Wong, Chi-Huey

WongCH6x7Distinguished Professor


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Telephone: +886-2-27899929

 

 

 

EDUCATION AND POSITIONS HELD:

  • Ph.D. in Chemistry, MIT, 1979-1982
  • Postdoctoral Fellow, Harvard University, 1982–1983
  • Assistant Professor through Professor of Chemistry, Texas A&M University, 1983–1989
  • Professor and Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 1989–2006.
  • Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 1996–2006.
  • Head, Frontier Research Program on Glycotechnology, Institute of Physical and Chemical Research (RIKEN), Japan, 1991–1999.
  • Distinguished Professor, Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2003–present
  • Director, The Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2003–2006.
  • President, Academia Sinica, Taipei, Taiwan, 2006-2016.
  • Scripps Family Chair Professor, Department of Chemistry, The Scripps Research Institute, La Jolla, California, 2019-present

HONORS:

  • Searle Scholar Award in Biomedical Sciences, 1985
  • Presidential Young Investigator in Chemistry, 1986
  • The IUPAC International Carbohydrate Award, 1994
  • Elected Member of Academia Sinica, Taipei, 1994
  • Elected Member of the American Academy of Arts and Sciences, 1996
  • American Chemical Society Harrison Howe Award in Chemistry, 1998
  • American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry, 1999
  • The International Enzyme Engineering Award, 1999
  • Presidential Green Chemistry Award, USA, 2000
  • Elected Member of the National Academy of Sciences, USA 2002
  • American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 2005
  • The F. A. Cotton Medal for Excellence in Chemical Research, 2008
  • Editor-in-Chief, Bioorganic & Medicinal Chemistry, 1993–2010
  • Elected Associate Member of the European Molecular Biology Organization (EMBO), 2010
  • The American Chemical Society Arthur C. Cope Award, 2012
  • Nikkei Asia Prize for Science, Technology and Innovation, 2012
  • The Wolf Prize in Chemistry, 2014
  • Elected Fellow of the U.S. National Academy of Inventors, 2014
  • The Royal Society of Chemistry Robert Robinson Award, UK, 2015

RESEARCH INTERESTS:

Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Current interest is centered on the development of discovery tools for understanding the role of biological glycosylation in cancer progression, bacterial and viral infection, neurodegenerative disorder and immune response. Programmable one-pot synthesis as well as chemo-enzymatic synthesis of oligosaccharides and homogeneous glycoproteins, and design of glycan microarrays and glycosylation probes are among the tools being developed for the study of cell-surface glycoconjugates. The ultimate goal of our research is to identify novel glycan targets for therapeutic development, including the development of carbohydrate-based vaccines, homogeneous antibodies with optimized effector functions, and inhibitors of key enzymes involved in the biosynthesis of glycan targets.

Our main focus is to develop new tools for understanding the role of biological glycosylation in the development of diseases with an ultimate goal of developing new therapeutic strategies to combat them.

cell-surface-1-CH-Wong

SELECTED PUBLICATIONS: