Hung, Shang-Cheng

Distinguished Research Fellow / Division Director of Chemical Biology


Email:
Telephone: +886-2-27871279
 



EDUCATION AND POSITIONS HELD:

  • Ph.D., Chemistry, National Tsing Hua University, 1992
  • Postdoctoral Fellow, University of California at Berkeley, 1994-1995
  • Postdoctoral Fellow, The Scripps Research Institute, 1995-1998
  • Assistant Research Fellow, Institute of Chemistry, Academia Sinica, 1998-2002
  • Associate Research Fellow, Institute of Chemistry, Academia Sinica, 2002-2005
  • Associate Professor, Department of Chemistry, National Tsing Hua University, 2005-2006
  • Professor, Department of Chemistry, National Tsing Hua University, 2006-2007
  • Distinguished Professor, Department of Chemistry, National Tsing Hua University, 2007-2009
  • Research Fellow, Genomics Research Center, Academia Sinica, 2009-2012
  • Adjunct Professor, Department of Applied Chemistry, National Chiao Tung University, 2010-present
  • Distinguished Research Fellow, Genomics Research Center, Academia Sinica, 2012-present

HONORS:

  • Postdoctoral Fellowship, Educational Ministry, 1994
  • Young Scholar Research Publication Award, Academia Sinica, 2002
  • Outstanding Young Investigator Award, The Chinese Chemical Society, 2002
  • Outstanding Young Scholar Award, Tsing-Hua Fundation of Chemistry Technology, 2003
  • Travel Grant Award for Young Chemists, IUPAC, 2003
  • Mr. Tayou Wu Memorial Award, National Science Council, 2003
  • Distinguished Research Award, National Science Council, 2004
  • Outstanding Youth Medal, China Youth Corps, 2005
  • Letcureship Award, International Conference on Cutting-Edge Organic Chemistry in Asia, 2006
  • Yu-Ziang Hsu Scientific Paper Award, Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation, 2008
  • Distinguished Teaching Award, National Tsing Hua University, 2008
  • Investigator Award, Academia Sinica, 2009
  • Academic Publication Award, Chung-Shan Academic and Cultural Foundation, 2009
  • Best Annual Article Award, The Chinese Chemical Society, 2009
  • Distiguished Research Award, National Science Council, 2009-2011
  • 17th Teco Award, Teco Technology Foundation, 2010
  • NSC 2012 Outstanding Research Award, 2012

RESEARCH INTERESTS:

Carbohydrate Synthesis, Glycotechnology, and Glycobiology

Hung_lab
Regioselective One-pot Protection of Carbohydrates

 

The research in Dr. Hung’s group aims on the development of novel methodologies for the synthesis of biologically potent oligosaccharides, glycolipids, and glycoproteins via a combination of regioselective one-pot protection and stereoselective one-pot glycosylation. The major interests include three topics:

 
  • Discovery of new technologies for carbohydrate synthesis
  • Preparation of cell-surfaced carbohydrates (heparin/heparan sulfate, GPI anchors) and mycobacterial cell envelope components
  • Development of heparin-related microarrays, dendrimers, and nanoparticles
  • Study of heparin-protein interaction
  • Investigation of carbohydrate-based anti-tuberculosis vaccines

SELECTED PUBLICATIONS:

  • Huang, T.-Y.; Zulueta, M. M. L.; Hung, S.-C., 2014, “Regioselective One-pot Protection, Protection-Glycosylation and Protection- Glycosylation-Glycosylation of Carbohydrates: A Case Study with D-Glucose”, Organic & Biomolecular Chemistry, 12(2), 376-382. (SCI)
  • Patil, P. S.; Zulueta, M. M. L.; Hung, S.-C., 2014, “Synthesis of Mycobacterial Phosphatidylinositol Mannosides”, Journal of the Chinese Chemical Society, 61(S1), 151-162. (SCI)
  • Zulueta, M. M. L.; Lin, S.-Y.; Hung, S.-C., 2013, “Chemical Synthesis of Oligosaccharides Based on Heparin and Heparan Sulfate”, Trends in Glycoscience and Glycotechnology, 25, 141-158. (SCI)
  • Patil, P. S.; Lee, C.-C.; Huang, Y.-W.; Zulueta, M. M. L.; Hung, S.-C., 2013, “Regioselective and Stereoselective Benzylidene Installation and One-pot Protection of D-mannose”, Organic & Biomolecular Chemistry, 11(16), 2605-2612. (SCI)
  • Lu, F.-C.; Lico, L. S.; Hung, S.-C., 2013, “Synthesis of Fluorogenic Substrate for α-L-Iduronidase”, Akivoc, 2013(2), 13-21. (Science Citation Index Expande)
  • Zulueta, M. M. L.; Zhong, Y.-Q.; Hung, S.-C., 2013, “Synthesis of Rare L-Hexoses and Their Related Biomolecules”, Chemical Communications, 49(32), 3275-3287. (SCI)
  • Woolfson, D. N.; Hung, S.-C., 2013, “Synthetic Biomolecules”, Current Opinion in Chemical Biology, 17(6), 925-928. (SCI)
  • Zulueta, M. M. L.; Lin, S.-Y.; Hu, Y.-P.; Hung, S.-C., 2013, “Synthetic Heparin and Heparan Sulfate Oligosaccharides and their Protein Interactions”, Current Opinion in Chemical Biology, 17(6), 1023-1029. (SCI)
  • Hu, Y.-P.; Zhong, Y.-Q.; Chen, Z.-G.; Chen, C.-Y.; Shi, Z.; Zulueta, M. M. L.; Ku, C.-C.; Lee, P.-Y.; Wang, C.-C.; Hung, S.-C., 2012, “Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor-1 Interaction”, J. Am. Chem. Soc., 134(51), 20722-20727. (SCI)
  • Zulueta, M. M. L.; Lin, S.-Y.; Lin, Y.-T.; Huang, C.-J.; Wang, C.-C.; Ku, C.-C.; Shi, Z.; Chyan, C.-L.; Irene, D.; Lim, L.-H.; Tsai, T.-I; Hu, Y.-P.; Liu, J.-Y.; Chang, W.; Arco, S. D.; Wong, C.-H.; Hung, S.-C., 2012, “α-Glycosylation by D-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogs that Interact with Mycobacterial Heparin-Binding Hemagglutinin”, J. Am. Chem. Soc., 134(21), 8988-8995. (SCI)
  • Hsu, Y.; Lu, X.-A.; Zulueta, M. M. L.; Tsai, C.-M.; Lin, K.-I; Hung, S.-C.; Wong, C.-H., 2012, “Acyl and Silyl Group Effects in Reactivity-based One-pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4”, J. Am. Chem. Soc., 134, 4549-4552. (SCI)
  • Luo, S.-Y.; Tripathi, A.; Zulueta, M. M. L.; Hung, S.-C., 2012, “2-Allylphenyl Glycosides as Glycosyl Donors for Sugar Coupling”, Carbohydrate Research, 352, 197-201. (SCI)
  • Hsu, C.-Y.; Lee, I-C.; Lico, L. S.; Uang, B.-J.; Hung, S.-C., 2012, “Synthesis of a Furanosyl-pyranone Derivative Related to the Tri-O-heterocyclic Core of Herbicidins”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 59, 421-425. (SCI)
  • Hung, S.-C.; Lu, X.-A.; Lee, J.-C.; Fang, S.-L.; Fan, T.-C.; Chang, M. D.-T.; Zulueta, M. M. L.; Chiu, L.-T., 2012, “Synthesis of Heparin Oligosaccharides and Their Interaction with Eosinophil-Derived Neurotoxin”, Org. Biomol. Chem., 10, 760-772. (SCI)
  • Hsu, C.-H.; Hung, S.-C.; Wu, C.-Y.; Wong, C.-H., 2011, “Toward Automatic Oligosaccharide Synthesis”, Angewandte Chemie-International Edition, 50(50), 11872-11923. (SCI)
