Research Fellow

EDUCATION AND POSITIONS HELD:

• Ph.D., Chemistry, Iowa State University (1985)
• Visiting fellow, Cooperative Institute for Research in Environmental Sciences, Colorado (1985-1986)
• Postdoctoral fellow, Chemistry, University of Illinois (1986-1988)
• Associate research fellow through Research fellow, Institute of Atomic and Molecular Sciences, Academia Sinica (1988-present)

HONORS:

• Chair of the 7th international meeting on hole burning, single molecule and related spectroscopies: science and applications, November 18-23, 2001, Taipei, ROC.

RESEARCH INTERESTS:

We are interested in the study of the guest-host interaction in the condensed phases, particularly the molecular recognition and the structural dynamics in biological systems. Recently, we also put our attention on the design new molecules for fluorescence biomarkers and antitumor agents. Currently activities involve (1) Investigation of dye-DNA interaction by using spectroscopic methods to probe the binding sites between chromophore and DNA and to identify various DNA conformational structures, particularly the telomeric DNA; (2) Investigation of the structure-activity correlation of anti-telomerase agents; (3) Design and synthesis new compounds for antitumor agents and fluorescence biomarkers; (4) Monitoring the folding and unfolding of quadruplex structure, tracing the pathway of drug delivery and probing drug-target interaction by using single molecule microscopy and spectroscopy.

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