研究技師

EDUCATION AND POSITIONS HELD:

• Ph.D., Chemical Engineering Department of State University of New York at Buffalo, 1990–1996
• Postdoctoral Fellow, Academia Sinica, Taipei, 1996–2001
• Manager of Administrative Office of National Research Program for Genomic Medicine, 2001–2004
• Assistant Research Specialist of Genomic Research Center, Academia Sinica, Taipei, 2004–2007
• Associate Research Specialist of Genomic Research Center, Academia Sinica, Taipei, 2007-2012
• Research Specialist of Genomic Research Center, Academia Sinica, Taipei, 2012-present

FACILITY MANAGEMENT / EXPERTISE:

Structural Function to Drug Discovery

Our research will devote to facilitate technology for probing hot-area that link to specific function in biomolecular recognition and biomolecule-compound interactions, and to devise strategies for structure-based drug discovery as an integral part of the AS-GRC chemical biology research. The major duty, therefore, is to maintain an up-to-date in silico drug discovery platform and to implement new selection methods to assist research PIs in defining features of research targets for drug discovery. Computational approach will be using local surface searching, docking, and fragment-based filling methods, for starting template generation as well as for lead optimization.

研究興趣在致力於開發探測包括:蛋白質、DNA和RNA等生物分子間相互識別，以及生物分子與藥物間相互作用的技術，用以增進發現生物分子連絡特定功能的結構上熱區，結合使用結構為基礎的藥物設計策略，作為中心進行生物化學研究的整合技術。因此主要任務為維繫藥物研發技術平臺，以提供研究人員確定其標的物作為藥物設計目標的特徵。計算方法結合區域性的表面搜查，空間對接，片段底模充填法等技巧，以產生起始模板的結構資訊，以及進行先導藥物最佳化設計。

SELECTED PUBLICATIONS:

• Wu C.-H., Yen C.-J., Chou R.-H., Li S.-T., Huang W.-C., Ren C.-T., Wu C.-Y.*, Yu Y.-L.*, 2012, “Cancer-Associated Carbohydrate Antigens as Potential Biomarkers for Hepatocellular Carcinoma.”, PLoS One, 7, e39466. (SCI)
• Chung-Yi Wu; Hui-Chang Lin; Hsien-Jen Wu, 2012, “Sythesis of New Acetal Aza-Cage Compounds via Ozonolysis of Bis-endo-diol- and Diacylnornornese Derivatives”, TETRAHEDRON, 68, 2100-2106. (SCI)
• D Punyadarsaniya, C-H Liang, C Winter, H Petersen, S Rautenschlein, I Hennig-Pauka, C Schwegmann-Wessels, C-Y Wu, C-H Wong, G Herrler* , 2011, “Infection of differentiated porcine airway epithelial cells by influenza virus: differential susceptibility to infection by porcine and avian viruses”, PLoS One, 6(12), e28429. (SCI)
• Che-Hsiung Hsu, Shang-Cheng Hung*, Chung-Yi Wu*, and Chi-Huey Wong*, 2011, “Toward Automated Oligosaccharide Synthesis”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(50), 11872-11923. (SCI)
• K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, J.-L. Han, B. Pal, T.-A. Chao, S.-H. Wu, C.-H. Wong* and C.-Y. Wu*, 2011, “Efficient and Stereoselective Synthesis of alpha(2→9) Oligosialic Acids: From Monomers to Dodecamers”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 9391-9395. (SCI)
• H-L Yen, C-H Liang, C-Y Wu, H Forrest, A Ferguson, KT Choy, J Jones, DDY Wong, PPH Cheung, C-H Hsu, OT Li, KM Yuen, RWY Chan, LLM Poon, MCW Chan, J Nicholls, S Krauss, C-H Wong, Y Guan, RG Webster, RJ Webby & JSM Peiris* , 2011, “Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 14264-14269. (SCI)
• Bin-Ling Tsai, Jeng-Liang Han, Chien-Tai Ren, Chung-Yi Wu* and Chi-Huey Wong*, 2011, “Programmable One-Pot Synthesis of Lewis X dimer and KH-1 epitopes”, TETRAHEDRON LETTERS, 52(17), 2132-2135. (SCI)
• Chen MW, Liao HY, Huang Y, Jan JT, Huang CC, Ren CT, Wu CY, Cheng TJ, Ho DD, Wong CH, 2011, “Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglut”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(9), 3510-3515. (SCI)
• Chung-Yi Wu* and Chi-Huey Wong*, 2011, “Chemistry and Glycobiology”, CHEMICAL COMMUNICATIONS, 47, 6201-6207. (SCI)
• Liang, C.-H., Wang, S.-K., Lin, C.-W., Wong, C.-H.*, Wu, C.-Y.*, 2011, “Effects of neighboring glycans on antibody-carbohydrate interaction”, Angewandte chemie-international edition, 50(7), 1608-1612. (SCI)
• Chung-Yi Wu* and Chi-Huey Wong*, 2011, “Programmable One-Pot Glycosylation”, Topics in Current Chemistry, 301, 223-252. (SCI)
• Y.-L. Huang, C.-Y. Wu*, 2010, “Carbohydrate-Based Vaccines: Challenges and Opportunities”, Expert review of vaccines, 9 (11), 1257-1274. (SCI)
• Chen-I Wu, Yi-Sheng Wang, Nelson G. Chen, Chung-Yi Wu and Chung-Hsuan Chen*, 2010, “Ultrasound Ionization of Biomolecules”, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 24, 2569-2574. (SCI)
• Liang, C.-H.; Wu, C.-Y.*, 2010, “Glycomics: Relevance for Personalized Medicine”, Current Pharmacogenomics and Personalized Medicine, 8, 49-63.
• Hsu, C.-H.; Chu, K.-C.; Lin, Y.-S.; Han, J.-L.; Peng, Y.-S.; Ren, C.-T.; Wu, C.-Y.* and Wong, C.-H.*, 2010, “Highly Alpha-Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides.”, Chemistry-A European Journal, 16(6), 1754-1760. (SCI)
• Liao H-Y, Hsu C-H, Wang S-C, Liang C-H, Ye H-Y, Su C-Y, Jan J-T, Ren C-T, Cheng T.-J R,* Wu C-Y*, Wong C-H*, 2010, “Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays”, Journal of the American Chemical Society, 132, 14849-14856. (SCI)
• Shih-Huang Chang, Jeng-Liang Han, Susan Y. Tseng, Hsin-Yu Lee, Chin-Wei Lin, Yu-Chen Lin, Wen-Yih Jeng, Andrew H.-J. Wang, Chung-Yi Wu,* Chi-Huey Wong*, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides through Phosphonate Chemistry”, Journal of the American Chemical Society, 132, 13371-13380. (SCI)
