Hung, Shang-Cheng

HungSC6x7Distinguished Professor
Director


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Telephone: +886-2-27871279 / +886-2-27871200 
 
 

IBMI Award516  

EDUCATION AND POSITIONS HELD:

  • Ph.D., Chemistry, National Tsing Hua University, 1992
  • Postdoctoral Fellow, University of California at Berkeley, 1994-1995
  • Postdoctoral Fellow, The Scripps Research Institute, 1995-1998
  • Assistant Research Fellow, Institute of Chemistry, Academia Sinica, 1998-2002
  • Associate Research Fellow, Institute of Chemistry, Academia Sinica, 2002-2005
  • Associate Professor, Department of Chemistry, National Tsing Hua University, 2005-2006
  • Professor, Department of Chemistry, National Tsing Hua University, 2006-2007
  • Distinguished Professor, Department of Chemistry, National Tsing Hua University, 2007-2009
  • Professor, Genomics Research Center, Academia Sinica, 2009-2012
  • Adjunct Professor, Department of Applied Chemistry, National Chiao Tung University, 2010-present
  • Distinguished Professor, Genomics Research Center, Academia Sinica, 2012-present
  • Director, Genomics Research Center, Academia Sinica, 2016-present
  • Acting Division Director of Biotechnology Incubation Center, Genomics Research Center, Academia Sinica, 2016-2018

HONORS:

  • Postdoctoral Fellowship, Educational Ministry, 1994
  • Young Scholar Research Publication Award, Academia Sinica, 2002
  • Outstanding Young Investigator Award, The Chinese Chemical Society, 2002
  • Outstanding Young Scholar Award, Tsing-Hua Fundation of Chemistry Technology, 2003
  • Travel Grant Award for Young Chemists, IUPAC, 2003
  • Mr. Tayou Wu Memorial Award, National Science Council, 2003
  • Distinguished Research Award, National Science Council, 2004
  • Outstanding Youth Medal, China Youth Corps, 2005
  • Letcureship Award, International Conference on Cutting-Edge Organic Chemistry in Asia, 2006
  • Yu-Ziang Hsu Scientific Paper Award, Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation, 2008
  • Distinguished Teaching Award, National Tsing Hua University, 2008
  • Academic Publication Award, Chung-Shan Academic and Cultural Foundation, 2009
  • Best Annual Article Award, The Chinese Chemical Society, 2009
  • Distinguished Research Award, National Science Council, 2009-2011
  • 17th Teco Award, Teco Technology Foundation, 2010
  • NSC 2012 Outstanding Research Award, 2012

RESEARCH INTERESTS:

Carbohydrate Synthesis, Glycotechnology, and Glycobiology

The research in Dr. Hung’s group aims on the development of novel methodologies for the synthesis of biologically potent oligosaccharides, glycolipids, and glycoproteins via a combination of regioselective one-pot protection and stereoselective one-pot glycosylation. The major interests include five topics:

  • Discovery of new technologies for carbohydrate synthesis
  • Preparation of cell-surfaced carbohydrates (heparin/heparan sulfate, GPI anchors) and mycobacterial cell envelope components
  • Development of heparin-related microarrays, dendrimers, and nanoparticles
  • Study of heparin-protein interaction
  • Investigation of carbohydrate-based anti-tuberculosis vaccines
 Hung lab
Regioselective One-pot Protection of Carbohydrates

SELECTED PUBLICATIONS:

