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Wong, Chi-Huey

President of Academia SinicaWongCH
Distinguished Research Fellow
Division Director of Chemical Biology


Email: chwong@gate.sinica.edu.tw
Telephone: +886-2-27871260
[ CV ]
[ Website ]



EDUCATION AND POSITIONS HELD:

  • Ph.D., Chemistry, Massachusetts Institute of Technology, 1982
  • Postdoctoral Fellow, Harvard University, 1982–1983
  • Assistant Professor through Professor of Chemistry and Biochemistry, Texas A&M University, 1983–1989
  • Head, Frontier Research Program on Glycotechnology, Institute of Physical and Chemical Research (RIKEN), Japan, 1991–1999.
  • Professor and Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 1989–2006.
  • Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 1996–2006.
  • Director, The Genomic Research Center, Acadmia Sinica, Taipei, Taiwan, 2003–2006.
  • President, Academia Sinica, Taipei, Taiwan, 2006-present.
  • Joint Appointment: Professor of Chemistry, The Scripps Research Institute; Distinguished Professor of Chemistry and Biochemical Sciences, National Taiwan University.

HONORS:

  • Searle Scholar Award in Biomedical Sciences, 1985
  • Presidential Young Investigator in Chemistry, 1986
  • The IUPAC International Carbohydrate Award, 1994
  • Elected Member of Academia Sinica, Taipei, 1994
  • Elected Member of the American Academy of Arts and Sciences, 1996
  • American Chemical Society Harrison Howe Award in Chemistry, 1998
  • American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry, 1999
  • The International Enzyme Engineering Award, 1999
  • Presidential Green Chemistry Award, USA, 2000
  • Elected Member of the National Academy of Sciences, USA 2002
  • American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 2005
  • The F. A. Cotton Medal for Excellence in Chemical Research, 2008
  • Editor-in-Chief, Bioorganic & Medicinal Chemistry, 1993–2010
  • Elected Associate Member of the European Molecular Biology Organization (EMBO), 2010
  • The American Chemical Society Arthur C. Cope Award, 2012
  • Nikkei Asia Prize for Science, Technology and Innovation, 2012

RESEARCH INTERESTS:

Chemical Biology and Drug Discovery

cell-surface-1-CH-WongResearch in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting proteins and RNA has been performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules. Development of both synthetic and bioorganic strategies is also paramount to our research. Programmable one-pot reactions are being developed for the synthesis of complex oligosaccharides and glycoarrays and compliment new strategies for the assembly of vaccines glycoproteins and other biologically active molecules to tackle major problems in biology, especially associated with cancer, infectious diseases and Immune system.

SELECTED PUBLICATIONS:

  • C.-S. Tsai, H.-Y. Yen, M.-I. Lin, T.-I. Tsai, S.-Y. Wang, W.-I. Huang, T.-L. Hsu, Y.-S. E. Cheng, J.-M. Fang, C.-H. Wong, 2013, “A Cell Permeable Probe for Identification and Imaging of Sialidases”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2466-2471. (SCI)
  • Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2517-2522. (SCI)
  • T.-J. R. Cheng, S.-Y. Wang, W.-H. Wen, C.-Y. Su, M. Lin, W.-I. Huang, M.-T. Liu, H.-S. Wu, N-S. Wang, C.-K. Cheng, C.-L. Chen, C.-T. Ren, C.-Y. Wu, J.-M. Fang, Y.-S. E. Cheng and C.-H. Wong, 2013, “Chemical probes for drug resistance assessment by binding competition (RABC) oseltamivir susceptibility evaluation”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(1), 366–370. (SCI)
  • C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2013, “Fucosyltransferase 8 as a Functional Regulator of Non-Small Cell Lung Cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(2), 630-635. (SCI)
  • C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong and C. Ma, 2012, “Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(17), 6496-6501. (SCI)
  • H.-W. Shih, Y.-F. Chang, W.-J. Li, F.-C. Meng, C.-Y. Huang, C. Ma, T.-J. R. Cheng, C.-H. Wong, W.-C. Cheng, 2012, “Effect of the peptide moiety of lipid II on bacterial transglycosylase”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(40), 10123-10126. (SCI)
  • K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, T.-A. Chao, Y.-F. Lin, S.-H. Wu, C.-H. Wong and C.-Y. Wu, 2011, “Efficient and Stereoselective Synthesis of α(2→9) Oligosialic Acids Up to Dodecamer”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(40), 9391-9395. (SCI)
  • Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, 2011, “Sialylation and Fucosylation of Epidermal Growth Factor Receptor Suppress its Dimerization and Activation in Lung Cancer Cells”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(28), 11332-11337. (SCI)
  • T.-N. Wu, K.-H. Lin, Y.-J. Chang, J.-R. Huang, J.-Y. Cheng, A. L. Yu, and C.-H. Wong, 2011, “Avidity of CD1d-ligand-receptor ternary complex contributes to Th1 polarization and anticancer efficacy”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(42), 17275-17280. (SCI)
  • Y.-F. Shen, Y.-H. Chen, S.-Y. Chu, M.-I. Lin, H.-T. Hsu, P.-Y. Wu, C.-J. Wu, H.-W. Liu, F.-Y. Lin, G. Lin, P.-H. Hsu, A.-S. Yang, Y.-S. E. Cheng, Y.-T. Wu, C.-H. Wong, and M.-D. Tsai, 2011, “E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(40), 16515-16520. (SCI)
  • C.-H. Liang, S.-K. Wang, C.-W. Lin, C.-C. Wang, C.-H. Wong, C.-Y. Wu, 2011, “Effects of neighboring glycans on antibody-carbohydrate interaction”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(7), 1608-1612. (SCI)
  • E. K. Culyba, J. L. Price, S. R. Hanson, A. Dhar, C.‐H. Wong, M. Gruebele, E. T. Powers and J. W. Kelly, 2011, “Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns”, Science, 331(6017), 571-575. (SCI)
  • C.-H. Hsu, S.-C. Hung, C.-Y. Wu, and C.-H. Wong, 2011, “Toward Automated Oligosaccharide Synthesis”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(50), 11872-11923. (SCI)
  • S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides Through Phosphonate Chemistry ”, J. Am. Chem. Soc, 132(38),13371-13380. (SCI)
  • S. R. Hanson, E. K. Culyba, T. L. Hsu, C.-H. Wong, J. W. Kelly, E. T. Powers, 2009, “The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability.”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(9), 3131-3136. (SCI)
  • C. Bennett, S. Dean, R. Payne, S. Ficht, A. Brik and C.-H. Wong, 2008, “Sugar-assisted Glycopeptide Ligation with Complex Oligosaccharides: Scope and Limitations”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(36), 11945-11952. (SCI)
  • T. L. Hsu, S. R. Hanson, K. Kishikawa, S. K. Wang, M. Sawa and C. H. Wong, 2007, “Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 2614-2619. (SCI)
  • M. Sawa, T.-L. Hsu, T. Itoh, M. Sugiyama, S. R. Hanson, P. K. Vogt, and C.-H. Wong, 2006, “Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(33), 12371-12376. (SCI)
  • O. Blixt, S. Head, T. Mondala, C. Scanlan, M.E. Huflejt, R. Alvarez, M.C. Bryan, F. Fazio, D. Calarese, J. Stevens, N. Razi, I. van Die, D. Burton, I.A. Wilson, R. Cummings, N. Bovin, C.-H. Wong, J.C. Paulson, 2004, “Printed covalent glycan array for ligand profiling of diverse glycan binding proteins”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 17033-17038. (SCI)
  • K. M. Koeller, C. H. Wong, 2001, “Enzymes for chemical synthesis”, NATURE, 409, 232-240. (SCI)
  • A. Heine, G. DeSantis, J. G. Luz, M. Mitchell, C. H. Wong and I. A. Wilson, 2001, “Observation of covalent intermediates in an enzyme mechanism at atomic resolution”, SCIENCE, 294, 369-374. (SCI)
  • P. Sears, C. H. Wong, 2001, “Toward automated synthesis of oligosaccharides and glycoproteins”, SCIENCE, 291, 2344-2350. (SCI)