Hsieh, Shie-Liang

SLHsieh2Distinguished Research Fellow

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Telephone: +886-2-27871245
[ CV ]




  • M.D., National Yang-Ming University, 1984
  • D.Phil., University of Oxford, UK, 1992
  • Postdoctoral fellow, Stanford University, 1993
  • Director, Institute of Clinical Medicine, Natl. Yang-Ming Univ., Taipei,Taiwan, 2010-2013
  • Distinguished Professor, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan, 2007-2013
  • Professor, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan ,2001-2013
  • Director, Immunology Research Center, Natl. Yang-Ming Univ., Taiwan, 2000-2013
  • Director, Immunology Research Center, Taipei Veterans’ General Hospital, Taiwan, 2005-present
  • Co-appointed Senior Investigator, National Health Research Center, Taipei, Taiwan ,2004-present
  • Co-appointed Senior Investigator, Academia Sinica, Taipei, Taiwan, 2004-present
  • Adjunct Research Fellow, Academia Sinica, Taipei, Taiwan, 2009-2013
  • Distinguished Research Fellow, Academia Sinica, Taipei, Taiwan, 2013-present
  • Adjunct Distinguished Professor, Institute of Clinical Medicine, Natl. Yang-Ming Univ., Taipei, Taiwan ,2013-present
  • Adjunct Professor, National Taiwan University ,2014-present


  • 2013    8th Session TienTe Lee Award
  • 2012    National Chair Professor Award
  • 2010    Outstanding Researcher Award from the National Science Council
  • 2009    Long-Term Award from Acer Foundation
  • 2009    Academic Achievement Award, Ministry of Education
  • 2009    Tsungming Tu Award, Taiwan Medical Society
  • 2008    Outstanding research Achievement to National Health, “Ming-Ning Wang Memorial Foundation” (2008)
  • 2003    Outstanding Alumni, National Yang-Ming University 
  • 2003    Outstanding Researcher Award from the National Science Council
  • 1999    Outstanding Researcher Award from the National Science Council 
  • 1992    Irvington Medial Foundation post-doctoral fellowship ‘Robert Wood Johnson Fellow
  • 1989    Oversea Research Scholarship (ORS) from the University of Oxford
  • 1989    Oversea PhD studentship from the Ministry of Education, Taiwan


Innate Immunity and GlycoMedicine

Except from congenital defects, most of human diseases are resulted from exaggerated acute or chronic inflammatory reactions. Initiation of inflammatory reaction is via the activation of innate immunity receptors on NK cells, monocytes, macrophages, PMNs and platelets by either infectious agents, foreign antigens or aberrant expressed endogenous antigens. Thus, understanding the molecular mechanisms of innate immune responses to exogenous and endogenous antigens would be able to develop novel strategy to treat numerous human diseases such as infection, autoimmunity, and allergic reactions.

It is still unclear how innate immunity receptors recognize the distinct foreign glycans expressed on pathogens (PAMPs) as well as the aberrant expressed endogenous glycans (DAMPs). Recently, we have developed the innate immunity receptor-ELISA (IIR-EIA) platform and identify members of C-type lectins as the pattern recognition receptors to dengue virus (CLEC5A), allergens, pathogens and endogenous ligands. We have shown that blockade of CLEC5A is able to prevent DV-induced lethality and JEV-induced neuroinflammation in animal models. Moreover, members of Syk-coupled CLRs are crucial to control inflammasome activations, and have synergistic effects of members of NLRs and TLRs. We are systemically identify the functions of novel C-type lectins using gene-deficient mice, blocking antibodies and siRNAs to explore their functions, with the hope to identify the potential targets to treat human diseases.