  • Sakamoto K, Ozaki T, Ko YC, Tsai CF, Gong Y, Morozumi M, Ishikawa Y, Uchimura K, Nadanaka S, Kitagawa H, Zulueta MML, Bandaru A, Tamura JI, Hung SC, Kadomatsu K, 2019, “Glycan sulfation patterns define autophagy flux at axon tip via PTPRsigma-cortactin axis.”, Nature Chemical Biology, 15(7), 699-709. (SCIE) (IF: 13.843; SCIE ranking: 2%)
  • Kuwabara K; Nishitsuji K; Uchimura K; Hung SC; Mizuguchi M; Nakajima H; Mikawa S; Kobayashi N; Saito H; Sakashita N., 2015, “Cellular interaction and cytotoxicity of the Iowa mutation of apolipoprotein A-I (ApoA-IIowa) amyloid mediated by sulfate moieties of heparan sulfate.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 24210-24221. (SCIE) (IF: 4.125; SCIE ranking: 25.5%)
  • Medel Manuel L. Zulueta, Donala Janreddy andShang-Cheng Hung, 2015, “One-Pot Methods for the Protection and Assembly of Sugars”, ISRAEL JOURNAL OF CHEMISTRY, 55(3), 347-359. (SCIE) (IF: 2.607; SCIE ranking: 44.4%)
  • Patil PS; Cheng TJR; Zulueta MM; Yang ST; Lico LS; Hung SC., 2015, “Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity.”, Nat Commun., 6, 7239. (SCIE) (IF: 12.124; SCIE ranking: 4.7%)
  • Ko YC; Tsai CF; Wang CC; Dhurandhare VM; Hu PL; Su TY; Lico LS; Zulueta MM; Hung SC., 2014, “Microwave-assisted one-pot synthesis of 1,6-anhydrosugars and orthogonally protected thioglycosides.”, J Am Chem Soc., 136, 14425-14431. (SCIE) (IF: 13.858; SCIE ranking: 6%)
  • Chang CH; Lico LS; Huang TY; Lin SY; Chang CL; Arco SD; Hung SC., 2014, “Synthesis of the heparin-based anticoagulant drug Fondaparinux.”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 9876-9879. (SCIE) (IF: 11.994; SCIE ranking: 7.8%)
  • Li YC; Ho IH; Ku CC; Zhong YQ; Hu YP; Chen ZG; Chen CY; Lin WC; Zulueta MM; Hung SC; Lin MG; Wang CC; Hsiao CD., 2014, “Interactions That Influence the Binding of Synthetic Heparan Sulfate Based Disaccharides to Fibroblast Growth Factor-2”, ACS Chem Biol., 9, 1912-1717. (SCIE) (IF: 4.995; SCIE ranking: 17.2%)
  • Hsu Y; Ma HH; Lico LS; Jan JT; Fukase K; Uchinashi Y; Zulueta MM; Hung SC., 2014, “One-pot synthesis of N-acetyl- and N-glycolylneuraminic acid capped trisaccharides and evaluation of their influenza A(H1N1) inhibition.”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 2413-2416. (SCIE) (IF: 11.994; SCIE ranking: 7.8%)
  • Patil, P. S.; Zulueta, M. M. L.; Hung, S.-C., 2014, “Synthesis of Phosphatidylinositol Mannosides”, Journal of the Chinese Chemical Society, 61, 151-162. (SCIE) (IF: 0.862; SCIE ranking: 78.9%)
  • Huang, T.-Y.; Zulueta, M. M. L.; Hung, S.-C., 2014, “Regioselective One-pot Protection, Protection-Glycosylation and Protection- Glycosylation-Glycosylation of Carbohydrates: A Case Study with D-Glucose”, Organic & Biomolecular Chemistry, 12(2), 376-382. (SCIE) (IF: 3.423; SCIE ranking: 28.1%)