  • Chung, C.-C.; Zulueta, M. M. L.; Padiyar, L. T.; Hung, S.-C., 2011, “Desymmetrization of 2,4,5,6-Tetra-O-benzyl-D-myo-inositol for the Synthesis of Mycothiol”, Org. Lett., 13, 5496–5499. (SCI)
  • Lee, I.-C.; Zulueta, M. M. L.; Shie, C.-R.; Arco, S. D.; Hung, S.-C., 2011, “Deuterium-Isotope Study on the Regioselective Ring Opening of Benzylidene Acetals”, Org. Biomol. Chem., 9, 7655–7658. (SCI)
  • Huang, T.-Y.; Zulueta, M. M. L.; Hung, S.-C., 2011, “One-Pot Strategies for the Synthesis of the Tetrasaccharide Linkage Region of Proteoglycans”, Org. Lett., 13, 1506–1509. (SCI)
  • Wang, C.-C.; Zulueta, M. M. L.; Hung, S.-C., 2011, “Regioselective One-pot Protection and Protection-glycosylation of Carbohydrates”, Chimia, 65, 54–58. (SCI)
  • Hu, Y.-P.; Lin, S.-Y.; Huang, C.-Y.; Zulueta, M. M. L.; Liu, J.-Y.; Chang, W.; Hung, S.-C., 2011, “Synthesis of 3-O-Sulfonated Cell-Surface Heparan Sulfate Octasaccharides that Inhibit Herpes Simplex Virus Type 1 Host-Cell Interaction”, Nature Chemistry, 3, 557–563. (SCI)
  • Wang, C.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C., 2011, “Synthesis of Hemagglutinin-Binding Trisaccharides”, Adv. Exp. Med. Biol., 705, 691-726. (SCI)
  • Chang, K.-L.; Zulueta, M. M. L.; Lu, X.-A.; Zhong, Y.-Q.; Hung, S.-C., 2010, “Regioselective One-pot Protection of D-Glucosamine”, J. Org. Chem, 75, 7424-7427. (SCI)
  • Patil, P. S.; Hung, S.-C., 2010, “Synthesis of Mycobacterial Triacylated Phosphatidylinositol Dimannoside Containing an Acyl Lipid Chain at 3-O of Inositol”, Org. Lett., 12, 2618-2621. (SCI)
  • Padiyar, L. T.; Wen, Y.-S.; Hung, S.-C., 2010, “Metal Trifluromethanesulfonate-Catalyzed Regioselective Acylation of myo-Inositol Orthoformate”, Chem. Commun., 46, 5524-5526. (SCI)
  • Hung, S.-C., 2010, “Synthesis of Mycobacterial Cell Envelope Components”, Natural Sciences Newsletter, 22, 43-46.
  • Shie, C.-R.; Tzeng, Z.-H.; Wang, C.-C.; Hung, S.-C. , 2009, “Metal Trifluoromethanesulfonate-Catalyzed Regioselective Reductive Ring Opening of Benzylidene Acetals: A Plausible Mechanism Based on Isotope Studies”, Journal of the Chinese Chemical Society, 56, 510–523. (SCI)
  • Chi, F.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C. , 2009, “Synthesis of Alginate Oligosaccharides Containing L-Guluronic Acids”, Chemistry-An Asian Journal, 4, 386–390. (SCI)
  • Patil, P. S.; Hung, S.-C., 2009, “Total Synthesis of Phosphatidylinositol Dimmanoside: A Cell-Envelope Component of Mycobacterium tuberculosis”, Chemistry-A European Journal, 15, 1091–1094. (SCI)
  • Luo, S.-Y.; Jang, Y.-J.; Liu, J.-Y.; Chu, C.-S.; Liao, C.-C.; Hung, S.-C., 2008, “Carbohydrates-Templated Asymmetric Diels-Alder Reactions of Masked ortho-Benzoquinones for the Synthesis of Chiral Bicyclo[2.2.2]oct-5-en-2-ones”, Angewandte Chemie-International Edition, 47, 8082–8085. (SCI)
  • Fan, T.-C.; Fang, S.-L.; Hwang, C.-S.; Hsu, C.-Y.; Lu, X.-A.; Hung, S.-C.; Lin, S.-C.; Chang, M. D.-T. , 2008, “Characterization of Molecular Interactions between Eosinophil Cationic Protein and Heparin”, J. Biol. Chem., 283, 25468–25474. (SCI)
  • Wang, C.-C.; Kulkarni, S. S.; Lee, J.-C.; Luo, S.-Y.; Hung, S.-C. , 2008, “Regioselective One-pot Protection of Glucose”, Nat. Protoc, 3, 97–113. (SCI)
  • Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Kulkarni, S. S.; Huang, Y.-W.; Lee, C.-C.; Chang, K.-L.; Hung, S.-C., 2007, “Regioselective One-pot Protection of Carbohydrates”, Nature, 446, 896–899. (SCI)