• Liang C-H, Wu,C-Y*, 2009, “Glycan Array: A Powerful Tool for Glycomics Studies”, Expert Review of Proteomics, 6(6), 631-645. (SCI)
• Wang, C.-C.; Chen, J.-R.; Tseng, Y.-C.; Hsu, C.-H.; Hung, Y.-F.; Chen, S.-W.; Chen, C.-M.; Khoo, K.-H.; Cheng, T.-J.; Cheng, Y.-S.; Jan, J.-T.; Wu, C-Y., Ma, A.C.*; Wong, C-H*, 2009, “Glycans on influenza hemagglutinin affect receptor binding and immune response ”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(43), 18137-18142. (SCI)
• Chi-Hui Linag,Cheng-Chi Wang,Yu-Chen Lin,Chung-Hsuan Chen,Chi-Huey Wong*,Chung-Yi Wu*, 2009, “Iron Oxide/Gold Core/Shell Nanoparticle for Ultrasensitive Detection of Carbohydrate-Protein Interactions”, Analytical Chemistry, 81, 7750-7756. (SCI)
• Chung-Yi Wu*, Pi-Hui Liang*, Chi-Huey Wong*, 2009, “New development of glycan arrays”, ORGANIC & BIOMOLECULAR CHEMISTRY, 7(11), 2247-2254. (SCI)
• Susan Y. Tseng, Cheng-Chi Wang, Chin-Wei Lin, Cheng-Lung Chen, Wen-Yueh Yu, Chung-Hsuan Chen, Chung-Yi Wu*, Chi-Huey Wong*, 2008, “Glycan arrays on aluminum-coated glass slides.”, CHEMISTRY-AN ASIAN JOURNAL, 3(8-9), 1395-1405.. (SCI)
• Pi-Hui Liang, Chung-Yi Wu, William A. Greenberg, Chi-Huey Wong*, 2008, “Glycan arrays: biological and medical applications.”, CURRENT OPINION IN CHEMICAL BIOLOGY, 12(1), 86-92 2008. (SCI)
• Nien-Yeen Hsu, Susan Yu Tseng, Chung-Yi Wu, Chien-Tai Ren, Yuan-Chang Lee, Chi-Huey Wong, Chung-Hsuan Chen*, 2008, “Desorption ionization of biomolecules on metals.”, ANALYTICAL CHEMISTRY, 80(13), 5203-5210. (SCI)
• Cheng-Chi Wang,Yen-Lin Huang, Chien-Tai Ren, Chin-Wei Lin, Jung-Tung Hung, Jyh-Cherng Yu, Alice L. Yu*, Chung-Yi Wu*, Chi-Huey Wong*, 2008, “Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer. ”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(33), 11661-11666. (SCI)
• A. Brik, C.Y. Wu, C. H. Wong*, 2006, “Microtiter Plate Based Chemistry and In Situ Screening: A Useful Approach for Rapid Inhibitors Discovery”, ORGANIC & BIOMOLECULAR CHEMISTRY, 4, 1446-1457. (SCI)
• J.C. Lee, Chung-Yi Wu, J.V. Apon, G. Siuzdak and C.H. Wong, 2006, “Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photocleavable DIOS-MS sugar array”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 45, 2753-2757. (SCI)
• Chung-Yi Wu, K. Y. King, C. J. Kuo, J. M. Fang, Y. T. Wu, M. Y. Ho, C. L. Liao, J. J. Shie, P. H. Liang and C. H. Wong, 2006, “Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Stndrome 3CL Protease”, Chem Biol, 13, 261-268. (SCI)
• C. Y. Wu, A. Brik, S. K. Wang, Y. H. Chen and C. H. Wong, 2005, “Tetrabutylammonium Fluoride-Mediated Rapid Alkylation Reaction in Microtiter Plates for Discovery of Enzyme Inhibitors in Situ”, Chembiochem, 6, 2176-2180. (SCI)
• C. F. Chang, C. W. Ho, Chung-Yi Wu, T. A. Chao, C. H. Wong*, C. H. Lin*, 2004, “Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.”, Chem Biol, 11(9), 1301-1306. (SCI)
• Chung-Yi Wu, J. T. Jan*, S. H. Ma, C. J. Kuo, H. F. Juan, Y. H. E. Cheng, H. H. Hsu, R. H. Liu, J. M. Fang, P. H. Liang and C. H. Wong*, 2004, “Small molecules targeting Severe Acute Respiratory Syndrome (SARS) human coronavirus”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 10012-10017. (SCI)
• Chung-Yi Wu, C. F. Chang, J. S. Y. Chen, C. H. Wong*, C. H. Lin*, 2003, “Rapid Diversity-Oriented Synthesis in Microtiter Plates for in situ Screening: Discovery of Potent and Selective a-Fucosidase Inhibitors”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 42(38), 4661-4664. (SCI)