  • Zulueta, M. M. L.; Lin, S.-Y.; Hung, S.-C., 2013, “Chemical Synthesis of Oligosaccharides Based on Heparin and Heparan Sulfate”, Trends in Glycoscience and Glycotechnology, 25, 141-158. (SCIE) (IF: 0.3; SCIE ranking: 99.3%)
  • Patil, P. S.; Lee, C.-C.; Huang, Y.-W.; Zulueta, M. M. L.; Hung, S.-C., 2013, “Regioselective and Stereoselective Benzylidene Installation and One-pot Protection of D-mannose”, Organic & Biomolecular Chemistry, 11(16), 2605-2612. (SCIE) (IF: 3.423; SCIE ranking: 28.1%)
  • Lu, F.-C.; Lico, L. S.; Hung, S.-C., 2013, “Synthesis of Fluorogenic Substrate for α-L-Iduronidase”, ARKIVOC, 2013(2), 13-21. (SCIE, Science Citation Index Expande) (IF: 1.048; SCIE ranking: 73.7%)
  • Zulueta, M. M. L.; Zhong, Y.-Q.; Hung, S.-C., 2013, “Synthesis of Rare L-Hexoses and Their Related Biomolecules”, Chemical Communications, 49(32), 3275-3287. (SCIE) (IF: 6.29; SCIE ranking: 16.4%)
  • Woolfson, D. N.; Hung, S.-C., 2013, “Synthetic Biomolecules”, Current Opinion in Chemical Biology, 17(6), 925-928. (SCIE) (IF: 7.572; SCIE ranking: 9.6%,8.3%)
  • Zulueta, M. M. L.; Lin, S.-Y.; Hu, Y.-P.; Hung, S.-C., 2013, “Synthetic Heparin and Heparan Sulfate Oligosaccharides and their Protein Interactions”, Current Opinion in Chemical Biology, 17(6), 1023-1029. (SCIE) (IF: 7.572; SCIE ranking: 9.6%,8.3%)
  • Hu, Y.-P.; Zhong, Y.-Q.; Chen, Z.-G.; Chen, C.-Y.; Shi, Z.; Zulueta, M. M. L.; Ku, C.-C.; Lee, P.-Y.; Wang, C.-C.; Hung, S.-C., 2012, “Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor-1 Interaction”, J. Am. Chem. Soc., 134(51), 20722-20727. (SCIE) (IF: 14.357; SCIE ranking: 4.7%)
  • Zulueta, M. M. L.; Lin, S.-Y.; Lin, Y.-T.; Huang, C.-J.; Wang, C.-C.; Ku, C.-C.; Shi, Z.; Chyan, C.-L.; Irene, D.; Lim, L.-H.; Tsai, T.-I; Hu, Y.-P.; Liu, J.-Y.; Chang, W.; Arco, S. D.; Wong, C.-H.; Hung, S.-C., 2012, “α-Glycosylation by D-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogs that Interact with Mycobacterial Heparin-Binding Hemagglutinin”, J. Am. Chem. Soc., 134(21), 8988-8995. (SCIE) (IF: 14.357; SCIE ranking: 4.7%)
  • Hsu, Y.; Lu, X.-A.; Zulueta, M. M. L.; Tsai, C.-M.; Lin, K.-I; Hung, S.-C.; Wong, C.-H., 2012, “Acyl and Silyl Group Effects in Reactivity-based One-pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4”, J. Am. Chem. Soc., 134, 4549-4552. (SCIE) (IF: 14.357; SCIE ranking: 4.7%)
  • Luo, S.-Y.; Tripathi, A.; Zulueta, M. M. L.; Hung, S.-C., 2012, “2-Allylphenyl Glycosides as Glycosyl Donors for Sugar Coupling”, Carbohydrate Research, 352, 197-201. (SCIE) (IF: 2.074; SCIE ranking: 49.1%,43.1%,70.6%)
  • Hsu, C.-Y.; Lee, I-C.; Lico, L. S.; Uang, B.-J.; Hung, S.-C., 2012, “Synthesis of a Furanosyl-pyranone Derivative Related to the Tri-O-heterocyclic Core of Herbicidins”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 59, 421-425. (SCIE) (IF: 0.862; SCIE ranking: 78.9%)