  • Wang, C.-C.; Kulkarni, S. S.; Hung, S.-C., 2007, “Regioselective One-pot Protection of Carbohydrates”, Synform, 3, A32–A34.
  • Luo, S.-Y.; Kulkarni, S. S.; Chou, C.-H.; Liao, W.-M.; Hung, S.-C., 2006, “A Concise Synthesis of Tetrahydroxy-LCB, -Galactosyl Ceramide, and 1,4-Dideoxy-1,4-imino-L-ribitol via D-Allosamines as Key Building Blocks”, J. Org. Chem., 71, 1226–1229. (SCI)
  • Lu, L.-D.; Shie, C.-R.; Kulkarni, S. S.; Pan, G.-R.; Lu, X.-A.; Hung, S.-C., 2006, “Synthesis of 48 Disaccharide Building Blocks for the Assembly of a Heparin and Heparan Sulfate Oligosaccharide Library”, Org. Lett, 8, 5995–5998. (SCI)
  • Shie, C.-R.; Tzeng, Z.-H.; Kulkarni, S. S.; Uang, B.-J.; Hsu, C.-Y.; Hung, S.-C. , 2005, “Cu(OTf)2 as an Efficient and Dual-Purpose Catalyst in the Regioselective Reductive Ring Opening of Benzylidene Acetals”, Angewandte Chemie-International Edition, 44, 1665–1668. (SCI)
  • Kulkarni, S. S.; Liu, Y.-H.; Hung, S.-C., 2005, “Neighboring Group Participation of 9-Anthracenylmethyl Group in Glycosylation: Preparation of Unusual C-Glycosides”, J. Org. Chem., 70, 2808–2811. (SCI)
  • Lee, J.-C.; Chang, S.-W.; Liao, C.-C.; Chi, F.-C.; Chen, C.-S.; Wen, Y.-S.; Wang, C.-C.; Kulkarni, S. S.; Puranik, R.; Liu, Y.-H.; Hung, S.-C., 2004, “From D-Glucose to Biologically Potent L-Hexoses: Synthesis of -L-Iduronidase Fluorogenic Detector and the Disaccharide Moieties of Bleomycin A2 and Heparan Sulfate”, Chemistry-A European Journal, 10, 399–415. (SCI)
  • Chou, C. H., Wu, C. S., Chen, C. H., Lu, L. D., Kulkarni, S. S., Wong, C. H. and Hung, S. C., 2004, “Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues.”, Org Lett, 6(4), 585-588. (SCI)
  • Lee, C.-J.; Lu, X.-A.; Kulkarni, S. S.; Wen, Y.-S.; Hung, S.-C., 2004, “Synthesis of Heparin Oligosaccharides”, J. Am. Chem. Soc., 126, 476–477. (SCI)
  • Tai, C.-A.; Kulkarni, S. S.; Hung, S.-C. , 2003, “Facile Cu(OTf)2-catalyzed Preparation of Per-O-acetylated Hexopyranoses with Stoichiometric Acetic Anhydride and Sequential One-pot Anomeric Substitution to Thioglycosides under Solvent-free Conditions”, J. Org. Chem., 68, 8719–8722. (SCI)
  • Hung, S.-C.; Wen, Y.-F.; Chang, J.-W.; Liao, C.-C.; Uang, B.-J., 2002, “A Highly Diastereoselective Synthesis of (1R)-(+)-Camphor Based Chiral Allenes and their Asymmetric Hydroboration-Oxidation Reactions”, J. Org. Chem., 67, 1308–1313. (SCI)
  • Wang, C.-C.; Luo, S.-Y.; Shie, C.-R.; Hung, S.-C., 2002, “Metal Trifluoromethanesulfonate-Catalyzed Regioselective Borane-Reductive Ring Opening of Benzylidene Acetals: A Concise Synthesis of 1,4-Dideoxy-1,4-imino-L- xylitol”, Org. Lett., 4, 847–849. (SCI)
  • Lin, T.-S.; Chia, C.-M.; Hsiao, J.-C.; Chang, W.; Ku, C.-C.; Hung, S.-C.; Tzou, D.-L. M., 2002, “Structural analysis of the extracellular domain of vaccinia virus envelope protein, A27L, by NMR and CD spectroscopy”, J. Biol. Chem., 277, 20949–20959. (SCI)
  • Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Fan, H.-F.; Pai, C.-L.; Yang, W.-C.; Lu, L.-D.; Hung, S.-C., 2002, “Synthesis of Biologically Potent 12 Linked Disaccharide Derivatives via Regioselective One-pot Protection-glycosylation”, Angewandte Chemie-International Edition, 41, 2360–2362. (SCI)
  • Hung, S.-C.; Thopate, S. R.; Chi, F.-C.; Chang, S.-W.; Lee, J.-C.; Wang, C.-C.; Wen, Y.-S., 2001, “1,6-Anhydro--L-hexopyranoses as Potent Synthons in the Synthesis of the Disaccharide Units of Bleomycin A2 and Heparin”, J. Am. Chem. Soc., 123, 3153–3154. (SCI)