Chang, Chi-Fon

CFChang6x7Senior Research specialist

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Telephone: +886-2-27871236



  • Ph.D. , Biophysics, The Ohio State University ,1997
  • Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica , 1997-1999
  • NMR Supporting Team Manager, Institute of Biomedical Sciences, Academia Sinica,1999-2002
  • NMR Facility Manager, High-Field Biomacromolecular Solution NMR Core Facility, Academia Sinica ,2002-present
  • Associate Research Specialist, Genomics Research Center, Academia Sinica, 2004-2010
  • Senior Research Specialist, Genomics Research Center, Academia Sinica, 2010-present


GRC NMR Facility

As a research specialist, I am responsible for the daily operation on NMR facility and assist researchers carrying out NMR related researches. I have dedicated myself to provide competent and efficient routine service, as well as all aspects of advance technical support on NMR spectroscopy. The duty of my job includes: keeping track of machine time usage; supervising the facility staff members; training users on using NMR spectrometers; developing and implementing new NMR experiments; assisting users setting up advanced NMR experiments; advising users on specific NMR experiments and applications; and providing technical consultation. My expertise is using biophysical methods, especially the NMR approach, to obtain structural and functional information for biomolecules.


  • Huang YP, Cho CC, Chang CF, Hsu CH, 2016, “NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV).”, Biomolecular NMR assignments, 10(2), 245-248. (SCI)
  • Yi-Chuan Li, Chung-ke Chang, Chi-Fon Chang, Ya-Hsin Cheng, Pei-Ju Fang, Tsunai Yu, Sheng-Chia Chen, Chwan-Deng Hsiao*, Tai-huang Huang*, 2014, “Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element ”, NUCLEIC ACIDS RESEARCH, 42(13), 8777-8788. (SCI)
  • Ming-Yuan Su, Chung-I Chang and Chi-Fon Chang* , 2013, “1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD ”, Biomolecular NMR Assignments, 7(2), 141-143. (SCI)
  • Ming-Yuan Su, Chiao-I Kuo, Chi-Fon Chang*, Chung-I Chang*, 2013, “Three-Dimensional Structure of Human NLRP10/PYNOD Pyrin Domain Reveals a Homotypic Interaction Site Distinct from Its Mouse Homologue”, PLoS One, 8(7), e67843. (SCI)
  • Ching-Yu Chou, Minglee Chu, Chi-Fon Chang, Tai-huang Huang*, 2012, “A compact high-speed mechanical sample shuttle for field-dependent high-resolution solution NMR ”, JOURNAL OF MAGNETIC RESONANCE, 214, 302-308. (SCI)
  • M. T. Naik, C. F. Chang, I. C. Kuo, C. C. H. Kung, K. Y. Chua and T.-H Huang, 2008, “Roles of structure and structural dynamics in the antibody recognition of the allergen proteins: A NMR study on Blomia tropicalis major allergen”, Structure, 16, 125-136. (SCI)
  • C. F. Chang, H. T. Chou, Y. J. Lin, S. J. Lee, J. L. Chuang, D. T. Chuang and T. H. Huang, 2006, “Structure of the subunit binding domain and dynamics of the di-domain region from the core of human branched chain alpha-ketoacid dehydrogenase complex”, J Biol Chem, 281, 28345-28353. (SCI)
  • C. F. Chang, H. T. Chou, J. L. Chuang, D. T. Chuang and T. H. Huang, 2002, “Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex”, J Biol Chem, 277, 15865-15873. (SCI)
  • C. F. Chang, M. H. Zehfus, 1998, “Effects of backbone modification on helical peptides: the reduced carbonyl modification”, Biopolymers, 46, 181-193. (SCI)
  • C. F. Chang, C. Chen, Y. C. Chen, K. Hom, R. F. Huang and T. H. Huang, 1998, “The solution structure of a cytotoxic ribonuclease from the oocytes of Rana catesbeiana (bullfrog)”, J Mol Biol, 283, 231-244. (SCI)