  • Hung, S.-C.; Lu, X.-A.; Lee, J.-C.; Fang, S.-L.; Fan, T.-C.; Chang, M. D.-T.; Zulueta, M. M. L.; Chiu, L.-T., 2012, “Synthesis of Heparin Oligosaccharides and Their Interaction with Eosinophil-Derived Neurotoxin”, Org. Biomol. Chem., 10, 760-772. (SCIE) (IF: 3.423; SCIE ranking: 28.1%)
  • Hsu, C.-H.; Hung, S.-C.; Wu, C.-Y.; Wong, C.-H., 2011, “Toward Automatic Oligosaccharide Synthesis”, Angewandte Chemie-International Edition, 50(50), 11872-11923. (SCIE) (IF: 12.102; SCIE ranking: 8.2%)
  • Chung, C.-C.; Zulueta, M. M. L.; Padiyar, L. T.; Hung, S.-C., 2011, “Desymmetrization of 2,4,5,6-Tetra-O-benzyl-D-myo-inositol for the Synthesis of Mycothiol”, Org. Lett., 13, 5496–5499. (SCIE) (IF: 6.492; SCIE ranking: 5.3%)
  • Lee, I.-C.; Zulueta, M. M. L.; Shie, C.-R.; Arco, S. D.; Hung, S.-C., 2011, “Deuterium-Isotope Study on the Regioselective Ring Opening of Benzylidene Acetals”, Org. Biomol. Chem., 9, 7655–7658. (SCIE) (IF: 3.423; SCIE ranking: 28.1%)
  • Huang, T.-Y.; Zulueta, M. M. L.; Hung, S.-C., 2011, “One-Pot Strategies for the Synthesis of the Tetrasaccharide Linkage Region of Proteoglycans”, Org. Lett., 13, 1506–1509. (SCIE) (IF: 6.492; SCIE ranking: 5.3%)
  • Wang, C.-C.; Zulueta, M. M. L.; Hung, S.-C., 2011, “Regioselective One-pot Protection and Protection-glycosylation of Carbohydrates”, Chimia, 65, 54-58. (SCIE) (IF: 1.245; SCIE ranking: 70.8%)
  • Hu, Y.-P.; Lin, S.-Y.; Huang, C.-Y.; Zulueta, M. M. L.; Liu, J.-Y.; Chang, W.; Hung, S.-C., 2011, “Synthesis of 3-O-Sulfonated Cell-Surface Heparan Sulfate Octasaccharides that Inhibit Herpes Simplex Virus Type 1 Host-Cell Interaction”, Nature Chemistry, 3, 557–563. (SCIE) (IF: 26.201; SCIE ranking: 2.3%)
  • Wang, C.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C., 2011, “Synthesis of Hemagglutinin-Binding Trisaccharides”, Advances in Experimental Medicine and Biology, 705, 691-726. (SCIE) (IF: 1.76; SCIE ranking: 72.2%,44.7%)
  • Chang, K.-L.; Zulueta, M. M. L.; Lu, X.-A.; Zhong, Y.-Q.; Hung, S.-C., 2010, “Regioselective One-pot Protection of D-Glucosamine”, J. Org. Chem, 75, 7424-7427. (SCIE) (IF: 4.805; SCIE ranking: 15.8%)
  • Patil, P. S.; Hung, S.-C., 2010, “Synthesis of Mycobacterial Triacylated Phosphatidylinositol Dimannoside Containing an Acyl Lipid Chain at 3-O of Inositol”, Org. Lett., 12, 2618-2621. (SCIE) (IF: 6.492; SCIE ranking: 5.3%)
  • Padiyar, L. T.; Wen, Y.-S.; Hung, S.-C., 2010, “Metal Trifluromethanesulfonate-Catalyzed Regioselective Acylation of myo-Inositol Orthoformate”, Chem. Commun., 46, 5524-5526. (SCIE) (IF: 6.29; SCIE ranking: 16.4%)
  • Hung, S.-C., 2010, “Synthesis of Mycobacterial Cell Envelope Components”, Natural Sciences Newsletter, 22, 43-46.