Initiation of_inflammation


  • Chen ST, Chen JW, Wu WC, Chou TY, Yang CY, Hsieh SL*., to appear, “CLEC5A is a Critical Receptor in Innate Immunity against Listeria Infection.”, NATURE COMMUNICATIONS. (SCI)
  • Lai JH, Lin YL, Hsieh SL* , 2017, “Pharmacological intervention for dengue virus infection”, BIOCHEMICAL PHARMACOLOGY, 129, 14-25. (SCI)
  • Teng, O, Chen, ST, Hsu TL, Sia SF, Cole S, Valkenburg SA, Hsu TY, Zheng JT, Tu W, Bruzzone R, Peiris JSM, Hsieh SL*, Yen HL*, 2017, “CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo.”, JOURNAL OF VIROLOGY, 91, e01813. (SCI)
  • Shie-Liang Hsieh*, Lin Wan-Wan, 2017, “Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions”, Journal of Biomedical Science, 24(1), 39. (SCI)
  • Shie-Liang Hsieh, 2016, “Chapter 3: The DAP12-Associated Myeloid C-Type Lectin 5A (CLEC5A).”, editor(s): Sho Yamasaki, C-type Lectin Receptors in Immunity, pp. 35-48, Japan: Springer Japan.
  • Tung YL, Wu MF, Wang GJ*, Hsieh SL*, 2014, “Nanostructured electrochemical biosensor for the detection of the weak binding between the dengue virus and the CLEC5A receptor.”, Nanomedicine-Nanotechnology Biology and Medicine, 10(6), 1335-1341. (SCI)
  • Chen DY, Yao L, Chen YM, Lin CC, Huang KC, Chen ST, Lan JL*, Hsieh SL*, 2014, “A Potential Role of Myeloid DAP12-Associating Lectin (MDL)-1 in the Regulation of Inflammation in Rheumatoid Arthritis Patients.”, PLoS One, 9(1), e86105. (SCI)
  • Yang CY, Chen JB, Tsai TF, Tsai YC, Tsai CY, Liang PH, Hsu TL, Wu CY, Netea MG, Wong CH, Hsieh SL*, 2013, “CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver.”, PLoS One, 8(6), e65070. (SCI)
  • Wu MF, Chen ST, Hsieh SL*, 2013, “Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets.”, JOURNAL OF BIOMEDICAL SCIENCE, 20, 36. (SCI)
  • Wu MF, Chen ST, Yang AH, Lin WW, Lin YL, Chen NJ, Tsai IS, Li L, Hsieh SL*, 2013, “CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages”, BLOOD, 121(1), 95-106. (SCI)
  • Chen ST, Liu RS, Wu MF, Lin YL, Chen SY, Tan DT, Chou TY, Tsai IS, Li L, Hsieh SL*, 2012, “CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality.”, PLoS Pathogens, 8(4), e1002655. (SCI)
  • Tai SK, Chang HC, Lan KL, Lee CT, Yang CY, Chen NJ, Chou TY, Tarng DC, Hsieh SL*, 2012, “Decoy receptor 3 enhances tumor progression via induction of tumor-associated macrophages.”, JOURNAL OF IMMUNOLOGY, 188(5), 2464-2471. (SCI)
  • Chen ST , Lin YL , Huang MT , Wu MF , Hsieh SL*, 2011, “Targeting C-type lectin for the treatment of flaviviral infections.”, editor(s): Albert M. Wu, The Molecular Immunology of Complex Carbohydrates-3, pp. 769-776, USA: Springer.
  • Lin WW, Hsieh SL*, 2011, “Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer.”, BIOCHEMICAL PHARMACOLOGY, 81(7), 838-847. (SCI)
  • Lee RT, Hsu TL, Huang SK, Hsieh SL, Wong CH, Lee YC, 2011, “Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities.”, GLYCOBIOLOGY, 21(4), 512-520. (SCI)
  • Hsu TL, Cheng SC, Yang WB, Chin SW, Chen BH, Huang MT, Hsieh SL*, Wong CH*, 2009, “Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(50), 34479-34489. (SCI)
