Elected Member of Academia Sinica, Taipei, 1994
  • Elected Member of the American Academy of Arts and Sciences, 1996
  • American Chemical Society Harrison Howe Award in Chemistry, 1998
  • American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry, 1999
  • The International Enzyme Engineering Award, 1999
  • Presidential Green Chemistry Award, USA, 2000
  • Elected Member of the National Academy of Sciences, USA 2002
  • American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 2005
  • The F. A. Cotton Medal for Excellence in Chemical Research, 2008
  • Editor-in-Chief, Bioorganic & Medicinal Chemistry, 1993–2010
  • Elected Associate Member of the European Molecular Biology Organization (EMBO), 2010
  • The American Chemical Society Arthur C. Cope Award, 2012
  • Nikkei Asia Prize for Science, Technology and Innovation, 2012
  • The Wolf Prize in Chemistry, 2014
  • Elected Fellow of the U.S. National Academy of Inventors, 2014
  • The Royal Society of Chemistry Robert Robinson Award, UK, 2015

RESEARCH INTERESTS:

Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting proteins and RNA has been performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules. Development of both synthetic and bioorganic strategies is also paramount to our research. Programmable one-pot reactions are being developed for the synthesis of complex oligosaccharides and glycoarrays and complement new strategies for the assembly of glycoproteins, vaccines and other biologically active molecules to tackle major problems in biology, especially associated with cancer, infectious diseases and immune response.

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SELECTED PUBLICATIONS:

  • W.-S. Wu, W.-C. Cheng, T.-R. Cheng, C.-H. Wong, 2018, “Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.”, Journal of the American Chemical Society, 140(8), 2752-2755. (SCI)
  • P.-W. Lo, J.-J. Shie, C.-H. Chen, C.-Y. Wu, T.-L. Hsu, C.-H. Wong, 2018, “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(28), 7302-7307. (SCI)
  • V. S. Shivatare, S. S. Shivatare, C.-C. Lee, C.-H. Liang, K.-S. Liao, Y.-Y. Cheng, G. Saidachary, C.-Y. Wu, N.-H. Lin, P. D. Kwong, D. Burton, C.-Y. Wu, C.-H. Wong, 2018, “Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.”, Journal of the American Chemical Society, 140(15), 5202-5210. (SCI)
  • Y.-W. Huang, H.-I. Yang, Y.-T. Wu, T.-L. Hsu, T.-W. Lin, J. Kelly, C.-H. Wong, 2017, “Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency.”, Journal of the American Chemical Society, 139(37), 12947-12955. (SCI)
  • T. H. Tseng, T.-W. Lin, C.-Y. Chen, C.-H. Chen, J.-L. Lin, T.-L. Hsu, C.-H. Wong, 2017, “Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases.”, Journal of the American Chemical Society, 139(28), 9431-9434. (SCI)
  • L. Krasnova and C.-H. Wong, 2016, “Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis”, ANNUAL REVIEW OF BIOCHEMISTRY, 85, 599-630. (SCI)
  • S. Danishefsky, Y.-K. Shue, M. Chang, C.-H. Wong, 2015, “Development of Globo-H Cancer Vaccine”, ACCOUNTS OF CHEMICAL RESEARCH, 48(3), 643-652. (SCI)
  • J.-J. Shie, Y.-C. Liu, Y.−M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, 2014, “An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation”, J. Am. Chem. Soc., 136(28), 9953-9961. (SCI)
  • Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang, S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2014, “Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(7), 2482-2487. (SCI)
  • J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu, S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma and C.-H. Wong, 2014, “Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(7), 2476-2481. (SCI)
  • Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2517-2522. (SCI)
  • C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2013, “Fucosyltransferase 8 as a Functional Regulator of Non-Small Cell Lung Cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(2), 630-635. (SCI)
  • C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong and C. Ma, 2012, “Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(17), 6496-6501. (SCI)
  • K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, T.-A. Chao, Y.-F. Lin, S.-H. Wu, C.-H. Wong and C.-Y. Wu, 2011, “Efficient and Stereoselective Synthesis of α(2→9) Oligosialic Acids Up to Dodecamer”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(40), 9391-9395. (SCI)
  • Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, 2011, “Sialylation and Fucosylation of Epidermal Growth Factor Receptor Suppress its Dimerization and Activation in Lung Cancer Cells”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(28), 11332-11337. (SCI)
  • Y.-F. Shen, Y.-H. Chen, S.-Y. Chu, M.-I. Lin, H.-T. Hsu, P.-Y. Wu, C.-J. Wu, H.-W. Liu, F.-Y. Lin, G. Lin, P.-H. Hsu, A.-S. Yang, Y.-S. E. Cheng, Y.-T. Wu, C.-H. Wong, and M.-D. Tsai, 2011, “E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(40), 16515-16520. (SCI)
  • E. K. Culyba, J. L. Price, S. R. Hanson, A. Dhar, C.‐H. Wong, M. Gruebele, E. T. Powers and J. W. Kelly, 2011, “Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns”, Science, 331(6017), 571-575. (SCI)
  • C.-H. Hsu, S.-C. Hung, C.-Y. Wu, and C.-H. Wong, 2011, “Toward Automated Oligosaccharide Synthesis”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(50), 11872-11923. (SCI)
  • S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides Through Phosphonate Chemistry”, J. Am. Chem. Soc, 132(38),13371-13380. (SCI)
  • S. R. Hanson, E. K. Culyba, T. L. Hsu, C.-H. Wong, J. W. Kelly, E. T. Powers, 2009, “The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(9), 3131-3136. (SCI)
  • C. Bennett, S. Dean, R. Payne, S. Ficht, A. Brik and C.-H. Wong, 2008, “Sugar-assisted Glycopeptide Ligation with Complex Oligosaccharides: Scope and Limitations”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(36), 11945-11952. (SCI)
  • T. L. Hsu, S. R. Hanson, K. Kishikawa, S. K. Wang, M. Sawa and C. H. Wong, 2007, “Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 2614-2619. (SCI)
  • M. Sawa, T.-L. Hsu, T. Itoh, M. Sugiyama, S. R. Hanson, P. K. Vogt, and C.-H. Wong, 2006, “Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(33), 12371-12376. (SCI)
  • O. Blixt, S. Head, T. Mondala, C. Scanlan, M.E. Huflejt, R. Alvarez, M.C. Bryan, F. Fazio, D. Calarese, J. Stevens, N. Razi, I. van Die, D. Burton, I.A. Wilson, R. Cummings, N. Bovin, C.-H. Wong, J.C. Paulson, 2004, “Printed covalent glycan array for ligand profiling of diverse glycan binding proteins”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 17033-17038. (SCI)
  • K. M. Koeller, C. H. Wong, 2001, “Enzymes for chemical synthesis”, NATURE, 409, 232-240. (SCI)
  • A. Heine, G. DeSantis, J. G. Luz, M. Mitchell, C. H. Wong and I. A. Wilson, 2001, “Observation of covalent intermediates in an enzyme mechanism at atomic resolution”, SCIENCE, 294, 369-374. (SCI)
  • P. Sears, C. H. Wong, 2001, “Toward automated synthesis of oligosaccharides and glycoproteins”, SCIENCE, 291, 2344-2350. (SCI)