  • Shie, C.-R.; Tzeng, Z.-H.; Wang, C.-C.; Hung, S.-C. , 2009, “Metal Trifluoromethanesulfonate-Catalyzed Regioselective Reductive Ring Opening of Benzylidene Acetals”, Journal of the Chinese Chemical Society, 56, 510–523. (SCIE) (IF: 0.862; SCIE ranking: 78.9%)
  • Chi, F.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C. , 2009, “Synthesis of Alginate Oligosaccharides Containing L-Guluronic Acids”, Chemistry-An Asian Journal, 4, 386–390. (SCIE) (IF: 3.692; SCIE ranking: 29.8%)
  • Patil, P. S.; Hung, S.-C., 2009, “Total Synthesis of Phosphatidylinositol Dimmanoside: A Cell-Envelope Component of Mycobacterium tuberculosis”, Chemistry-A European Journal, 15, 1091–1094. (SCIE) (IF: 5.16; SCIE ranking: 21.6%)
  • Luo, S.-Y.; Jang, Y.-J.; Liu, J.-Y.; Chu, C.-S.; Liao, C.-C.; Hung, S.-C., 2008, “Carbohydrates-Templated Asymmetric Diels-Alder Reactions of Masked ortho-Benzoquinones for the Synthesis of Chiral Bicyclo[2.2.2]oct-5-en-2-ones”, Angewandte Chemie-International Edition, 47, 8082–8085. (SCIE) (IF: 12.102; SCIE ranking: 8.2%)
  • Fan, T.-C.; Fang, S.-L.; Hwang, C.-S.; Hsu, C.-Y.; Lu, X.-A.; Hung, S.-C.; Lin, S.-C.; Chang, M. D.-T. , 2008, “Characterization of Molecular Interactions between Eosinophil Cationic Protein and Heparin”, J. Biol. Chem., 283, 25468–25474. (SCIE) (IF: 4.011; SCIE ranking: 25.6%)
  • Wang, C.-C.; Kulkarni, S. S.; Lee, J.-C.; Luo, S.-Y.; Hung, S.-C. , 2008, “Regioselective One-pot Protection of Glucose”, Nat. Protoc, 3, 97–113. (SCIE) (IF: 12.423; SCIE ranking: 2.5%)
  • Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Kulkarni, S. S.; Huang, Y.-W.; Lee, C.-C.; Chang, K.-L.; Hung, S.-C., 2007, “Regioselective One-pot Protection of Carbohydrates”, Nature, 446, 896–899. (SCIE) (IF: 41.577; SCIE ranking: 1.6%)
  • Wang, C.-C.; Kulkarni, S. S.; Hung, S.-C., 2007, “Regioselective One-pot Protection of Carbohydrates”, Synform, 3, A32–A34.
  • Luo, S.-Y.; Kulkarni, S. S.; Chou, C.-H.; Liao, W.-M.; Hung, S.-C., 2006, “A Concise Synthesis of Tetrahydroxy-LCB, -Galactosyl Ceramide, and 1,4-Dideoxy-1,4-imino-L-ribitol via D-Allosamines as Key Building Blocks”, J. Org. Chem., 71, 1226–1229. (SCIE) (IF: 4.805; SCIE ranking: 15.8%)
  • Lu, L.-D.; Shie, C.-R.; Kulkarni, S. S.; Pan, G.-R.; Lu, X.-A.; Hung, S.-C., 2006, “Synthesis of 48 Disaccharide Building Blocks for the Assembly of a Heparin and Heparan Sulfate Oligosaccharide Library”, Org. Lett, 8, 5995–5998. (SCIE) (IF: 6.492; SCIE ranking: 5.3%)
  • Shie, C.-R.; Tzeng, Z.-H.; Kulkarni, S. S.; Uang, B.-J.; Hsu, C.-Y.; Hung, S.-C. , 2005, “Cu(OTf)2 as an Efficient and Dual-Purpose Catalyst in the Regioselective Reductive Ring Opening of Benzylidene Acetals”, Angewandte Chemie-International Edition, 44, 1665–1668. (SCIE) (IF: 12.102; SCIE ranking: 8.2%)