  • Chen CY, Yang KY, Chen MY, Chen HY, Lin MT, Lee YC, Perng RP, Hsieh SL, Yang PC, Chou TY, 2009, “Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome.”, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180(8), 751-760. (SCI)
  • Wu MF, Yang CY, Lin TL, Wang JT, Yang FL, Wu SH, Hu BS, Chou TY, Tsai MD, Lin CH, Hsieh SL*, 2009, “Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling.”, INFECTION AND IMMUNITY, 77(2), 615-621. (SCI)
  • How CK, Chern CH, Wu MF, Wang LM, Huang CI, Lee CH, Hsieh SL*, 2009, “Expression of the triggering receptor expressed on myeloid cells-1 mRNA in a heterogeneous infected population”, INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 63(1):126-33. (SCI)
  • Tsai CM, Chiu YK, Hsu TL, Lin IY, Hsieh SL, Lin KI, 2008, “Galectin-1 promotes immunoglobulin production during plasma cell differentiation.”, JOURNAL OF IMMUNOLOGY, 181(7), 4570-4579. (SCI)
  • Chang PM, Chen PM, Hsieh SL, Tzeng CH, Liu JH, Chiou TJ, Wang WS, Yen CC, Gau JP, Yang MH, 2008, “Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome.”, INTERNATIONAL JOURNAL OF ONCOLOGY, 33(3), 549-554. (SCI)
  • S. L. Hsieh*, 2008, “Decoy Receptor 3 (DcR3): A Pleiotropic Immunomodulator.”, BLOOD, 112(3), 916-917. (SCI)
  • Chang YC, Chen TC, Lee CT, Yang CY, Wang HW, Wang CC, Hsieh SL*, 2008, “Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3.”, BLOOD, 111(10), 5054-5063. (SCI)
  • Lee CS, Hu CY, Tsai HF, Wu CS, Hsieh SL, Liu LC, Hsu PN, 2008, “Elevated serum decoy receptor 3 with enhanced T cell activation in systemic lupus erythematosus.”, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 151(3), 383-390. (SCI)
  • Wang SK, Liang PH, Astronomo RD, Hsu TL, Hsieh SL, Burton DR, Wong CH, 2008, “Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN.”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(10), 3690-3695. (SCI)
  • You RI, Chang YC, Chen PM, Wang WS, Hsu TL, Yang CY, Lee CT, Hsieh SL*, 2008, “Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3).”, BLOOD, 111(3), 1480-1488. (SCI)
  • Chen ST, Lin YL, Huang MT, Wu MF, Cheng SC, Lei HY, Lee CK, Chiou TW, Wong CH, Hsieh SL*, 2008, “CLEC5A is critical for dengue-virus-induced lethal disease.”, NATURE, 453(7195):672-6. (SCI)
  • Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL*, Fu WM*, 2007, “Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice”, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(4):2346-54. (SCI)
  • You RI, Chen MC, Wang HW, Chou YC, Lin CH, Hsieh SL*, 2006, “Inhibition of Lymphotoxin-{beta} Receptor-Mediated Cell Death by Survivin-{Delta}Ex3”, CANCER RESEARCH, 66(6):3051-61. (SCI)
  • Su WB, Chang YH, Lin WW, Hsieh SL*, 2006, “Differential regulation of interleukin-8 gene transcription by deathreceptor 3 (DR3) and type I TNF receptor (TNFRI)”, EXPERIMENTAL CELL RESEARCH, 312(3):266-77. (SCI)
  • Chang YC, Chan YH, Jackson D. G., Hsieh SL*, 2006, “The glycosaminoglycan-binding domain of decoy receptor 3 is essential forinduction of monocyte adhesion”, JOURNAL OF IMMUNOLOGY, 176(1):173-80. (SCI)
  • Wang PH, Lee WL, Juang CM, Yang YH, Lo WH, Lai CR, Hsieh SL, Yuan CC, 2005, “Altered mRNA expressions of sialyltransferases in ovarian cancer”, GYNECOLOGIC ONCOLOGY, 99(3):631-9. (SCI)
