Assistant Research Specialist

EDUCATION AND POSITIONS HELD:

• Ph.D., Department of Chemistry, Florida State University, 1989-1996
• Postdoctoral Research Fellow, Florida State University, 1996–1999
• Research Associate, Sinon Corporation, 1999-2000
• Postdoctoral Research Fellow, Institute of Biological Chemistry, Academia Sinica, 2000–2006
• Assistant Research Specialist, Genomics Research Center, Academia Sinica, 2006-present

FACILITY MANAGEMENT / EXPERTISE:

My laboratory works are mainly focusing on the synthesis of biologically active oligosaccharides to support GRC glycan array research programs. A long term goal is to establish a representative glycan library with sufficiently structural complexity and diversity to meet the demand. At present, I am maintaining a small but steadily growing collection of carbohydrate antigens to support glycan array development, such as early diagnosis of infectious diseases and cancers. I also collaborate with researchers in the area of carbohydrate-based vaccine development and glycopeptides synthesis.

SELECTED PUBLICATIONS:

• Yen-Lin Huang, Jung-Tung Hung, Sarah K. C. Cheung, Hsin-Yu Lee, Kuo-Ching Chu, Shiou-Ting Li, Yu-Chen Lin, Chien-Tai Ren, Ting-Jen R. Cheng, Tsui-Ling Hsu, Alice L. Yu, Chung-Yi Wu*, and Chi-Huey Wong* , 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110, 2517-2522. (SCI)
• Ting-Jen R. Cheng, Shi-Yun Wang, Wen-Hsien Wen, Ching-Yao Su, Mengi Lin, Wen-I Huang, Ming-Tsan Liu, Ho-Sheng Wu, Nung-Sen Wang, Chung-Kai Cheng, Chun-Lin Chen, Chien-Tai Ren, Chung-Yi Wu, Jim-Min Fang,* Yih-Shyun E. Cheng,* and Chi-Huey Wong*, 2013, “Chemical Probes for Drug-Resistance Assessment by Binding Competition (RABC): Oseltamivir Susceptibility Evaluation”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(1), 366-370. (SCI)
• Chen-Shiou Wu, Chia-Jui Yen, Ruey-Hwang Chou, Shiou-Ting Li, Wei-Chien Huang, Chien-Tai Ren, Chung-Yi Wu*, Yung-Luen Yu*, 2012, “Cancer-Associated Carbohydrate Antigens as Potential Biomarkers for Hepatocellular Carcinoma”, PLoS One, 7, e39466. (SCI)
• Chen, M. W.; Liao, H.-Y.; Huang, Y.; Jan, J.-T.; Huang, C.-C.; Ren, C.-T.; Wu, C.-Y.; Cheng, T.-J.; Ho, D.*; Wong, C.-H.*, 2011, “Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar binding activities of influenza hemagglutinin”, Proceedings of the National Academy of Sciences of the United States of America, 108(9),3510-3515. (SCI)
• Chu, K.-C.; Ren, C.-T.; Liu, C.-P.; Hsu, C.-H.; Sun, T.-H.; Han, J.-L.; Pal, B.; Chao, T.-A.; Lin, Y.-F.; Wu, S.-H.; Wong, C.-H.*; Wu, C.-Y.*, 2011, “Efficient and Stereoselective Synthesis of alpha(2→9) Oligosialic acids: From Monomers to Dodecamers”, Angewandte Chemie International Edition, 50, 9391-9395. (SCI)
• Tsai, B.-L.; Han, J.-L.; Ren, C.-T.; Wu, C.-Y.*; Wong, C.-H., 2011, “Programmable One-Pot Synthesis of Tumor-Associated Carbohydrate Antigens Lewis X dimer and KH-1 epitopes”, Tetrahedron Letters, 52, 2132-2135. (SCI)