  • Kulkarni, S. S.; Liu, Y.-H.; Hung, S.-C., 2005, “Neighboring Group Participation of 9-Anthracenylmethyl Group in Glycosylation: Preparation of Unusual C-Glycosides”, J. Org. Chem., 70, 2808–2811. (SCIE) (IF: 4.805; SCIE ranking: 15.8%)
  • Lee, J.-C.; Chang, S.-W.; Liao, C.-C.; Chi, F.-C.; Chen, C.-S.; Wen, Y.-S.; Wang, C.-C.; Kulkarni, S. S.; Puranik, R.; Liu, Y.-H.; Hung, S.-C., 2004, “From D-Glucose to Biologically Potent L-Hexoses: Synthesis of -L-Iduronidase Fluorogenic Detector and the Disaccharide Moieties of Bleomycin A2 and Heparan Sulfate”, Chemistry-A European Journal, 10, 399–415. (SCIE) (IF: 5.16; SCIE ranking: 21.6%)
  • Chou, C. H., Wu, C. S., Chen, C. H., Lu, L. D., Kulkarni, S. S., Wong, C. H. and Hung, S. C., 2004, “Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues.”, Org Lett, 6(4), 585-588. (SCIE) (IF: 6.492; SCIE ranking: 5.3%)
  • Lee, C.-J.; Lu, X.-A.; Kulkarni, S. S.; Wen, Y.-S.; Hung, S.-C., 2004, “Synthesis of Heparin Oligosaccharides”, J. Am. Chem. Soc., 126, 476–477. (SCIE) (IF: 14.357; SCIE ranking: 4.7%)
  • Tai, C.-A.; Kulkarni, S. S.; Hung, S.-C. , 2003, “Facile Cu(OTf)2-catalyzed Preparation of Per-O-acetylated Hexopyranoses with Stoichiometric Acetic Anhydride and Sequential One-pot Anomeric Substitution to Thioglycosides under Solvent-free Conditions”, J. Org. Chem., 68, 8719–8722. (SCIE) (IF: 4.805; SCIE ranking: 15.8%)
  • Hung, S.-C.; Wen, Y.-F.; Chang, J.-W.; Liao, C.-C.; Uang, B.-J., 2002, “A Highly Diastereoselective Synthesis of (1R)-(+)-Camphor Based Chiral Allenes and their Asymmetric Hydroboration-Oxidation Reactions”, J. Org. Chem., 67, 1308–1313. (SCIE) (IF: 4.805; SCIE ranking: 15.8%)
  • Wang, C.-C.; Luo, S.-Y.; Shie, C.-R.; Hung, S.-C., 2002, “Metal Trifluoromethanesulfonate-Catalyzed Regioselective Borane-Reductive Ring Opening of Benzylidene Acetals: A Concise Synthesis of 1,4-Dideoxy-1,4-imino-L- xylitol”, Org. Lett., 4, 847–849. (SCIE) (IF: 6.492; SCIE ranking: 5.3%)
  • Lin, T.-S.; Chia, C.-M.; Hsiao, J.-C.; Chang, W.; Ku, C.-C.; Hung, S.-C.; Tzou, D.-L. M., 2002, “Structural analysis of the extracellular domain of vaccinia virus envelope protein, A27L, by NMR and CD spectroscopy”, J. Biol. Chem., 277, 20949–20959. (SCIE) (IF: 4.011; SCIE ranking: 25.6%)
  • Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Fan, H.-F.; Pai, C.-L.; Yang, W.-C.; Lu, L.-D.; Hung, S.-C., 2002, “Synthesis of Biologically Potent 12 Linked Disaccharide Derivatives via Regioselective One-pot Protection-glycosylation”, Angewandte Chemie-International Edition, 41, 2360–2362. (SCIE) (IF: 12.102; SCIE ranking: 8.2%)
  • Hung, S.-C.; Thopate, S. R.; Chi, F.-C.; Chang, S.-W.; Lee, J.-C.; Wang, C.-C.; Wen, Y.-S., 2001, “1,6-Anhydro--L-hexopyranoses as Potent Synthons in the Synthesis of the Disaccharide Units of Bleomycin A2 and Heparin”, J. Am. Chem. Soc., 123, 3153–3154. (SCIE) (IF: 14.357; SCIE ranking: 4.7%)