Research Fellow / Institute of Biomedical Sciences, Academia Sinica


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EDUCATION AND POSITIONS HELD:

  • Ph.D., Microbiology and Immunology, University of California, Los Angeles, USA (1992)
  • Senior Scientist, Wyeth-Ayerst Research, Pennsylvania, USA (1993-1994)
  • Associate Investigator, Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan (1994-1998)
  • Assistant Research Fellow, Institute of Biomedical Sciences (IBMS), Academia Sinica (AS), Taipei, Taiwan (1998-2002)
  • Associate Research Fellow, IBMS, AS, Taipei, Taiwan (2002-present)

HONORS:

  • National Science Council Research Award, 1996-2002
  • National Defense Medical Center Research Award, 1997
  • Young Investigator Award, Academia Sinica, 2000
  • National Science Council Distinguished Research Award, 2003-2004

RESEARCH INTERESTS:

Virus-Host Interactions

Our laboratory centers on two reemerging flaviviruses in Taiwan, dengue virus (DEN) and Japanese encephalitis virus (JEV). JEV is transmitted to humans by infected mosquitoes and causes acute encephalitis with high fatality rates. DEN generally causes a mild febrile illness, dengue fever and infrequently a much more severe disease, dengue hemorrhagic fever/dengue shock syndrome. Research interests in this laboratory are the molecular biology, virology, pathogenesis, immunology and vaccine development of these viruses. The goal is to understand the virus-host interactions in flavivirus infection. Current projects include: 1.) multifaceted interactions between type I interferon (IFN) and JEV: the molecular mechanisms adopted by JEV to induce IFN production and to block the IFN-induced Jak-Stat signaling. 2.) Cytopathic effect (CPE) mechanism related: the role played by PI-3K/Akt pathway in virus infection; and the involvement of individual viral proteins in virus-induced CPE. 3.) Immunity related: the antiviral mechanism of IFN on DEN infection; and DNA vaccine against JEV/DEN infection. 4.) Anti-viral related: collaboration with other institutes to test the potential antiviral chemicals.