• Liao, H.-Y., Hsu, C.-H., Wang, S.-C., Liang C.-H., Ye H.-Y., Su C.-Y., Jan J.-T., Ren C.-T., Cheng T.-J. R.,* Wu, C.-Y.*, Wong C.-H.*, 2010, “Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132, 14849-14856. (SCI)
• Hsu, C.-H.; Chu, K.-C.; Lin, Y.-S.; Han, J.-L.; Peng, Y.-S.; Ren, C.-T.;Wu, C.-Y. and Wong, C.-H., 2010, “Highly Alpha-Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides”, Chemistry-A European Journal, 16(6),1754-1760. (SCI)
• Wang, S. Y.; Su, C. Y.; Lin, M.; Huang, S. Y.; Huang, W. I.; Wang, C. C.; Wu, Y. T.; Cheng, T. J. R.; Yu, H. M.; Ren, C. T.; Wu, C. Y.; Wong, C. H.; Cheng. Y. S. E., 2009, “HA-pseudotyped retroviral vectors for influenza antagonist screening”, JOURNAL OF BIOMOLECULAR SCREENING, 14, 294-302. (SCI)
• Cheng-Chi Wang, Yen-Lin Huang, Chien-Tai Ren, Chin-Wei Lin, Jung-Tung Hung, Jyh-Cherng Yu, Alice L. Yu, Chung-Yi Wu, and Chi-Huey Wong , 2008, “Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer”, Proceedings of the National Academy of Sciences of the United States of America, 105, 11661-11666. (SCI)
• Nien-Yeen Hsu, Susan Yu Tseng, Chung-Yi Wu, Chien-Tai Ren, Yuan-Chang Lee, Chi-Huey Wong and Chung-Hsuan Chen , 2008, “Desorption ionization of biomolecules on metals”, ANALYTICAL CHEMISTRY, 80, 5203-5210. (SCI)
• Lu, C.-P., Ren, C.-T., Wu, S.-H.*, Chu, C.-Y., Lo, L.-C.*, 2007, “Development of an activity-based probe for steroid sulfatases”, CHEMBIOCHEM, 8(18), 2187-2190. (SCI)
• Chien-Tai Ren, Yu-Hsuan Tsai, Yu-Liang Yang, Wei Zou and Shih-Hsiung Wu, 2007, “Synthesis of a Tetrasaccharide Glycosyl Glycerol. Precursor to Glycolipids of Meiothermus taiwanensis ATCC-BAA-400”, J. Org. Chem, 72, 5427-5430. (SCI)
• An-Tai Wu, Yi-Ping Yu, Chien-Tai Ren, Wei Zou and S.-H. Wu, 2005, “9-O-Sulfation on α-NeuAc-(2-8)-NeuAc and inter-residue lactonization”, CARBOHYDRATE RESEARCH, 340, 1219-1223. (SCI)
• Chun-Ping Lu, Chien-Tai Ren, Yi-Ning Lai, S.-H. Wu, Wei-Man Wang, Jean-Yin Chen and Lee-Chiang Lo, 2005, “Design of a Mechanism-Based Probe for Neuraminidase to Capture Influenza Viruses”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 44, 6888-6892. (SCI)
• Hao.-Ping Chen, Fang-Ciao Hsui, Li-Ying Lin, Chien-Tai Ren and S.-H. Wu, 2004, “Coexpression, purification and characterization of the E and S subunits of coenzyme B12 and B6 dependent Clostridium sticklandii D-ornithine aminomutase in Escherichia coli”, EUROPEAN JOURNAL OF BIOCHEMISTRY, 271, 4293-4297.
• C.-T. Ren, C.-S. Chen, Y.-P. Yu, Y.-F. Tsai, P.-Y. Lin, Y.-J. Chen, W. Zou and S.-H. Wu, 2003, “Synthesis of α-(2→5)Neu5Gc Oligomers”, CHEMISTRY-A EUROPEAN JOURNAL, 9, 1085-1095. (SCI)
• C.-T. Ren, C.-S. Chen and S.-H. Wu, 2002, “Synthesis of a Sialic Acid Dimer Derivative 2α-O-Benzyl Neu5Ac-α-(2-5) Neu5Gc”, J. Org. Chem, 67, 1376-1379. (SCI)