  • Hsu TL, Wu YY, Chang YC, Yang CY, Lai MZ, Su WB, Hsieh SL*, 2005, “Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from aT1 and T2 doubly transgenic non-obese diabetic mouse model”, JOURNAL OF AUTOIMMUNITY, 25(3):181-92. (SCI)
  • Hsu TL, Wu YY, Chang YC, Yang CY, Lai MZ, Su WB, Hsieh SL*, 2005, “Attenuation of Th1 response in decoy receptor 3 transgenic mice”, JOURNAL OF IMMUNOLOGY, 175(8):5135-45. (SCI)
  • Yang CR, Hsieh SL, Ho FM, Lin WW, 2005, “Decoy receptor 3 increases monocyte adhesion to endothelial cells viaNF-kappa B-dependent up-regulation of intercellular adhesion molecule-1”, JOURNAL OF IMMUNOLOGY, 174(3):1647-56. (SCI)
  • Chang YH, Chao Y, Hsieh SL, Lin WW, 2004, “Mechanism of LIGHT/interferon-gamma-induced cell death in HT-29 cell”, JOURNAL OF CELLULAR BIOCHEMISTRY, 93(6):1188-202. (SCI)
  • Wu YY, Chang YC, Hsu TL, Hsieh SL, Lai MZ, 2004, “Sensitization of cells to TRAIL-induced apoptosis by decoy receptor 3.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(42):44211-8. (SCI)
  • Yang CR, Wang JH, Hsieh SL, Wang SM, Hsu TL, Lin WW, 2004, “Decoy receptor 3 (DcR3) induces osteoclast formation frommonocyte/macrophage lineage precursor cells”, CELL DEATH AND DIFFERENTIATION, 11(1):97-107. (SCI)
  • Chen CC, Yang YH, Lin YT, Hsieh SL, Chiang BL, 2004, “Soluble decoy receptor 3: increased levels in atopic patients”, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 114(1):195-7. (SCI)
  • Sung HH, Juang JH, Lin YC, Kuo CH, Hung JT, Chen A, Chang DM, Chang SY, Hsieh SL, Sytwu HK, 2004, “Transgenic expression of decoy receptor 3 protects islets from spontaneousand chemical-induced autoimmune destruction in nonobese diabetic mice”, JOURNAL OF EXPERIMENTAL MEDICINE, 199(8):1143-51. (SCI)
  • Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH, 2004, “Isolation of multipotent mesenchymal stem cells from umbilical cord blood.”, BLOOD, 103(5):1669-75. (SCI)
  • Chang YC, Hsu TL, Lin HH, Chio CC, Chiu AW, Chen NJ, Lin CH, Hsieh SL*, 2004, “Modulation of macrophage differentiation and activation by decoy receptor 3”, JOURNAL OF LEUKOCYTE BIOLOGY, 75(3):486-94. (SCI)
  • Wu SF, Liu TM, Lin YC, Sytwu HK, Juan HF, Chen ST, Shen KL, Hsi SC, Hsieh SL*, 2004, “Immunomodulatory effect of decoy receptor 3 on the differentiation andfunction of bone marrow-derived dendritic cells in nonobese diabetic mice”, JOURNAL OF LEUKOCYTE BIOLOGY, 75(2):293-306. (SCI)
  • Yang CR, Hsieh SL, Teng CM, Ho FM, Su WL, Lin WW, 2004, “Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, acytokine belonging to tumor necrosis factor superfamily and exhibitin”, CANCER RESEARCH, 64(3):1122-9. (SCI)
  • Hsu MJ, Lin WW, Tsao WC, Chang YC, Hsu TL, Chiu AW, Chio CC, Hsieh SL*, 2004, “Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3”, EXPERIMENTAL CELL RESEARCH, 292(2):241-51. (SCI)
  • Chen MC, Hwang MJ, Chou YC, Chen WH, Cheng G, Nakano H., Luh TY, Mai SC, Hsieh SL*, 2003, “The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death”, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(18):16073-81. (SCI)
  • Chang YH, Hsieh SL, Chen MC, Lin WW, 2002, “Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation”, EXPERIMENTAL CELL RESEARCH, 278(2):166-74. (SCI)
  • Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL*, 2002, “Modulation of dendritic cell differentiation and maturation by decoyreceptor 3”, JOURNAL OF IMMUNOLOGY, 168(10):4846-53. (SCI)
  • Chen BC, Hsieh SL, Lin WW, 2001, “Involvement of protein kinases in the potentiation of lipopolysaccharide-induced inflammatory mediator formation by thapsigargin in peritoneal macrophages”, JOURNAL OF LEUKOCYTE BIOLOGY, 69(2):280-8. (SCI)
  • Chen NJ, Huang MW, Hsieh SL*, 2001, “Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activation-induced cytokine”, JOURNAL OF IMMUNOLOGY, 166(1):270-6. (SCI)
  • Huang TH, Wu PY, Lee CN, Huang HI, Hsieh SL, Kung J, Tao MH, 2000, “Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen”, BLOOD, 96(12):3663-70. (SCI)
  • Chen MC, Hsu TL, Luh TY, Hsieh SL*, 2000, “Overexpression of bcl-2 enhances LIGHT- and interferon-gamma -mediatedapoptosis in Hep3BT2 cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 275(49):38794-801. (SCI)
  • K Tamada, K Shimozaki, AI Chapoval, Zhai Y, Su J, Chen SF, Hsieh SL, S Nagata, Ni J, Chen L., 2000, “LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response”, JOURNAL OF IMMUNOLOGY, 164(8):4105-10. (SCI)
  • Hsieh SL*, Chen N, K Tarbell, Liao N, Lai Y, Lee K, Lee K, Wu S, Sytwu H, Han SH, H McDevitt., 2000, “Transgenic mice expressing surface markers for IFN-gamma and IL-4producing cells”, MOLECULAR IMMUNOLOGY, 37(6):281-93. (SCI)
  • Wu MY, Wang PY, Han SH, Hsieh SL*, 1999, “The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 274(17):11868-73. (SCI)
  • N Gomez-Escobar, Chou CF, Lin WW, Hsieh SL, RD Campbell., 1998, “The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 273(47):30954-60. (SCI)
  • Zhai Y, R. Guo, Hsu TL, Yu GL, Ni J, Kwon BS, Jiang GW, Lu Tan JJ, M. Ugustus, K. Carter, L. Rojas, Zhu F, C. Lincoln, G. Endress, Xing L, Wang S, K. O. Oh, R. Gentz, S. Ruben, M. E. Lippman, Hsieh SL, Yang D, 1998, “LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM inducesapoptosis and suppresses in vivo tumor formation via gene transfer”, JOURNAL OF CLINICAL INVESTIGATION, 102(6):1142-51. (SCI)
  • Wu MY, Hsu TL, Lin WW, RD Campbell, Hsieh SL*., 1997, “Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 272(27):17154-9. (SCI)
  • Hsieh SL, RE March, A Khanna, SJ Cross, RD Campbell., 1997, “Mapping of 10 novel microsatellites in the MHC class III region:application to the study of autoimmune disease”, JOURNAL OF RHEUMATOLOGY, 24(1):220-2. (SCI)
  • CA Sargent, MJ Anderson, Hsieh SL, E Kendall, N Gomez-Escobar, RD Campbell., 1994, “Characterisation of the novel gene G11 lying adjacent to the complementC4A gene in the human major histocompatibility complex”, HUMAN MOLECULAR GENETICS, 3(3):481-8. (SCI)
  • Zhu ZB, Hsieh SL, DR Bentley, RD Campbell, JE Volanakis, 1992, “A variable number of tandem repeats locus within the human complement C2gene is associated with a retroposon derived from a human endogenou”, JOURNAL OF EXPERIMENTAL MEDICINE, 175(6):1783-7. (SCI)
  • Hsieh SL, RD Campbell., 1991, “Evidence that gene G7a in the human major histocompatibility complexencodes valyl-tRNA synthetase”, Biochem J, 278(3):809-16. (SCI)